DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and mxra5a

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_001919144.3	Gene:	mxra5a / 100151112	ZFINID:	ZDB-GENE-090312-22	Length:	2516	Species:	Danio rerio

Alignment Length:	487	Identity:	111/487 - (22%)
Similarity:	175/487 - (35%)	Gaps:	113/487 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GCLIASSVALSTDTGS-EGNAGNVGGSTLNNVI---------------SEDPEFTDVIENITVPA 65
            |.|...|::| ||.|. |.:..||.|:....:|               ...|:.|||:      .
Zfish  1791 GTLHLHSLSL-TDAGRYECSVTNVIGNARRAIILTVRKSMKYSRAKITFSSPQKTDVV------Y 1848

  Fly    66 GRNVKLACSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKH----RTWFLHINN 126
            |..:.|.|........::.|.               |.:.::...|..:|..    ....|.|.:
Zfish  1849 GGRLHLDCITSGNPEPRIIWR---------------TPSKKLVDAHYSYDSRIKVSANGTLSIIS 1898

  Fly   127 VQEEDRGRYMCQINTVTAKTQYG------FVKVVVPPNIDDALTSSDIIVREGDNVTLRCKAKGS 185
            |.|::.|.|:|     .|:.:.|      .|.::..|...:..|.:|..|..|||:.:.|.|.|.
Zfish  1899 VTEKEDGEYLC-----VARNKIGDDFVPFKVSIMAKPAKIEQKTEADRKVMYGDNLKVDCVASGL 1958

  Fly   186 PEPTIKWKRDDGNKI---------VINKTLEVHDLETDSLELERISRLHMGAYLCIASNGV-PPS 240
            |.|.|:|...||..|         |.::|......:..:|.|..:.....|.|.|.|.|.| ...
Zfish  1959 PNPKIQWALPDGTMINSVIKSERNVGSRTRRYVVFDNGTLLLNEVGMHEEGNYTCYAENQVGKDE 2023

  Fly   241 VSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNYWTRENDQMITESS-KYKTET 304
            ::..:||..|...:|.....::.:..|.:::|:|..:..||.|..|....::.||.|| ||....
Zfish  2024 MNVHVKVVADVPVIVNKTQDVIRVLYGESVSLQCSAKGEPTPLVLWFSPTNRAITSSSDKYFIHN 2088

  Fly   305 IPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGD--MDGNIKLYMSSPPTTQPPPTTTTLR-- 365
                     ...|.|..||..|.|||.|:|:|..|.  ....:::.:|.|.......||.:||
Zfish  2089 ---------NGTLIIKKVQRFDGGNYICLARNSAGQDRKVTRVEILVSPPAINGFKGTTNSLRVS 2144

  Fly   366 ------------RTTTTAAEI-----------------ALDGYINTPLNGNGIGIVGEGPTNSVI 401
                        .|.|.|..:                 .:..|.|..|:...:.:...|....:.
Zfish  2145 SVRDQRKLIDCDATGTPAPRVMWVLPENVVLPAPYYGSRMTVYRNGTLDIRSVRMTDSGQLACIA 2209

  Fly   402 ASGKSSIKYLSNLNE---IDKSKQKLTGSSPK 430
            .:.....|::..|:.   :||.|.|    |||
Zfish  2210 RNEGGETKFIVQLHVTDILDKPKLK----SPK 2237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	17/105 (16%)
		Ig	69..139	CDD:143165	13/73 (18%)
		IG_like	165..249	CDD:214653	27/93 (29%)
		IGc2	172..237	CDD:197706	22/73 (30%)
		IG_like	267..348	CDD:214653	25/83 (30%)
		Ig	270..339	CDD:299845	23/69 (33%)
mxra5a	XP_001919144.3	LRRNT	24..55	CDD:214470
		leucine-rich repeat	35..53	CDD:275380
		LRR_8	52..112	CDD:290566
		leucine-rich repeat	54..77	CDD:275380
		leucine-rich repeat	78..101	CDD:275380
		LRR_8	101..160	CDD:290566
		leucine-rich repeat	102..125	CDD:275380
		LRR_4	125..165	CDD:289563
		leucine-rich repeat	126..149	CDD:275380
		leucine-rich repeat	150..181	CDD:275380
		leucine-rich repeat	182..205	CDD:275380
		LRRCT	214..267	CDD:214507
		IG	478..559	CDD:214652
		Ig	485..545	CDD:143165
		IG	573..657	CDD:214652
		IGc2	581..647	CDD:197706
		I-set	1534..1626	CDD:254352
		Ig	1554..1616	CDD:299845
		I-set	1631..1727	CDD:254352
		Ig	1646..1727	CDD:299845
		IG_like	1740..1825	CDD:214653	12/34 (35%)
		IGc2	1746..1815	CDD:197706	10/24 (42%)
		IG_like	1841..1926	CDD:214653	21/110 (19%)
		IGc2	1849..1916	CDD:197706	15/86 (17%)
		I-set	1932..2030	CDD:254352	26/97 (27%)
		IGc2	1946..2020	CDD:197706	22/73 (30%)
		I-set	2035..2124	CDD:254352	26/97 (27%)
		IGc2	2050..2114	CDD:197706	24/72 (33%)
		Ig	2149..2224	CDD:299845	9/74 (12%)
		IG	2244..2321	CDD:214652
		IGc2	2246..2312	CDD:197706
		IG	2334..2407	CDD:214652
		Ig	2341..2416	CDD:299845
		IG	2429..2515	CDD:214652
		Ig	2439..2512	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I11903
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000