DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7f and GluRIIA

DIOPT Version :9

Sequence 1:	NP_001138177.1	Gene:	Ir7f / 7354418	FlyBaseID:	FBgn0259188	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	456	Identity:	83/456 - (18%)
Similarity:	160/456 - (35%)	Gaps:	103/456 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 TVLTWHQPPFVELVWDPKHNRSRG----SGFEIQLVEHLARRMNFSLELVNIALLRPNA-YRLAE 289
            ||:|.::.|:..:..|  |...||    .|:.:.|:..|:..|.|..|.:   ::..|. |....
  Fly   430 TVVTHYEEPYFMMKED--HENFRGREKYEGYAVDLISKLSELMEFDYEFM---IVNGNGKYNPET 489

  Fly   290 GSSEGPIEKLLQRNVNISMGYFRKTARRNQLL--TTP--------MSYYS----ANLVAVLQLER 340
            ...:|.|.||:..:..|.:.....|..|..::  |.|        :.|.|    .|..|.|:
  Fly   490 KQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLE--- 551

  Fly   341 YRIGSLALLVFPFELSVWMLLLLALLIHLGIHLPSARRGNEE--DGGGGLQ-------------V 390
                       ||.:.||:.::.|.||.....:..||....|  .....:|             .
  Fly   552 -----------PFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNS 605

  Fly   391 VALLLGAALAR----LPRSWRHRFIAAHWLWASIPLRISYQSLLFHLIRLQLYNTPSFSLDQLLA 451
            ..|::|:.:.:    |||....|.:...|.:.::.:..:|.:.|...:....:.:...||..|:.
  Fly   606 TWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIE 670

  Fly   452 EG---FQGICTANTQRLLLEMPQLARDPDSIQSVDTPFD--WDVLNVLTRNRNRKIFAVANQD-- 509
            :.   |..:...:|.....|            |.||.:.  |:.:    ::.|...|...|::
  Fly   671 QDKVHFGSMRGGSTSLFFSE------------SNDTDYQRAWNQM----KDFNPSAFTSTNKEGV 719

  Fly   510 --------------VTLSFLHSSAHPNAFHVVKQPVNVEYAGMYMPKHSFLYEKMDDDIRRLDAS 560
                          .|.|..::.........:.:.:..::.|:.:|..|.....:...|.:|...
  Fly   720 ARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSER 784

  Fly   561 GFIHA-----WRRASFASVHRKEQVHMTSRRYINHAKLSGIYMVMAGLYLLAGLLFAGEVLLRQR 620
            |.:..     |:..:...    :..|......::..:|.|:::|:||..|:..:|...|.|...:
  Fly   785 GELQKMKNKWWKNHNVTC----DSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQ 845

  Fly   621 N 621
            |
  Fly   846 N 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7f	NP_001138177.1	Periplasmic_Binding_Protein_Type_2	231..>358	CDD:304360	31/145 (21%)
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377
		ANF_receptor	46..386	CDD:279440
		PBP2_iGluR_Kainate	426..796	CDD:270432	71/400 (18%)
		Lig_chan	556..828	CDD:278489	45/291 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462672
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740