DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7f and GRIN2A

DIOPT Version :9

Sequence 1:	NP_001138177.1	Gene:	Ir7f / 7354418	FlyBaseID:	FBgn0259188	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	XP_016878661.1	Gene:	GRIN2A / 2903	HGNCID:	4585	Length:	1516	Species:	Homo sapiens

Alignment Length:	816	Identity:	137/816 - (16%)
Similarity:	249/816 - (30%)	Gaps:	333/816 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 IENVLAQLSTTLVVTISTRHLG----------TAHWFEYMMNILMDSWRMVAVQLLRIRPD---- 100
            :..:|..:|:...|.|...|.|          |:.:|::..:|     :..|..:|:|..|
Human   161 VAQMLDFISSHTFVPILGIHGGASMIMADKDPTSTFFQFGASI-----QQQATVMLKIMQDYDWH 220

  Fly   101 ---LVVNPVPG-RKRVSLLMV---DSYQGLLDTNITASNANFDDP-------------------- 138
               ||....|| |:.:|.:..   :|:.|....|:...:.:|:|.
Human   221 VFSLVTTIFPGYREFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSK 285

  Fly   139 ------------------DYYFI---FLQARDHLIPKELQLILDHCLAHFW---LHCNV-----M 174
                              |:::|   .:.....|||||....|.......|   |...|     :
Human   286 DEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGI 350

  Fly   175 IQTAQVEVL-VYTYYPYTADAC-----------QKAYPIPVN-TFDG------------------ 208
            :.||...:| .::|.|....:|           ...:|..|| |:||
Human   351 LTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPRLVV 415

  Fly   209 ------RKW-KASQMFPDKLSQMHG----------CP-----LTVLTWHQPPF--VELVWDP--- 246
                  |:| |..:.....||..|.          |.     |:::|..:.||  ||.: ||
Human   416 IVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDI-DPLTE 479

  Fly   247 -------------KHNRSRG---------SGFEIQLVEHLARRMNFSLELVNIALLRPNAYRLAE 289
                         |.|.|..         .||.|.:::.|:|.:.|:.:|          |.:..
Human   480 TCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDL----------YLVTN 534

  Fly   290 GSS--------EGPIEKLLQRNVNISMGYFRKTARRNQLLTTPMSYYSANLVAVLQLERYRIGSL 346
            |..        .|.|.:::.:...:::|.......|::::...:.:....:..::......:...
Human   535 GKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPS 599

  Fly   347 ALLVFPFELSVWMLLLLALLIHLGI-----------------------HLPSARRGNEEDGGGGL 388
            |.|. ||..|||:::.:.|||...|                       |.||...|
Human   600 AFLE-PFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIG--------- 654

  Fly   389 QVVALLLGAAL-----ARLPRSWRHRFIAAHWLWASIPLRISYQSLLFHLIRLQLYNTPSFSLDQ 448
            :.:.||.|...     .:.|:....:.:.:.|.:.::....||.:           |..:|.:.:
Human   655 KAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTA-----------NLAAFMIQE 708

  Fly   449 LLAEGFQGICTANTQRLLLEMPQLARDPDSIQSVDTPFDWDVLNVLTRNRNRKIFAVANQDVTLS 513
            ...:...|:.....||           |   .....||.:..:...:..||     :.|
Human   709 EFVDQVTGLSDKKFQR-----------P---HDYSPPFRFGTVPNGSTERN-----IRN------ 748

  Fly   514 FLHSSAHPNAFHVVKQPVNVEYAGMYMPKHSFLYEKMDDDI-----RRLDA-------------- 559
                              |..|...||.|  |..:.::|.:     .:|||
Human   749 ------------------NYPYMHQYMTK--FNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGR 793

  Fly   560 ----------SGFIHA-------------WRRASFASV---------------------HRKEQV 580
                      ||:|.|             |:|....::                     |.::..
Human   794 DEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNE 858

  Fly   581 HMTSRRYINHAKLSGIYMVMAGLYLLAGLLFAGEVL 616
            .|:|:..|::  ::|::.::|....|:.:.|..|.|
Human   859 VMSSQLDIDN--MAGVFYMLAAAMALSLITFIWEHL 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7f	NP_001138177.1	Periplasmic_Binding_Protein_Type_2	231..>358	CDD:304360	28/161 (17%)
GRIN2A	XP_016878661.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810