DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsun5 and nsun2

DIOPT Version :9

Sequence 1:	NP_650787.1	Gene:	Nsun5 / 7354421	FlyBaseID:	FBgn0259704	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_001015962.1	Gene:	nsun2 / 548716	XenbaseID:	XB-GENE-962623	Length:	798	Species:	Xenopus tropicalis

Alignment Length:	470	Identity:	101/470 - (21%)
Similarity:	164/470 - (34%)	Gaps:	127/470 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 EKHARTRSLHTVLKKFSENRVALEKAIEETG---LLRDNPSFDPSLAKILVTELLFGRKELNGES 99
            ::|.|:....:..:: .:.|.|.|:|..|.|   ::::|..|:....::.:..        :||
Frog    10 QRHQRSTEQRSPAEE-EQRRKAREQAAWECGYPEIIKENKLFEHYYQELKIVP--------DGE- 64

  Fly   100 KPVQTVRSYKDRLLNSIRDFGVQRKEPNPRYVRINTNLYSLAEALDYLH-------------KSD 151
                     .|:.:.|:|       ||.|..:||..  |. :.|.:.||             :.|
Frog    65 ---------WDKFMASLR-------EPLPATIRITG--YK-SHAKEILHCLKEKYFKELQDIEVD 110

  Fly   152 WRRKELPADAS-YADFLTAIKSLAENEFMTDLHVEGVLIFPAKWSNYWVRHPLVHSKRFILQNKA 215
            .::.|.|...| |.:.|....:|:.........:|       |:..:.|..  ..|.....|...
Frog   111 GQKIEAPQPLSWYPEELAWHTNLSRKIIRKSPELE-------KFHQFLVNE--TESGNISRQEAV 166

  Fly   216 TCLAAELLAPPSGATVLDMCAAPGMKTVH------------------ICNVMQNKGCIYSVEQDH 262
            :.:...||.......:||||||||.||..                  |.|.:.||.|...|.|..
Frog   167 SMIPPVLLKVQPHHKILDMCAAPGSKTAQIIEMLHADMNVPFPEGFVIANDVDNKRCYLLVHQAK 231

  Fly   263 VRYNTLCEITKDAGCDIVKPIL----GDALNLTPERFPDVEYILVDPSCSGSGMQNRMTVCDEPK 323
             |.|:.|.:..:.....:..:|    |....|..:|      ||.|..|||.|...:.  .|..|
Frog   232 -RLNSPCIMVVNHDASSIPRLLVENNGSREVLYYDR------ILCDVPCSGDGTLRKN--IDVWK 287

  Fly   324 EDKRLQKLQ--GLQIKILSHAMGAFPNVKRIAYCTCSLWKEENEQVVQRCLQLN----------- 375
            :...|..||  ||||:|.:..:.......|:.|.||||...|:|.|:...|..:
Frog   288 KWTTLNSLQLHGLQIRIATRGVEQLAEGGRMVYSTCSLNPVEDEAVIASLLDKSEGSLELADVAS 352

  Fly   376 -----------PSFKLLSCKKALRNKWHNVGDKDYPNI--------------GKNVLYCQ---PD 412
                       ..:|:::.:.....||.::....:..|              ..|:..|.   |.
Frog   353 EIPGLKWMPGITQWKVMTKEGHWYEKWEDIPTSRHTQIRPTMFPPKDEEKLKSMNLNRCMRILPH 417

  Fly   413 SDLTDGIFLALFEKR 427
            ...|.|.|:|:..|:
Frog   418 HQNTGGFFVAVLIKK 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsun5	NP_650787.1	RsmB	<124..428	CDD:223222	86/381 (23%)
nsun2	NP_001015962.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		3/20 (15%)
		RsmB	19..432	CDD:223222	98/459 (21%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01023	186..192		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..499
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	723..798
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910