DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7f and Nmdar1

DIOPT Version :9

Sequence 1:	NP_001138177.1	Gene:	Ir7f / 7354418	FlyBaseID:	FBgn0259188	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster

Alignment Length:	730	Identity:	131/730 - (17%)
Similarity:	236/730 - (32%)	Gaps:	240/730 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KSYLENSRIDMQGEDANLYVARA----------------------LRLVIENVLAQLST---TLV 62
            :|:.|: .|||:...:.:|:..|                      :.:|.|..|...:|   .|.
  Fly   221 ESFTEH-LIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFSNNTPDGVLG 284

  Fly    63 VTISTRHLGTAHWFEYMMNILMDSWRMVAVQLLRIRP----DLVVNPVPGRKRVSLLMVDSYQGL 123
            :.:...|....|..:.:..:......|::.:.:...|    |..||...|::        .:|.|
  Fly   285 LQLEHAHSDKGHIRDSVYVLASAIKEMISNETIAEAPKDCGDSAVNWESGKR--------LFQYL 341

  Fly   124 LDTNITASNAN--FDDP--------DYYFIFLQARDHLIPKELQLILDHCLAHFWLHCNVMIQTA 178
            ...|||.....  |||.        |...|..|.:.|::.|         .::..:...:.::..
  Fly   342 KSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHVVGK---------FSYDSMRAKMRMRIN 397

  Fly   179 QVEVLVYTYYPYTADACQKAYPIPVNTFDGRKWKASQ-------MFPDKLSQMHGCPLTVLTWHQ 236
            ..|::                           |...|       |.|..        |.:||..:
  Fly   398 DSEII---------------------------WPGKQRRKPEGIMIPTH--------LRLLTIEE 427

  Fly   237 PPFVEL--VWD------------PKHNRSRGS-------GFEIQLVEHLARRMNFSLELVNIALL 280
            .|||.:  :.|            |..|.|..:       |:.|.|:..|::|:||:.:|.    |
  Fly   428 KPFVYVRRMGDDEFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLA----L 488

  Fly   281 RPNA----YRLAEGSS--------EGPIEKLLQRNVNISMGYFRKTARRNQLL--TTPMSYYSAN 331
            .|:.    |.|...:.        .|.|.:|:....::.:........|.:.:  :.|..|..
  Fly   489 SPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQG-- 551

  Fly   332 LVAVLQLERYRIGSLALLVFPFELSVWMLLL-----LALLIHL-------GIHLPSARRGNEEDG 384
             :.:|:.:..|..:|...:.||..::|:|::     :||:::|       |....|....|||..
  Fly   552 -ITILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKA 615

  Fly   385 GGGLQVV----ALLLGAALAR-LPRSWRHRFIAAHWLWASIPLRISYQSLLFHLIRLQLYNTPSF 444
            ......|    .:||.:.:.. .|||:..|.:...|...::.:..||.:.|...:.|:...|.
  Fly   616 LNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTK-- 678

  Fly   445 SLDQLLAEGFQGICTANTQRLLLEMPQLARDPDSIQSVDTPFDWDVLNVLTRNRNRKIFAVANQD 509
                     ..||   |..||...|..|........|||..|                    .:.
  Fly   679 ---------LSGI---NDARLRNTMENLTCATVKGSSVDMYF--------------------RRQ 711

  Fly   510 VTLSFLHSSAHPNAFHVVKQPVNVEYAGMYMPKHSFLYEKMDDDIRRLD---------------- 558
            |.||.::.:...|.:...:|.:.....|..|   :|::     |..||:
  Fly   712 VELSNMYRTMEANNYATAEQAIQDVKKGKLM---AFIW-----DSSRLEYEASKDCELVTAGELF 768

  Fly   559 -ASGFIHAWRRAS---------FASVHRKEQVHMTSRRYINHAKLS-------------GIYMVM 600
             .||:....::.|         ....|....:....:::|.|..:.             |: ..|
  Fly   769 GRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEKTPNTLGL-KNM 832

  Fly   601 AGLYLLAGLLFAGEV 615
            ||:::|.|:..||.|
  Fly   833 AGVFILVGVGIAGGV 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7f	NP_001138177.1	Periplasmic_Binding_Protein_Type_2	231..>358	CDD:304360	32/161 (20%)
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	35/228 (15%)
		ANF_receptor	58..371	CDD:279440	29/158 (18%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	85/457 (19%)
		HisJ	451..>558	CDD:223904	22/113 (19%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	27/137 (20%)
		Lig_chan	575..838	CDD:278489	55/305 (18%)
		CaM_bdg_C0	854..882	CDD:287524
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439105
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840