DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and dscam

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_031751619.1	Gene:	dscam / 100216449	XenbaseID:	XB-GENE-921689	Length:	2039	Species:	Xenopus tropicalis

Alignment Length:	446	Identity:	96/446 - (21%)
Similarity:	156/446 - (34%)	Gaps:	113/446 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SSFLYVGLGCLIASSVALSTDTG-------------SEGNAGNVGGSTLNNVISEDPEFTDVIEN 60
            |.||....|.|..:.|  ..:.|             .|....|....|:::..:..|...|..|:
Frog   171 SRFLITSTGALYIADV--QNEDGLNNYRCTTRHKYTGETRQSNSARLTVSDPANSAPSIIDGFEH 233

  Fly    61 ITVPAGRNVKLACSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKHRTWFLHIN 125
            ....||..|:|.|........|..|:          .|:|:       :..|...:|....|.|.
Frog   234 HKAMAGERVELPCKASGHPIPKYRWL----------KNNVL-------LEPDSRFQHTVVGLLIE 281

  Fly   126 NVQEEDRGRYMCQINTVTAKTQYG--------FVKVVVPPNIDDALTSSDIIVREGDNVTLRCKA 182
            |.:..|.|.|:|::     ...||        :||..:..||......|.:    |..::|.|..
Frog   282 NTRPSDSGSYVCEV-----WNNYGNAEVIGSLYVKQPLKVNISPRKVKSSV----GSQISLACSV 337

  Fly   183 KGSPEPTIKWKRDDGNKIVINKTLEVHDLETDSLELERISRLHMGAYLC---------------I 232
            .|:.:|.:.|.| :|..|.....:.:..:..::|.::.:::...|||.|               :
Frog   338 TGTDDPDLSWYR-NGEIINAGNNVRITGVNRETLIMDGMAKSDSGAYQCFVRREKMSAQDYVQVV 401

  Fly   233 ASNGVPPSVSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNYWTRENDQMITES 297
            ..:|.|..:|.       ||..|..|        |..::|.|.::..|.....||.::|.:|...
Frog   402 LEDGTPKIISA-------FSEKVVSP--------GEPVSLMCNVKGTPLPTITWTLDDDPIIKNG 451

  Fly   298 SKYKTETIPGH---PSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSPPTTQPPP 359
            :...::.|...   .||     |.|||.|..|.|.|:|.|.|..|.:....::.:..|.:.:|
Frog   452 NHRISQLITSEGNVVSY-----LNITNTQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRP-- 509

