DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7f and Gria4

DIOPT Version :9

Sequence 1:	NP_001138177.1	Gene:	Ir7f / 7354418	FlyBaseID:	FBgn0259188	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_001106655.1	Gene:	Gria4 / 29629	RGDID:	61863	Length:	902	Species:	Rattus norvegicus

Alignment Length:	464	Identity:	77/464 - (16%)
Similarity:	169/464 - (36%)	Gaps:	95/464 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 DKLSQMHGCP-------------LTVLTWHQPPFVELVWDPKHNRSRGS----GFEIQLVEHLAR 266
            |||..:...|             :.|.|..:.|:|  ::...|....|:    |:.:.|...:|:
  Rat   394 DKLVLIQDMPTLGNDTAAIENRTVVVTTIMESPYV--MYKKNHEMFEGNDKYEGYCVDLASEIAK 456

  Fly   267 RMNFSLELVNIALLRPNAYRLAEGSSE---GPIEKLLQRNVNISMGYFRKTARRNQLLTTPMSYY 328
            .:....:   ||::....|...:..::   |.:.:|:.....|::.....|..|.:::.....:.
  Rat   457 HIGIKYK---IAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFM 518

  Fly   329 SANL-VAVLQLERYRIGSLALLVFPFELSVWMLLLLALLIHLGIHL---------PSARRGNE-E 382
            |..: :.:.:.::.:.|..:.| .|....:||.::.|   ::|:.:         |......| |
  Rat   519 SLGISIMIKKPQKSKPGVFSFL-DPLAYEIWMCIVFA---YIGVSVVLFLVSRFSPYEWHTEEPE 579

  Fly   383 DGGGG-----------LQVVALLLGAALAR----LPRSWRHRFIAAHWLWASIPLRISYQSLLFH 432
            ||..|           ...:...|||.:.:    .|||...|.:...|.:.::.:..||.:.|..
  Rat   580 DGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAA 644

  Fly   433 LIRLQLYNTPSFSLDQLL--AEGFQGICTANTQRLLLEMPQLARDPDSIQSVDTPFD--WDVL-- 491
            .:.::...:|..|.:.|.  .|...|...:.:.:......::|           .::  |..:
  Rat   645 FLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIA-----------VYEKMWTYMRS 698

  Fly   492 ---NVLTRNRNRKIFAVANQDVTLSFLHSSAHPNAFHVVKQP---------VNVEYAGMYMPKHS 544
               :|.||.....:..|.......:||..|. .|.:...::|         ::.:..|:..||.|
  Rat   699 AEPSVFTRTTAEGVARVRKSKGKFAFLLEST-MNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGS 762

  Fly   545 FLYEKMDDDIRRLDASGFIHA-----WRRASFASVHRKEQVHMTSRRYINHAKLSGIYMVMA--- 601
            .|...::..:.:|:..|.:..     |...........:....||.  ::.:.::|::.::.
  Rat   763 SLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSA--LSLSNVAGVFYILVGGL 825

  Fly   602 GLYLLAGLL 610
            ||.:|..|:
  Rat   826 GLAMLVALI 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7f	NP_001138177.1	Periplasmic_Binding_Protein_Type_2	231..>358	CDD:304360	21/134 (16%)
Gria4	NP_001106655.1	PBP1_iGluR_AMPA_GluR4	28..398	CDD:107383	3/3 (100%)
		ANF_receptor	39..380	CDD:279440
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	66/401 (16%)
		Lig_chan	546..825	CDD:278489	48/295 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900