DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7f and GluRIIB

DIOPT Version :9

Sequence 1:	NP_001138177.1	Gene:	Ir7f / 7354418	FlyBaseID:	FBgn0259188	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster

Alignment Length:	591	Identity:	116/591 - (19%)
Similarity:	192/591 - (32%)	Gaps:	163/591 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 VAVQLLRIRP----------DLVVNPVPGR--KRVSLLMVDS----YQGLLDTNITASNANFDDP 138
            |||..:|||.          |:..|.|..|  ...|.|:.||    |..||:.:        ..|
  Fly   262 VAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNALLEIS--------QRP 318

  Fly   139 DYYFI-------FLQARDHLI-------PK---------ELQL----------------ILDHCL 164
            .:|..       |.|....|:       ||         .||:                |:|. :
  Fly   319 GFYIPNFSCGRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNLEVYNPIIDR-V 382

  Fly   165 AHFWLHCNVMIQTAQVEVLVYTYYPYTADACQKAYPIPVNTFDGRKWKASQMFPDKLSQMHGCPL 229
            .|.|   |...|....|.|                  ..|:....|.|..|...| .||.   |:
  Fly   383 THIW---NKEFQLVDFEKL------------------RENSTQALKQKRLQNKED-FSQK---PI 422

  Fly   230 --TVLTWHQPPFVELVWDPK----HNRSRGSGFEIQLVEHLARRMNFSLELVNIALLRPNAYRLA 288
              ||.|....|:.....:|:    ....|..|:.:.|:..||:...|..   |...:|.|.|...
  Fly   423 RYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDF---NFEPVRDNKYGSY 484

  Fly   289 EGSS---EGPIEKLLQRNVNISMGYFRKTARRNQLLTTPMSYYSANLVAVLQLERYRIGSLALLV 350
            :.::   :|.|.:|:..|..|.:.....|..|..::...:.:....:..:...|......:...:
  Fly   485 DANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFL 549

  Fly   351 FPFELSVWMLLLLALLIHLGIHLPSAR--------------RGNEEDGGGGL-QVVALLLGAALA 400
            .|:...||:.:::|::|.....:.:.|              |..|......| ..:.|:||:.|.
  Fly   550 NPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREMERQNIWHLSNALWLVLGSMLN 614

  Fly   401 R----LPRSWRHRFIAAHWLWASIPLRISYQSLLFHLIRLQLYNTPS------FSLDQLLAEG-- 453
            :    |||....|.:.|.| |. ..|.||..    ::.:|..:.|.|      .||..|:.:.
  Fly   615 QGCDLLPRGLPMRLLTAFW-WI-FALLISQT----YIAKLAAFITSSKIAGDIGSLHDLVDQNKV 673

  Fly   454 ----FQGICTA-------NTQRLLLEMPQLARDPDSIQSVDTPFDWDVLNVLTRNRNRKIFAVAN 507
                .:|..|:       :|...:.....|:..||:               .|:|....:..|..
  Fly   674 QFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDA---------------FTKNNEEGVDRVKL 723

  Fly   508 QDVTLSFLHSSAHPNAFHVVKQPVNVEYAG-MYMPKHSFLYEKMDDDIRRLDASGFIHAWRRASF 571
            ...|.:||..:.  |..:.|::...:...| .:..||..:...::.|.|...:.|.:....|...
  Fly   724 SKGTYAFLMETT--NLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGEL 786

  Fly   572 ASVHRK 577
            ..:..|
  Fly   787 FKLRNK 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7f	NP_001138177.1	Periplasmic_Binding_Protein_Type_2	231..>358	CDD:304360	23/133 (17%)
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	32/142 (23%)
		ANF_receptor	41..378	CDD:279440	26/123 (21%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	74/397 (19%)
		Lig_chan	555..822	CDD:278489	50/261 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462670
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740