DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsun5 and Nsun2

DIOPT Version :9

Sequence 1:	NP_650787.1	Gene:	Nsun5 / 7354421	FlyBaseID:	FBgn0259704	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_663329.3	Gene:	Nsun2 / 28114	MGIID:	107252	Length:	757	Species:	Mus musculus

Alignment Length:	399	Identity:	86/399 - (21%)
Similarity:	136/399 - (34%)	Gaps:	106/399 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 PRYVRINTNLYSLAEALDYLHKSDW------RRKELPAD---ASYADFLTAIKSLAENEF---MT 180
            |..|:.|.......:.|..:.:.:|      .|:.|||.   ..|......|....:|::   :.
Mouse    39 PEIVKENKLFEHYYQELKIVPEGEWDQFMESLREPLPATLRITGYKSHAKEILHCLKNKYFKELE 103

  Fly   181 DLHVEGVLI--------FP--------------------AKWSNYWVRHPLVHSKRFILQNKATC 217
            ||.|:|..:        :|                    ||:..:.|..  ..|.....|...:.
Mouse   104 DLEVDGQKVEVPQPLSWYPEELAWHTNLSRKILRKSPLLAKFHQFLVSE--TESGNISRQEAVSM 166

  Fly   218 LAAELLAPPSGATVLDMCAAPGMKTVHICNVMQ-------NKGCIYSVEQDHVRYNTLCEITKDA 275
            :...||.......:||||||||.||..:..::.       .:|.:.:.:.|:.|...|....|..
Mouse   167 IPPLLLNVEPHHKILDMCAAPGSKTTQLIEMLHADMSVPFPEGFVIANDVDNKRCYLLVHQAKRL 231

  Fly   276 GCDIVKPILGDALNLTPERFPDV---------EYILVDPSCSGSG-MQNRMTVCDEPKEDKRLQK 330
            ....:..:..||.:: |....||         :.||.|..|||.| |:..:.|..:......||
Mouse   232 SSPCIMVVNHDASSI-PRLTVDVDGRKEILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQ- 294

  Fly   331 LQGLQIKILSHAMGAFPNVKRIAYCTCSLWKEENEQVVQRCLQLN-------------PSFKLL- 381
            |.|||::|.:..........|:.|.||||...|:|.|:...|:.:             |..|.:
Mouse   295 LHGLQLRIATRGAEQLAEGGRMVYSTCSLNPVEDEAVIAALLEKSEGALELADVSAELPGLKWMP 359

  Fly   382 ---SCKKALRN-----KWHNVGDKDYPNIGKNVLYCQPDSDL--------------------TDG 418
               ..|...|:     .||.|....:..|...:.   |.:||                    |.|
Mouse   360 GVSQWKVMTRDGQWFADWHEVPQGRHTQIRPTMF---PPTDLEKLQAMHLERCLRILPHHQNTGG 421

  Fly   419 IFLALFEKR 427
            .|:|:..|:
Mouse   422 FFVAVLVKK 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsun5	NP_650787.1	RsmB	<124..428	CDD:223222	86/399 (22%)
Nsun2	NP_663329.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		RsmB	28..430	CDD:223222	85/397 (21%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01023	184..190		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..504
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	716..757
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0144
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810