DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and lrit3b

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_009305418.1	Gene:	lrit3b / 100144406	ZFINID:	ZDB-GENE-070424-130	Length:	487	Species:	Danio rerio

Alignment Length:	348	Identity:	64/348 - (18%)
Similarity:	116/348 - (33%)	Gaps:	118/348 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 LTVHNHVITRNPRISVTHDKHDKHRTWFLHINNVQEED--RGRYMCQINTVTA--------KTQY 148
            |.:||:.:.|.|.::|.            ::.||...|  ..|.....|.:||        :||.
Zfish   165 LGLHNNRLARIPLLAVR------------YLRNVTYLDLSSNRLSTLANDLTALWLFSDSNQTQR 217

  Fly   149 GFVKVVVP-PNIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIKWKRDDGNKIVINK------TL 206
            .||..:.. |.:.|...|:.:.:..|            ||.::         :::::      .|
Zfish   218 SFVLGLQDNPWVCDCRLSTLLDISRG------------PESSL---------VLLDRFLTCSEPL 261

  Fly   207 EVHDLETDSLELERISRLHMGAYLCIASNGVPPSVSKRIKVSVDFSPMVWIPHQLVGIPIGFNIT 271
            ::..:...|:||.|..|              |..|:...|::.               .:|..:.
Zfish   262 DLAGVPFQSVELSRCRR--------------PYVVTSATKITA---------------LLGSTVL 297

  Fly   272 LECFIEANPTSLNYWTRENDQMI--------TESSKYKTETIP----GH--PSYKATMR---LTI 319
            |.|....:||....|.:...:.:        |:|| ..||..|    |:  .|.:..:|   :::
Zfish   298 LRCEATGHPTPALMWIKSAKRNLYNQGCCKQTQSS-LDTERFPKKLFGYVQESPRVGVRWSVVSL 361

  Fly   320 TNVQSSDYGNYKCVAKNPRGDMDGNIKLYM---------------------SSPPTTQPPPTTTT 363
            ..:..||.|.|:|.|:|..|..:..:.|.:                     |....|:|...:..
Zfish   362 NGISYSDAGEYRCRAQNMAGISEAVVSLNVVGVMAEYTDFKNSDQQQTTTKSDSKRTKPKQKSKA 426

  Fly   364 LRRTTTTAAEIALDGYINTPLNG 386
            :.....|.:...|...:.||..|
Zfish   427 MMPRNMTGSLSPLKRVLKTPKAG 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	17/70 (24%)
		Ig	69..139	CDD:143165	10/46 (22%)
		IG_like	165..249	CDD:214653	13/89 (15%)
		IGc2	172..237	CDD:197706	9/70 (13%)
		IG_like	267..348	CDD:214653	23/97 (24%)
		Ig	270..339	CDD:299845	21/85 (25%)
lrit3b	XP_009305418.1	LRRNT	51..92	CDD:214470
		leucine-rich repeat	69..89	CDD:275380
		LRR_8	112..172	CDD:290566	3/6 (50%)
		leucine-rich repeat	114..137	CDD:275378
		leucine-rich repeat	138..161	CDD:275378
		LRR_8	160..214	CDD:290566	13/60 (22%)
		LRR_4	160..201	CDD:289563	10/47 (21%)
		leucine-rich repeat	162..185	CDD:275378	6/31 (19%)
		leucine-rich repeat	186..199	CDD:275378	3/12 (25%)
		leucine-rich repeat	215..230	CDD:275378	5/14 (36%)
		Ig	278..391	CDD:299845	28/142 (20%)
		I-set	279..391	CDD:254352	27/127 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900