  Fly   360 TTTTLRRTTTTAAEIALDGYINTPLNGNGIGIVGEGPTNSVIASGKSSIKYLSNLN 415
                ::..|..|..   |.||:.                .||.....|||:..|.|
Frog   510 ----MKNITAIAGR---DTYIHC----------------RVIGYPYYSIKWYKNSN 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	23/103 (22%)
		Ig	69..139	CDD:143165	16/69 (23%)
		IG_like	165..249	CDD:214653	18/98 (18%)
		IGc2	172..237	CDD:197706	14/79 (18%)
		IG_like	267..348	CDD:214653	23/83 (28%)
		Ig	270..339	CDD:299845	21/71 (30%)
dscam	XP_031751619.1	Ig	26..121	CDD:416386
		Ig strand A'	33..37	CDD:409353
		Ig strand B	40..49	CDD:409353
		Ig strand C	55..61	CDD:409353
		Ig strand C'	63..66	CDD:409353
		Ig strand D	72..75	CDD:409353
		Ig strand E	80..85	CDD:409353
		Ig strand F	98..106	CDD:409353
		Ig strand G	109..121	CDD:409353
		Ig	124..217	CDD:416386	9/47 (19%)
		Ig strand A'	127..136	CDD:409353
		Ig strand B	140..147	CDD:409353
		Ig strand C	157..162	CDD:409353
		Ig strand C'	164..167	CDD:409353
		Ig strand D	172..176	CDD:409353	2/3 (67%)
		Ig strand E	179..185	CDD:409353	2/5 (40%)
		Ig strand F	193..201	CDD:409353	0/7 (0%)
		Ig strand G	205..217	CDD:409353	2/11 (18%)
		Ig strand A	225..228	CDD:409353	1/2 (50%)
		Ig strand A'	234..237	CDD:409353	0/2 (0%)
		IG_like	236..310	CDD:214653	20/95 (21%)
		Ig strand B	242..249	CDD:409353	3/6 (50%)
		Ig strand C	255..260	CDD:409353	2/14 (14%)
		Ig strand C'	262..264	CDD:409353	0/1 (0%)
		Ig strand D	270..274	CDD:409353	0/3 (0%)
		Ig strand E	276..280	CDD:409353	1/3 (33%)
		Ig strand F	289..297	CDD:409353	3/12 (25%)
		Ig strand G	300..310	CDD:409353	1/9 (11%)
		Ig	313..395	CDD:416386	17/86 (20%)
		Ig strand A	314..319	CDD:409353	1/4 (25%)
		Ig strand A'	322..326	CDD:409353	0/3 (0%)
		Ig strand B	329..339	CDD:409353	2/9 (22%)
		Ig strand C	344..350	CDD:409353	2/6 (33%)
		Ig strand C'	351..354	CDD:409353	1/2 (50%)
		Ig strand E	368..374	CDD:409353	1/5 (20%)
		Ig strand F	381..389	CDD:409353	4/7 (57%)
		Ig	406..501	CDD:416386	29/114 (25%)
		Ig strand A	406..409	CDD:409353	1/2 (50%)
		Ig strand A'	415..419	CDD:409353	1/3 (33%)
		Ig strand B	422..431	CDD:409353	2/8 (25%)
		Ig strand C	436..442	CDD:409353	1/5 (20%)
		Ig strand C'	444..447	CDD:409353	1/2 (50%)
		Ig strand D	452..460	CDD:409353	0/7 (0%)
		Ig strand E	464..473	CDD:409353	4/13 (31%)
		Ig strand F	480..488	CDD:409353	4/7 (57%)
		Ig strand G	491..501	CDD:409353	1/9 (11%)
		Ig	504..593	CDD:416386	14/64 (22%)
		Ig strand A	505..507	CDD:409353	0/1 (0%)
		Ig strand A'	512..516	CDD:409353	1/3 (33%)
		Ig strand B	519..526	CDD:409353	3/25 (12%)
		Ig strand C	533..539	CDD:409353	3/5 (60%)
		Ig strand C'	540..542	CDD:409353	1/1 (100%)
		Ig strand D	549..553	CDD:409353
		Ig strand E	557..563	CDD:409353
		Ig strand F	571..579	CDD:409353
		Ig strand G	583..593	CDD:409353
		Ig	596..686	CDD:416386
		Ig strand A	597..599	CDD:409353
		Ig strand A'	604..608	CDD:409353
		Ig strand B	611..620	CDD:409353
		Ig strand C	625..632	CDD:409353
		Ig strand C'	634..636	CDD:409353
		Ig strand D	643..648	CDD:409353
		Ig strand E	651..658	CDD:409353
Ig strand F	665..673	CDD:409353
Ig strand G	676..685	CDD:409353
Ig_DSCAM	689..784	CDD:409397
Ig strand B	707..711	CDD:409397
Ig strand C	720..724	CDD:409397
Ig strand E	749..753	CDD:409397
Ig strand F	763..768	CDD:409397
Ig strand G	777..780	CDD:409397
Ig_DSCAM	785..885	CDD:409398
Ig strand B	805..809	CDD:409398
Ig strand C	818..822	CDD:409398
Ig strand E	849..853	CDD:409398
Ig strand F	863..868	CDD:409398
Ig strand G	876..879	CDD:409398
FN3	886..980	CDD:238020
FN3	987..1084	CDD:238020
FN3	1093..1185	CDD:238020
FN3	1190..1279	CDD:238020
Ig_3	<1303..1364	CDD:404760
Ig strand B	1304..1311	CDD:409353
Ig strand C	1317..1322	CDD:409353
Ig strand C'	1327..1333	CDD:409353
Ig strand D	1337..1341	CDD:409353
Ig strand E	1343..1347	CDD:409353
Ig strand F	1356..1364	CDD:409353
Ig strand G	1367..1377	CDD:409353
FN3	1381..1471	CDD:238020
FN3	1497..1568	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910