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Protein Alignment Ir7f and GRIK1

DIOPT Version :9

Sequence 1:	NP_001138177.1	Gene:	Ir7f / 7354418	FlyBaseID:	FBgn0259188	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_001317923.1	Gene:	GRIK1 / 2897	HGNCID:	4579	Length:	949	Species:	Homo sapiens

Alignment Length:	486	Identity:	81/486 - (16%)
Similarity:	171/486 - (35%)	Gaps:	118/486 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 VNTFDGRKWKASQMFPDKLSQMHGCPLTVLTWHQPPFV--ELVWDPKHNRSRGSGFEIQLVEHLA 265
            :|..|..|.|:|.: .|.|:..   .|.|.|..:.|:|  .....|.:...|..|:.:.|::.|:
Human   427 LNMTDSNKDKSSNI-TDSLANR---TLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELS 487

  Fly   266 RRMNFSLELVNIALLRPNAY--RLAEGSSEGPIEKLLQRNVNISMGYFRKTARRNQLLTTPMSYY 328
            ..:.|   :.::.|:....|  :..:|...|.:::|:....::::.....|..|.:::.....:.
Human   488 NILGF---IYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFM 549

  Fly   329 SANLVAVLQLERYRIGSLALLVFPFELSVWMLLLLALLIHLGIHLPSARRGNEEDGGGGLQVVAL 393
            :..:..:.:........:...:.|....:||.:|||.|                    |:..|..
Human   550 TLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACL--------------------GVSCVLF 594

  Fly   394 LL-----------------------------------GAALAR----LPRSWRHRFIAAHWLWAS 419
            ::                                   ||.:.:    :|::...|.:...|.:.:
Human   595 VIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFT 659

  Fly   420 IPLRISYQSLLFHLIRLQLYNTPSFSLDQLLAEGFQGICTANTQRLLLEMPQLARDPDSI----Q 480
            :.:..||.:.|...:.::...:|..|.|.|            .::..:|...: ||..::    :
Human   660 LIIISSYTANLAAFLTVERMESPIDSADDL------------AKQTKIEYGAV-RDGSTMTFFKK 711

  Fly   481 SVDTPFD--WDVLN-----VLTRNRNRKIFAVANQDVTLSFLHSSAHPNAFHVVKQPVNVEYA-- 536
            |..:.::  |..::     .|.||.:..|..|...|..|....:|..    :|.::..|:...
Human   712 SKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIE----YVTQRNCNLTQIGG 772

  Fly   537 -------GMYMPKHSFLYEKMDDDIRRLDASGFIHA-----WRRASFASVHRKEQVHMTSRRYIN 589
                   |:..|..|...:|:...|.:|...|.:|.     ||.........||      ...:.
Human   773 LIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKE------ASALG 831

  Fly   590 HAKLSGIYMVMAGLYLLAGLLFAGEVLLRQR 620
            ...:.||::|:|...:|:..:..||.:.:.|
Human   832 VENIGGIFIVLAAGLVLSVFVAIGEFIYKSR 862

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.