DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and lsamp

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_031751462.1	Gene:	lsamp / 100124984	XenbaseID:	XB-GENE-5759171	Length:	368	Species:	Xenopus tropicalis

Alignment Length:	348	Identity:	102/348 - (29%)
Similarity:	152/348 - (43%)	Gaps:	47/348 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LYVGLGCLIASSVALSTDTGSEGNAGNVGGSTLNNVISEDPEFTDVIENITVPAGRNVKLACSVK 76
            |.:.|.||:        .||....:|:...||               :||||..|....|.|.|:
Frog    15 LLLRLLCLL--------PTGLPVRSGDFNRST---------------DNITVRQGDTAILRCFVE 56

  Fly    77 NLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKHR--TWFLHINNVQEEDRGRYMCQI 139
            :..| :|||::  :|.|:...:...:.:||:.:     :|..  .:.|.|..|...|.|.|.|.:
Frog    57 DRSS-RVAWLN--RSGIIFAGDDKWSLDPRVEL-----EKRSLLEYSLRIQKVDVSDEGPYTCSV 113

  Fly   140 NTVT-AKTQYGFVKVVVPPNIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIKWKRDDGNKIVIN 203
            .|.. .||...::.|.|||.|.:  .|:||.|.||.||||.|.|.|.|||.|.|:    :.....
Frog   114 QTKQHTKTTQVYLIVQVPPKISN--ISADITVNEGSNVTLMCIAYGRPEPMITWR----HLTPTA 172

  Fly   204 KTLEVHDLETDS--LELERISRLHMGAYLCIASNGVPPSVSKRIKVSVDFSPMVWIPHQLVGIPI 266
            .|....|.|.:.  ||::.|:|...|.|.|.|:|.|..:..|:::|:|::.|:: ...:......
Frog   173 GTSPARDFEGEEEFLEIQGITREQSGRYECKAANEVASADVKQVRVTVNYPPII-TESKSNEATT 236

  Fly   267 GFNITLECFIEANPTSLNYWTRENDQMITESSKYKTETIPGHPSYKATMRLTITNVQSSDYGNYK 331
            |....|.|...|.|.....|.:::.:....:|....| |....|....|   :.||....||||.
Frog   237 GKQAILRCEASAVPAPDFEWYKDDTRSRRINSAQGLE-IRNTGSRSVLM---VANVTEEHYGNYT 297

  Fly   332 CVAKNPRGDMDGNIKLYMSSPPT 354
            |||.|..|..:.::.||....||
Frog   298 CVAANKLGITNTSLYLYKRVSPT 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	28/98 (29%)
		Ig	69..139	CDD:143165	19/71 (27%)
		IG_like	165..249	CDD:214653	33/85 (39%)
		IGc2	172..237	CDD:197706	26/66 (39%)
		IG_like	267..348	CDD:214653	22/80 (28%)
		Ig	270..339	CDD:299845	20/68 (29%)
lsamp	XP_031751462.1	Ig	38..128	CDD:416386	28/112 (25%)
		FR1	38..54	CDD:409353	7/30 (23%)
		Ig strand A'	39..45	CDD:409353	4/5 (80%)
		Ig strand B	47..55	CDD:409353	2/7 (29%)
		CDR1	55..59	CDD:409353	1/3 (33%)
		FR2	60..67	CDD:409353	4/9 (44%)
		Ig strand C	60..66	CDD:409353	4/6 (67%)
		CDR2	68..78	CDD:409353	2/9 (22%)
		Ig strand C'	70..73	CDD:409353	1/2 (50%)
		Ig strand C'	75..78	CDD:409353	0/2 (0%)
		FR3	79..114	CDD:409353	10/39 (26%)
		Ig strand D	83..90	CDD:409353	2/11 (18%)
		Ig strand E	93..99	CDD:409353	1/5 (20%)
		Ig strand F	106..114	CDD:409353	3/7 (43%)
		CDR3	115..119	CDD:409353	1/3 (33%)
		Ig strand G	119..128	CDD:409353	2/8 (25%)
		FR4	121..128	CDD:409353	1/6 (17%)
		Ig_3	131..206	CDD:404760	32/80 (40%)
		Ig strand A'	138..143	CDD:409353	3/4 (75%)
		Ig strand B	149..156	CDD:409353	4/6 (67%)
		Ig strand C	162..167	CDD:409353	2/8 (25%)
		Ig strand C'	173..175	CDD:409353	0/1 (0%)
		Ig strand E	185..191	CDD:409353	2/5 (40%)
		Ig strand F	198..205	CDD:409353	3/6 (50%)
		Ig strand G	212..220	CDD:409353	2/7 (29%)
		Ig_3	223..302	CDD:404760	21/83 (25%)
		putative Ig strand A	224..230	CDD:409353	1/6 (17%)
		Ig strand B	240..244	CDD:409353	1/3 (33%)
		Ig strand C	253..257	CDD:409353	0/3 (0%)
		Ig strand E	281..285	CDD:409353	1/6 (17%)
		Ig strand F	295..300	CDD:409353	3/4 (75%)
		Ig strand G	308..311	CDD:409353	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10578
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I4412
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060