DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsun5 and NSUN5

DIOPT Version :9

Sequence 1:	NP_650787.1	Gene:	Nsun5 / 7354421	FlyBaseID:	FBgn0259704	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_001161819.1	Gene:	NSUN5 / 55695	HGNCID:	16385	Length:	470	Species:	Homo sapiens

Alignment Length:	440	Identity:	145/440 - (32%)
Similarity:	223/440 - (50%)	Gaps:	46/440 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 YRATAKILKAALEQQKCIKTLIFAEKHARTRSLHTVLKKFSENRVALEKAIEETGLLRDNPSFDP 78
            |.|.|.:|.....:|..||.|:::......:.|:.::.:.......|:..|...||||......|
Human     4 YAAAAGVLAGVESRQGSIKGLVYSSNFQNVKQLYALVCETQRYSAVLDAVIASAGLLRAEKKLRP 68

  Fly    79 SLAKILVTELLFGRKELNGESKPVQTVRSYKDRLLNSIRDF----GVQRKE--------PN---- 127
            .|||:||.|||.|:....|..:....:..::.||...:...    ||.|.|        |.
Human    69 HLAKVLVYELLLGKGFRGGGGRWKALLGRHQARLKAELARLKVHRGVSRNEDLLEVGSRPGPASQ 133

  Fly   128 -PRYVRINTNLYSLAEALDYLHKSDWRRKELPADASYADFLTAIKSLAENEFMTDLHVEGVLIFP 191
             ||:||:||......:.:||..:..:   .....||..|.|.|:|.   ..|:.|..:..:|:||
Human   134 LPRFVRVNTLKTCSDDVVDYFKRQGF---SYQGRASSLDDLRALKG---KHFLLDPLMPELLVFP 192

  Fly   192 AKWSNYWVRHPLVHSKRFILQNKATCLAAELLAPPSGATVLDMCAAPGMKTVHICNVMQNKGCIY 256
            |:...:  .|||..:...|||::|:||.|.||.||.|:.|:|.|||||.||.|:..:::|:|.|:
Human   193 AQTDLH--EHPLYRAGHLILQDRASCLPAMLLDPPPGSHVIDACAAPGNKTSHLAALLKNQGKIF 255

  Fly   257 SVEQDHVRYNTLCEITKDAG---CDIVKPILGDALNLTPE--RFPDVEYILVDPSCSGSGMQNRM 316
            :.:.|..|..::..:...||   |::.:.   |.|.::|.  |:.:|.|||:|||||||||.:|.
Human   256 AFDLDAKRLASMATLLARAGVSCCELAEE---DFLAVSPSDPRYHEVHYILLDPSCSGSGMPSRQ 317

  Fly   317 TVCDEP----KEDKRLQKLQGLQIKILSHAMGAFPNVKRIAYCTCSLWKEENEQVVQRCLQLNP- 376
              .:||    ....||..|.|.|.:.|.||: .||:::|:.|.||||.:||||.||:..||.||
Human   318 --LEEPGAGTPSPVRLHALAGFQQRALCHAL-TFPSLQRLVYSTCSLCQEENEDVVRDALQQNPG 379

  Fly   377 SFKLLSCKKALRNKWHNVGDKDYPNIGKNVLYCQPDSDLTDGIFLALFEK 426
            :|:|.....|    |.:.|...:|. .::.|...|::.|:.|.|:|:.|:
Human   380 AFRLAPALPA----WPHRGLSTFPG-AEHCLRASPETTLSSGFFVAVIER 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsun5	NP_650787.1	RsmB	<124..428	CDD:223222	114/326 (35%)
NSUN5	NP_001161819.1	RsmB	95..425	CDD:223222	119/349 (34%)
		AdoMet_MTases	219..420	CDD:302624	81/211 (38%)
		S-adenosyl-L-methionine binding	234..240		5/5 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155321
Domainoid	1	1.000	128	1.000	Domainoid score	I5310
eggNOG	1	0.900	-	-		E1_COG0144
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	199	1.000	Inparanoid score	I3795
Isobase	1	0.950	-	0	Normalized mean entropy	S2551
OMA	1	1.010	-	-		QHG53910
OrthoDB	1	1.010	-	-		D1128973at2759
OrthoFinder	1	1.000	-	-		FOG0003757
OrthoInspector	1	1.000	-	-		otm40273
orthoMCL	1	0.900	-	-		OOG6_102591
Panther	1	1.100	-	-	LDO	PTHR22807
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1816
SonicParanoid	1	1.000	-	-		X3119
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750