DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7f and GRIA3

DIOPT Version :9

Sequence 1:	NP_001138177.1	Gene:	Ir7f / 7354418	FlyBaseID:	FBgn0259188	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_000819.4	Gene:	GRIA3 / 2892	HGNCID:	4573	Length:	894	Species:	Homo sapiens

Alignment Length:	311	Identity:	55/311 - (17%)
Similarity:	116/311 - (37%)	Gaps:	71/311 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 YTADACQKAYPIPVNTFDGRK---WK--------ASQMFPDKLSQMHGCPLTVLTWHQPPFVELV 243
            ||.|    .|.:.|:  ..||   |.        :.|...:..:......:.|.|..:.|:|  :
Human   381 YTID----VYEMKVS--GSRKAGYWNEYERFVPFSDQQISNDSASSENRTIVVTTILESPYV--M 437

  Fly   244 WDPKHNRSRGS----GFEIQLVEHLAR--RMNFSLELVNIALLRPNAYRLAEGSSE---GPIEKL 299
            :...|.:..|:    |:.:.|...:|:  |:.:.|.:|.     ...|...:..::   |.:.:|
Human   438 YKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVG-----DGKYGARDPETKIWNGMVGEL 497

  Fly   300 LQRNVNISMGYFRKTARRNQLLTTPMSYYSANL-VAVLQLERYRIGSLALLVFPFELSVWMLLLL 363
            :....:|::.....|..|.:::.....:.|..: :.:.:.::.:.|..:.| .|....:||.::.
Human   498 VYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFL-DPLAYEIWMCIVF 561

  Fly   364 ALLIHLGI---------------HLPSARRGNEE-----------DGGGGLQVVALLLGAALAR- 401
            |   ::|:               ||..   .|||           :..|....:...|||.:.:
Human   562 A---YIGVSVVLFLVSRFSPYEWHLED---NNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQG 620

  Fly   402 ---LPRSWRHRFIAAHWLWASIPLRISYQSLLFHLIRLQLYNTPSFSLDQL 449
               .|||...|.:...|.:.::.:..||.:.|...:.::...:|..|.:.|
Human   621 CDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7f	NP_001138177.1	Periplasmic_Binding_Protein_Type_2	231..>358	CDD:304360	22/136 (16%)
GRIA3	NP_000819.4	PBP1_iGluR_AMPA_GluR3	35..409	CDD:380610	8/33 (24%)
		PBP2_iGluR_AMPA	422..805	CDD:270433	46/264 (17%)
		Glutamate binding. /evidence=ECO:0000250	508..510		0/1 (0%)
		Glutamate binding. /evidence=ECO:0000250	686..687
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810