Protein Alignment Ir7f and GRID1

DIOPT Version :9

• Sequence 1: NP_001138177.1
• Gene: Ir7f / 7354418
• FlyBaseID: FBgn0259188
• Length: 621
• Species: Drosophila melanogaster
• Sequence 2: NP_060021.1
• Gene: GRID1 / 2894
• HGNCID: 4575
• Length: 1009
• Species: Homo sapiens
• Alignment Length: 773
• Identity: 143/773 - (18%)
• Similarity: 251/773 - (32%)
• Gaps: 274/773 - (35%)

  Fly    28 NSRIDMQGEDANLYVARALRL-----VIENVLAQLSTTLVVTISTRHLG---------------- 71
            :|..|::|..:.|..|..|.|     .::..::.:.|:|..|:.|..|.
Human   170 DSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQ 234

  Fly    72 -----------------TAHWF---------EYMMNILMDSWRMVAVQLLRIRPDLVVNPVPGRK 110
                             .:||.         |.:..:.....||..|:  :|.|....|....|.
Human   235 GAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVR--QIFPSAKDNQKCTRN 297

  Fly   111 --RVSLLMVDSYQGLLDTNITASNANFDDPDYYFIFLQARDHLIPKELQLILDHCLAHF------ 167
              |:|.|:.|..:|.|.. :..||....|.   .:.|....|   ::|:....|.:|..
Human   298 NHRISSLLCDPQEGYLQM-LQISNLYLYDS---VLMLANAFH---RKLEDRKWHSMASLNCIRKS 355

  Fly   168 ---WLHCNVMIQT-----------------------AQVEVLVYTYYPYTADACQKAYPIPVNTF 206
               |.....|:.|                       .|.|:|..||               ..||
Human   356 TKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTY---------------SETF 405

  Fly   207 --DGRK---WKASQMFPDKL------SQMHGCPLTVLTWHQPPFV----ELVWDPKHNRSRGSGF 256
              |.||   |.:.:.....|      |::.|..|.|:|..:.|||    .::..||    |..||
Human   406 GKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPK----RYKGF 466

  Fly   257 EIQLVEHLARRMNFSLELVNIALLRPN---AYRLAEGSSEGPIEKLLQRNVNISMGYFRKTARRN 318
            .|.:::.||:.:.|..|:..    .|:   .::|...|..|.|.:|:.:..::::.....|..|.
Human   467 SIDVLDALAKALGFKYEIYQ----APDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERE 527

  Fly   319 QLLTTPMSY--YSANLVAVLQLERYRIGSLALLVFPFELSVWMLLLLALLIHLGIHL-------- 373
            .::.....|  ||..::.....|:..|.|   |..||:.:||..:..|:.: :|:.:
Human   528 SVVDFSKRYMDYSVGILIKKPEEKISIFS---LFAPFDFAVWACIAAAIPV-VGVLIFVLNRIQA 588

  Fly   374 ----------PSARR----------GNEEDGGGGLQVVALLLGAALARLPRSWRHRFIAAHWLWA 418
                      |||..          |.....||...|.::.:...:.    ||        ||:.
Human   589 VRAQSAAQPRPSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMG----SW--------WLFT 641

  Fly   419 SI--------------------PLR----------ISY----QSLLFHLIRLQLYNTPSFSLDQL 449
            .|                    |:|          :||    .|.::...|.:  .|.....|..
Human   642 LIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAK--GTNPLEQDST 704

  Fly   450 LAEGFQGICTANTQRLLLEMPQLARDPDSIQSVDTP-------------FDWDVLNVLTRNRNRK 501
            .||.::.|               :::..:...|.:|             |.|||..|       :
Human   705 FAELWRTI---------------SKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVV-------E 747

  Fly   502 IFAVANQDVTLSFLHSSAHPNAFHVVKQPVNVEYAGMYMPKHSFLYEKMDDDI---------RRL 557
            ..|:.:.|.:::.:.:|.....:.:..|. ...|..::..:...|.:..|.|:         .|.
Human   748 YAALTDDDCSVTVIGNSISSKGYGIALQH-GSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRC 811

  Fly   558 DASGFIHAWRRASFASVHRKEQVHMTSRRYINHAKLSGIYMVMAGLYLLAGLLFAGEV 615
            |.:.  ||..:|...|:    ::|          ..:|::.::|...|||.|:.|.|:
Human   812 DLTS--HASAQADGKSL----KLH----------SFAGVFCILAIGLLLACLVAALEL 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7f	NP_001138177.1	Periplasmic_Binding_Protein_Type_2	231..>358	CDD:304360	32/135 (24%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250|UniProtKB:Q61627	21..436		52/289 (18%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	50/276 (18%)
		ANF_receptor	41..400	CDD:279440	42/238 (18%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	76/418 (18%)
		Lig_chan	564..841	CDD:278489	51/330 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	930..954

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810