DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir7f and Grin2a

DIOPT Version :9

Sequence 1:NP_001138177.1 Gene:Ir7f / 7354418 FlyBaseID:FBgn0259188 Length:621 Species:Drosophila melanogaster
Sequence 2:NP_036705.3 Gene:Grin2a / 24409 RGDID:2737 Length:1464 Species:Rattus norvegicus


Alignment Length:601 Identity:103/601 - (17%)
Similarity:188/601 - (31%) Gaps:223/601 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 IENVLAQLSTTLVVTISTRHLG----------TAHWFEYMMNILMDSWRMVAVQLLRIRPD---- 100
            :..:|..:|:...:.|...|.|          |:.:|::..:|     :..|..:|:|..|    
  Rat   109 VAQMLDFISSQTFIPILGIHGGASMIMADKDPTSTFFQFGASI-----QQQATVMLKIMQDYDWH 168

  Fly   101 ---LVVNPVPG-RKRVSLLMV---DSYQGLLDTNITASNANFDDP-------------------- 138
               ||....|| |..:|.:..   :|:.|....|:...:.:|:|.                    
  Rat   169 VFSLVTTIFPGYRDFISFIKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSK 233

  Fly   139 ------------------DYYFI---FLQARDHLIPKELQLILDHCLAHFW---LHCNV-----M 174
                              |:::|   .:.....|||||....|.......|   |...|     :
  Rat   234 DEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGLGI 298

  Fly   175 IQTAQVEVL-VYTYYPYTADAC-----------QKAYPIPVN-TFDG------------------ 208
            :.||...:| .::|.|....:|           ...:...|| |:||                  
  Rat   299 LTTAASSMLEKFSYIPEAKASCYGQAEKPETPLHTLHQFMVNVTWDGKDLSFTEEGYQVHPRLVV 363

  Fly   209 ------RKW-KASQMFPDKLSQMHG----------CP-----LTVLTWHQPPF--VELVWDP--- 246
                  |:| |..:.....||..|.          |.     |:::|..:.||  ||.: ||   
  Rat   364 IVLNKDREWEKVGKWENQTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDI-DPLTE 427

  Fly   247 -------------KHNRSRG---------SGFEIQLVEHLARRMNFSLELVNIALLRPNAYRLAE 289
                         |.|.|..         .||.|.:::.|:|.:.|:.:|          |.:..
  Rat   428 TCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDL----------YLVTN 482

  Fly   290 GSS--------EGPIEKLLQRNVNISMGYFRKTARRNQLLTTPMSYYSANLVAVLQLERYRIGSL 346
            |..        .|.|.:::.:...:::|.......|::::...:.:....:..::......:...
  Rat   483 GKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPS 547

  Fly   347 ALLVFPFELSVWMLLLLALLIHLGI-----------------------HLPSARRGNEEDGGGGL 388
            |.|. ||..|||:::.:.|||...|                       |.||...|         
  Rat   548 AFLE-PFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIG--------- 602

  Fly   389 QVVALLLGAAL-----ARLPRSWRHRFIAAHWLWASIPLRISYQSLLFHLIRLQLYNTPSFSLDQ 448
            :.:.||.|...     .:.|:....:.:.:.|.:.::....||.:           |..:|.:.:
  Rat   603 KAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTA-----------NLAAFMIQE 656

  Fly   449 LLAEGFQGICTANTQR 464
            ...:...|:.....||
  Rat   657 EFVDQVTGLSDKKFQR 672

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir7fNP_001138177.1 Periplasmic_Binding_Protein_Type_2 231..>358 CDD:304360 28/161 (17%)
Grin2aNP_036705.3 PBP1_iGluR_NMDA_NR2 32..392 CDD:107373 51/287 (18%)
PBP2_iGluR_NMDA_Nr2 403..802 CDD:270436 51/302 (17%)
HisJ <458..>541 CDD:223904 13/92 (14%)
Glutamate binding. /evidence=ECO:0000269|PubMed:16281028, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY 511..513 0/1 (0%)
Lig_chan 556..828 CDD:278489 23/137 (17%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:B7ZSK1 599..620 4/29 (14%)
Glutamate binding. /evidence=ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:24462099, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8 689..690
Glutamate binding. /evidence=ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:24462099, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8 730..731
NMDAR2_C 839..1464 CDD:287527
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 989..1083
PDZ-binding. /evidence=ECO:0000305 1462..1464
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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