DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7f and GRIN1

DIOPT Version :9

Sequence 1:	NP_001138177.1	Gene:	Ir7f / 7354418	FlyBaseID:	FBgn0259188	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	XP_005266130.1	Gene:	GRIN1 / 2902	HGNCID:	4584	Length:	959	Species:	Homo sapiens

Alignment Length:	740	Identity:	137/740 - (18%)
Similarity:	230/740 - (31%)	Gaps:	294/740 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 ENVLAQL-------STTLVVTISTRHLGTAHWFEYMMNILMDSW------RMVAVQLLRIRPDLV 102
            :||.|.|       :..::::.|.....|.:....|:|:....:      |.::...||..||
Human   223 KNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPD-- 285

  Fly   103 VNPVPGRKRVSLLMVDSYQGLLDTN-ITASNANFDDPDYYFIFLQARDHLIPKELQLILD---HC 163
                               |:|... |...|.:....|...:..||...|:.||  .|.|   .|
Human   286 -------------------GILGLQLINGKNESAHISDAVGVVAQAVHELLEKE--NITDPPRGC 329

  Fly   164 L--AHFW----LHCNVMIQ-------TAQVEVLVYTYYPYTADACQKAYPIPVNTFDGRK----- 210
            :  .:.|    |...|::.       |.:||        :..|..:|.....:.....||
Human   330 VGNTNIWKTGPLFKRVLMSSKYADGVTGRVE--------FNEDGDRKFANYSIMNLQNRKLVQVG 386

  Fly   211 ---------------WKASQMFPDKLSQMHGCPLTVLTWHQPPFV-------------------- 240
                           |...:....:..|| ...|.::|.||.|||
Human   387 IYNGTHVIPNDRKIIWPGGETEKPRGYQM-STRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGD 450

  Fly   241 ---ELVWDPKHNRSRGS----------GFEIQLVEHLARRMNFSLELVNIALLRPNAYRLAEGSS 292
               :::....::.|.||          ||.|.|:..|||.|||:.|:..:|..:.........|:
Human   451 PVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSN 515

  Fly   293 E----GPIEKLLQRNVNISMGYFRKTARRNQLL--TTPMSYYSANLVAVLQLERYRIGSLALLVF 351
            :    |.:.:||....::.:........|.|.:  :.|..|....::...::.|..:.|   .:.
Human   516 KKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDS---FMQ 577

  Fly   352 PFELSVWMLLLLALLIHLGIHL------------PSAR-----RGNEEDGGGGLQVVALLLGAAL 399
            ||:.::|      ||:.|.:|:            |..|     ...|||        ||.|.:|:
Human   578 PFQSTLW------LLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEED--------ALTLSSAM 628

  Fly   400 -------------ARLPRSWRHRFIAAHWLWASIPLRISYQSLLFHLIRLQLYNTPSFSLDQLLA 451
                         ...|||:..|.:...|...::.:..||
Human   629 WFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASY------------------------- 668

  Fly   452 EGFQGICTANTQRLLLEMPQLARDPDSIQSVDTPFDWDVLNVLTRNRN---RKIFAVANQ-DVTL 512
                   |||....|:    |.|..:.|..::.|          |.||   :.|:|...| .|.:
Human   669 -------TANLAAFLV----LDRPEERITGINDP----------RLRNPSDKFIYATVKQSSVDI 712

  Fly   513 SFLHSSAHPNAFHVVKQPVNVEYAGMY--MPKHSFLYEKMDDDIR-----RLDA----------- 559
            .|..               .||.:.||  |.||:  ||...:.|:     :|.|
Human   713 YFRR---------------QVELSTMYRHMEKHN--YESAAEAIQAVRDNKLHAFIWDSAVLEFE 760

  Fly   560 ----------------SGF------IHAWRRASFASVHRK------EQVHMTSRRY--------- 587
                            |||      ...|::....|:.:.      |.:..|..||
Human   761 ASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNA 825

  Fly   588 ---INHAKLSGIYMVMAGLYLLAGL 609
               :....::|::|::|| .::||:
Human   826 PATLTFENMAGVFMLVAG-GIVAGI 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7f	NP_001138177.1	Periplasmic_Binding_Protein_Type_2	231..>358	CDD:304360	33/165 (20%)
GRIN1	XP_005266130.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	37/211 (18%)
		PBP2_iGluR_NMDA_Nr1	416..820	CDD:270437	92/483 (19%)
		CaM_bdg_C0	856..884	CDD:402271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910