DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nsun5 and NSUN7

DIOPT Version :9

Sequence 1:	NP_650787.1	Gene:	Nsun5 / 7354421	FlyBaseID:	FBgn0259704	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_078953.4	Gene:	NSUN7 / 79730	HGNCID:	25857	Length:	718	Species:	Homo sapiens

Alignment Length:	492	Identity:	107/492 - (21%)
Similarity:	180/492 - (36%)	Gaps:	146/492 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RATAKILKAALEQQKCIKTLI-------------------------FAEKHARTRSLHTVLKKFS 54
            |.:.::..:||:.|..::|::                         |.::..:||.|       |
Human    88 RLSYELAFSALKYQDILETILIDSCIFPSTTIPDHLSSLIIVMLYDFQDRKFQTRVL-------S 145

  Fly    55 ENRVALEKAIEETGLLRDNPSFDPSLAKILVTELLFGRKELNGESKPV-----QTVRSYKDRLLN 114
            :|...:.:..|...||.   ||...||..|      .|..:..::..:     :|||  |..|
Human   146 DNEEPISEVQEVENLLN---SFKIKLAAAL------ARCRIKHDALSIYHILPETVR--KQEL-- 197

  Fly   115 SIRDFGVQRKEPNPRYVRINTNLYSLAEALDYLHKSDWRRKELPADASYADFLTAIKSLAENEFM 179
                    |....|.|..|||...|..|..:.|.:..:.:            :.::..:.:..|.
Human   198 --------RASTLPLYAWINTCKISPEEVYNNLKRRGYNK------------VKSVLHIDDKVFA 242

  Fly   180 TDLHVEGVLIFPAKWSNYWVRHPLVHSKRFILQNKATCLAA-----------ELLAPPSGA--TV 231
            .|.|...|||||:...|..:...|....:.|.|:|:..||.           ::|...:|:  ||
Human   243 VDQHCYDVLIFPSHLKNDLINIDLFKDYKLIFQDKSRSLAVHSVKALLNMDDDVLMVNTGSWYTV 307

  Fly   232 LDMCAAPGMKT--VHICNVMQNKGCIYSVEQDHVRYNTLCEITKDAGCDIVKPILGDALNLTPE- 293
            ..|.......|  |.:|.|           |...:...|..:....||..::.:....:|:..:
Human   308 SHMSILTNNNTSKVFVCGV-----------QSQAKDPDLKTLFTKIGCKNIEILHEKFINIESKD 361

  Fly   294 -RFPDVEYILVDPSCSGSGMQNRMTVCDEPKED--------------KRLQKLQGLQIKILSHAM 343
             |...|:.||:.|.|||.|:.|.:.......||              .:|..|...|.:.|:|||
Human   362 HRLQKVKVILLLPRCSGLGVSNPVEFILNEHEDTEFLKDHSQGGISVDKLHVLAQQQYEQLTHAM 426

  Fly   344 GAFPNVKRIAYCTCSLWKEENEQVVQRCLQLNPSFKLLSCKKALRNKWHNVGDKDYP-------- 400
             .|...:.:.|||||::.||||.||               ||||  ::.::|:|..|
Human   427 -KFTKAQAVVYCTCSVFPEENEAVV---------------KKAL--EFQDLGNKGQPYRLSPPVL 473

  Fly   401 --------NIGKNVLYCQPDSDLTDGIFLALFEKRRE 429
                    .:..:..:....|::|:|.||::..:.|:
Human   474 PLCSLKEIQLSTDKFFRMEPSEITNGCFLSILTRERD 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsun5	NP_650787.1	RsmB	<124..428	CDD:223222	80/350 (23%)
NSUN7	NP_078953.4	Methyltr_RsmF_N	131..509	CDD:330305	101/446 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..557
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	578..616
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..718
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0144
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1128973at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.780