DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7f and Grid2

DIOPT Version :9

Sequence 1:	NP_001138177.1	Gene:	Ir7f / 7354418	FlyBaseID:	FBgn0259188	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_077355.2	Gene:	Grid2 / 79220	RGDID:	68368	Length:	1007	Species:	Rattus norvegicus

Alignment Length:	754	Identity:	149/754 - (19%)
Similarity:	259/754 - (34%)	Gaps:	252/754 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SGYSI--YKSYLENSRIDMQGEDANLYVARALRLVIENVLAQLSTTLVVTISTRHL--------- 70
            |.|.|  .:.:|:  ::..||.|..|.       .:||.:.::.|||..|:....|
  Rat   174 SEYDIRGIQEFLD--KVSQQGMDVALQ-------KVENNINKMITTLFDTMRIEELNRYRDTLRR 229

  Fly    71 -------GTA-----------------HWFEYMMNILMDSWRMVAVQLLRIRPDL----VVN--- 104
                   .||                 ||.     |:.:....|.||.| :|..:    ::.
  Rat   230 AILVMNPATAKSFISEVVETNLVAFDCHWI-----IINEEINDVDVQEL-VRRSIGRLTIIRQTF 288

  Fly   105 PVP---------GRKRVSLLMVDSYQGLLDTNITASNANFDDPDYYFIFLQARDHLIPKELQLIL 160
            |||         |..|:|..:.|....... |:..||...    |..:.|.|  :...|:|:...
  Rat   289 PVPQNISQRCFRGNHRISSTLCDPKDPFAQ-NMEISNLYI----YDTVLLLA--NAFHKKLEDRK 346

  Fly   161 DHCLAHF---------WLHCNVMIQT-----------------------AQVEVLVYTYYPYTAD 193
            .|.:|..         |.....|::|                       ...|:|...|......
  Rat   347 WHSMASLSCIRKNSKPWQGGRSMLETIKKGGVNGLTGDLEFGENGGNPNVHFEILGTNYGEELGR 411

  Fly   194 ACQK-AYPIPVNTFDGRKWKASQMFPDKL-SQMHGCPLTVLTWHQPPFV----ELVWDPKHNRSR 252
            ..:| ....||...:|      .:...|| :.|.|..|.|:|..:.|||    .::..||    :
  Rat   412 GVRKLGCWNPVTGLNG------SLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPK----K 466

  Fly   253 GSGFEIQLVEHLARRMNFSLELVNIALLRPNAYRLAEGSSEGPIEKLLQRNVNISMGYFRKTARR 317
            ..||.|.:::.|:..:.|:.| :.:|..........:|:..|.:.:|:.:..:|.:.....|..|
  Rat   467 YQGFSIDVLDALSNYLGFNYE-IYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDR 530

  Fly   318 NQLLTTPMSYYSANLVAVLQLERYRIGSLALLVFPFELSVW-----MLLLLALLIHL--GIHLPS 375
            ..::.....|...::..:|:.....:...|.|. ||:||:|     .:||:.||::|  .::.|.
  Rat   531 ENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLA-PFDLSLWACIAGTVLLVGLLVYLLNWLNPPR 594

  Fly   376 ARRGNEE----------------DGGGGLQVVAL----LLGAALARLPRSWRHRFIAAHWLWASI 420
            .:.|:..                ..||.:....|    ::||        |        ||:|.|
  Rat   595 LQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGA--------W--------WLFALI 643

  Fly   421 PL--------------RI--SYQSL------------------LFHLIRLQLYNTPSFSLDQLLA 451
            .:              ||  |.|||                  ::..:|::..|  .|..|.:.:
  Rat   644 VISSYTANLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLN--PFERDSMYS 706

  Fly   452 EGFQGICTAN-TQRLLLEMPQLARDPDSIQSV---DTPFDWD--VLNVLTRNRNRKIF-----AV 505
            :.::.|..:| ::..:||      ....||.|   :..|.||  ||..:..|.....|     .|
  Rat   707 QMWRMINRSNGSENNVLE------SQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTVGNTV 765

  Fly   506 ANQDVTLSFLHSSAHPNAFHVVKQPVNVEYAG-MYMPKHSF--------LYEKMDD-------DI 554
            |::...::..|.|.:.:.|.  ::.:.::.:| |.:.||.:        ||..:|.       ||
  Rat   766 ADRGYGIALQHGSPYRDVFS--QRILELQQSGDMDILKHKWWPKNGQCDLYSSVDAKQKGGALDI 828

  Fly   555 RRLD------ASGFIHA---------WRRASFASVHRKE 578
            :.|.      |:|.:.:         |.|...:.|..||
  Rat   829 KSLAGVFCILAAGIVLSCLIAVLETWWSRRKGSRVPSKE 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7f	NP_001138177.1	Periplasmic_Binding_Protein_Type_2	231..>358	CDD:304360	28/130 (22%)
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		40/192 (21%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:415822	52/282 (18%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	81/397 (20%)
		Interaction with AP4M1. /evidence=ECO:0000269\|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810