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Protein Alignment Ir7f and GRIK2

DIOPT Version :9

Sequence 1:	NP_001138177.1	Gene:	Ir7f / 7354418	FlyBaseID:	FBgn0259188	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	602	Identity:	100/602 - (16%)
Similarity:	209/602 - (34%)	Gaps:	139/602 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 ILMDSWRMVAVQLLRIRPDLVVNPVP---------GRKRVSLLMVDSYQGLLDTNITASNANFDD 137
            ::.|:..:|:|.:.:. |.:.|:.:.         |.:.:||:....::||.. .||.:..|...
Human   322 LMYDAVHVVSVAVQQF-PQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTG-RITFNKTNGLR 384

  Fly   138 PDYYFIFLQARDHLIPKELQLILDHCLAHFWLHCNVMIQTAQVEVLVYTYYPYTADACQKAYPIP 202
            .|:....:..::..:.|                             :.|:.|.:.
Human   385 TDFDLDVISLKEEGLEK-----------------------------IGTWDPASG---------- 410

  Fly   203 VNTFDGRKWKASQMFPDKLSQMHGCPLTVLTWHQPPFV--ELVWDPKHNRSRGSGFEIQLVEHLA 265
            :|..:.:|.|.:.: .|.||..   .|.|.|..:.|:|  :....|.:...|..|:.|.|:..|:
Human   411 LNMTESQKGKPANI-TDSLSNR---SLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELS 471

  Fly   266 RRMNFSLELVNIALLRPNAYRL---AEGSSEGPIEKLLQRNVNISMGYFRKTARRNQLLTTPMSY 327
            ..:.|:.|   |.|:....|..   |.|...|.:.:|:....::::.....|..|.:::.....:
Human   472 TILGFTYE---IRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPF 533

  Fly   328 YSANLVAVLQLERYRIGSLALLVFPFELSVWMLLLLALLIHLGIH---LPSARRG-----NEEDG 384
            .:..:..:.:........:...:.|....:||.:|||   :||:.   ...||..     |....
Human   534 MTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLA---YLGVSCVLFVIARFSPYEWYNPHPC 595

  Fly   385 GGGLQVV----ALL------LGAALAR----LPRSWRHRFIAAHWLWASIPLRISYQSLLFHLIR 435
            .....||    .||      :||.:.:    :|::...|.:...|.:.::.:..||.:.|...:.
Human   596 NPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT 660

  Fly   436 LQLYNTPSFSLDQLLAE---GFQGICTANTQRLLLEMPQLARDPDSIQSVDTPFDWDVLNVLTRN 497
            ::...:|..|.|.|..:   .:..:....|.....:           ..:.|   :|.:.....:
Human   661 VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKK-----------SKIST---YDKMWAFMSS 711

  Fly   498 RNRKIFAVANQDVTLSFLHSSAHPNAFHVVKQPVNVEYA-------------------GMYMPKH 543
            |.:.:...:|::.....|.|.     :..:.:...:|:.                   |:..|..
Human   712 RRQSVLVKSNEEGIQRVLTSD-----YAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMG 771

  Fly   544 SFLYEKMDDDIRRLDASGFIHA-----WRRASFASVHRKEQVHMTSRRYINHAKLSGIYMVMAGL 603
            |...:|:...|.:|...|.:|.     ||.........||      ...:....:.||::|:|..
Human   772 SPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKE------ASALGVQNIGGIFIVLAAG 830

  Fly   604 YLLAGLLFAGEVLLRQR 620
            .:|:..:..||.|.:.:
Human   831 LVLSVFVAVGEFLYKSK 847

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.