DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir7f and Grin2b

DIOPT Version :9

Sequence 1:NP_001138177.1 Gene:Ir7f / 7354418 FlyBaseID:FBgn0259188 Length:621 Species:Drosophila melanogaster
Sequence 2:NP_036706.1 Gene:Grin2b / 24410 RGDID:2738 Length:1482 Species:Rattus norvegicus


Alignment Length:762 Identity:124/762 - (16%)
Similarity:251/762 - (32%) Gaps:261/762 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 GYSIY----KSYLENS----------RIDMQGEDANLYVARALRLVIENVLAQLSTTLVVTISTR 68
            ||..:    :|.:|||          .:||..:|.:        ..|:|.|.:|.:.:::...|:
  Rat   178 GYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGD--------SKIQNQLKKLQSPIILLYCTK 234

  Fly    69 HLGTAHWFEYMMNILMD----SWRMVAVQLLRIRPDLV---VNPVPGRKRVSLLMVDSYQGLLDT 126
            ...| :.||...::.:.    :|         |.|.||   .:.||......|:.|         
  Rat   235 EEAT-YIFEVANSVGLTGYGYTW---------IVPSLVAGDTDTVPSEFPTGLISV--------- 280

  Fly   127 NITASNANFDDPDYYFIFLQARDHLIPKELQLILDHCLAHFWLHCNVMIQTAQVEVL-VYTYYPY 190
                   ::|:.| |.:..:.||.:                     .:|.||..::| .:::.|.
  Rat   281 -------SYDEWD-YGLPARVRDGI---------------------AIITTAASDMLSEHSFIPE 316

  Fly   191 TADACQKA-------------YPIPVNTFDG------------------------RKWKASQMFP 218
            ...:|...             |.|.| ||:|                        |||:....:.
  Rat   317 PKSSCYNTHEKRIYQSNMLNRYLINV-TFEGRNLSFSEDGYQMHPKLVIILLNKERKWERVGKWK 380

  Fly   219 DKLSQM------HGCP---------LTVLTWHQPPFV---------------------ELVWDPK 247
            ||..||      ..||         |:::|..:.|||                     .::.:.|
  Rat   381 DKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIISENK 445

  Fly   248 HNRSRG------SGFEIQLVEHLARRMNFSLELVNIALLRPNAYRLAEGSSEGPIEKLLQRNVNI 306
            .:...|      .||.|.:::.:::.:.|:.:|..:.  .....:...|:..|.|.:::.:...:
  Rat   446 TDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVT--NGKHGKKINGTWNGMIGEVVMKRAYM 508

  Fly   307 SMGYFRKTARRNQLLTTPMSYYSANLVAVLQLERYRIGSLALLVFPFELSVWMLLLLALLIHLGI 371
            ::|.......|::::...:.:....:..::......:...|.|. ||...||:::.:.|||...:
  Rat   509 AVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLE-PFSADVWVMMFVMLLIVSAV 572

  Fly   372 H---------------LPSARRGNEEDGGGGLQV---VALLLGAAL-----ARLPRSWRHRFIAA 413
            .               |...|    |.||....:   :.||.|...     .:.|:....:.:.:
  Rat   573 AVFVFEYFSPVGYNRCLADGR----EPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVS 633

  Fly   414 HWLWASIPLRISYQSLLFHLIRLQLYNTPSFSLDQLLAEGFQGICTANTQR-------------- 464
            .|.:.::....||.:           |..:|.:.:...:...|:.....||              
  Rat   634 VWAFFAVIFLASYTA-----------NLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVP 687

  Fly   465 -----------------LLLEMPQLARDPDSIQSVDTP------FDWDVLNVLT-RNRNRKIFAV 505
                             .:.:..|...| |::.|:.|.      :|..|||.:. |:...|:..:
  Rat   688 NGSTERNIRNNYAEMHAYMGKFNQRGVD-DALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTI 751

  Fly   506 ANQDVTLSFLHSSAHPNAFHVVKQPVNVEYAGMYMPKHSFLYEKMDDDIRRLDASGFIHAWRRAS 570
            .:..|..|..:                    |:.:.|.|....::|..|.:|...|.:.......
  Rat   752 GSGKVFASTGY--------------------GIAIQKDSGWKRQVDLAILQLFGDGEMEELEALW 796

  Fly   571 FASV-HRKEQVHMTSRRYINHAKLSGIYMVMAGLYLLAGLLFAGEVL 616
            ...: |.::...|:|:..|::  ::|::.::.....|:.:.|..|.|
  Rat   797 LTGICHNEKNEVMSSQLDIDN--MAGVFYMLGAAMALSLITFICEHL 841

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir7fNP_001138177.1 Periplasmic_Binding_Protein_Type_2 231..>358 CDD:304360 20/153 (13%)
Grin2bNP_036706.1 PBP1_iGluR_NMDA_NR2 33..393 CDD:107373 50/271 (18%)
PBP2_iGluR_NMDA_Nr2 403..803 CDD:270436 63/438 (14%)
HisJ <459..>542 CDD:223904 10/84 (12%)
Lig_chan 557..829 CDD:278489 47/309 (15%)
Pore-forming. /evidence=ECO:0000269|PubMed:24876489, ECO:0000305|PubMed:24876489 604..623 3/18 (17%)