DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsun5 and NSUN6

DIOPT Version :9

Sequence 1:	NP_650787.1	Gene:	Nsun5 / 7354421	FlyBaseID:	FBgn0259704	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	XP_011517685.1	Gene:	NSUN6 / 221078	HGNCID:	23529	Length:	472	Species:	Homo sapiens

Alignment Length:	256	Identity:	71/256 - (27%)
Similarity:	109/256 - (42%)	Gaps:	65/256 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 LQNKATCLAAELLAPPSGATVLDMCAAPGMKTVHICNVMQNKGCIYSVEQ-----DHVRYNTL-- 268
            |||..:.|.:.:|.|..|..:||:|||||.||.||..:|.::|.:.::::     :.::.|.|
Human   221 LQNLPSALVSHVLNPQPGEKILDLCAAPGGKTTHIAALMHDQGEVIALDKIFNKVEKIKQNALLL 285

  Fly   269 --------C-EITKDAGCDIVKPILGDALNLTPERFPDVEYILVDPSCSGSGMQNRMTVCDEPKE 324
                    | :.||....|:|:...|:...| ||.|   :.||:|..|||.|.:..|......||
Human   286 GLNSIRAFCFDGTKAVKLDMVEDTEGEPPFL-PESF---DRILLDAPCSGMGQRPNMACTWSVKE 346

  Fly   325 DKRLQKLQGLQIKILSHAMGAFPNVKRIAYCTCSLWKEENEQVVQ------RCLQLNPSFKLLSC 383
               :...|.||.|:.:.|:........:.|.||::...|||:.|.      .||||.|
Human   347 ---VASYQPLQRKLFTAAVQLLKPEGVLVYSTCTITLAENEEQVAWALTKFPCLQLQP------- 401

  Fly   384 KKALRNKWHNVGDKDYPNIGKNVLYCQ---------------PDSDLTDGIFLALFEKRRE 429
                  :...:|.:.....|   |.|:               ||:|:.     :|.|.|||
Human   402 ------QEPQIGGEGMRGAG---LSCEQLKQLQRFDPSAVPLPDTDMD-----SLREARRE 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsun5	NP_650787.1	RsmB	<124..428	CDD:223222	68/253 (27%)
NSUN6	XP_011517685.1	PUA	114..205	CDD:214635
NSUN6	XP_011517685.1	RsmB	<218..468	CDD:223222	71/256 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0144
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810