DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and lrfn4b

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_021333806.1	Gene:	lrfn4b / 100149980	ZFINID:	ZDB-GENE-070705-473	Length:	1131	Species:	Danio rerio

Alignment Length:	277	Identity:	49/277 - (17%)
Similarity:	84/277 - (30%)	Gaps:	105/277 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 DRG-----RY---MCQINTVTAKTQYGFVKVVVPPNIDDALTSSDIIVREGDNVTLRCKAKGSP- 186
            |||     |:   .|::...||....||..   ..|......:.|:      ..||||.|..:|
Zfish   839 DRGPQFLSRFWGAFCRLFGTTASLSSGFHP---ESNGQTERVNQDL------ETTLRCMAANNPT 894

  Fly   187 --EPTIKWKRDDGNKIVINKTLEVHDLETDSLELERISRLHMGAYLCIASNGVPPSVSKRIKVSV 249
              ...|.|.....|.:..:.|                              |:.|     .:...
Zfish   895 TWSSYIMWAEYAHNTLKSSAT------------------------------GLSP-----FECQF 924

  Fly   250 DFSPMVWIPHQL-VGIPIGFNITLECFIEANPTSLNYWTRENDQMITESSKYKTETIPGH---PS 310
            .::|.::...:: ||:|...:....|        ...|.|....::..|.:|:.:.....   |:
Zfish   925 GYTPPLFPEKEVQVGVPSAQHFVRRC--------RRTWRRARSALLRTSLRYQHQANRRRRRPPT 981

  Fly   311 YKATMRLTIT------NVQSSD-----YGNYKCVAK-NPRGDMDGNIKLY--------------- 348
            ::...|:.:.      .|:|..     .|.::...| ||     .:.:||
Zfish   982 FRVGQRVWLATKNLPLRVESRKLSQRFIGPFRIARKVNP-----VSYRLYLPRSLRINPTFHVSL 1041

  Fly   349 ----MSSP--PTTQPPP 359
                :|||  |..:|||
Zfish  1042 LKPVLSSPFAPPRRPPP 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	9/31 (29%)
		Ig	69..139	CDD:143165	5/15 (33%)
		IG_like	165..249	CDD:214653	13/86 (15%)
		IGc2	172..237	CDD:197706	10/67 (15%)
		IG_like	267..348	CDD:214653	13/95 (14%)
		Ig	270..339	CDD:299845	13/83 (16%)
lrfn4b	XP_021333806.1	retropepsin_like	58..144	CDD:133136
		RT_LTR	253..429	CDD:238825
		RNase_HI_RT_Ty3	525..646	CDD:260006
		zf-H2C2	716..749	CDD:324145
		rve	772..885	CDD:307008	11/54 (20%)
		Chromo	1069..1116	CDD:306815
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10955
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000