DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7f and Grik4

DIOPT Version :9

Sequence 1:	NP_001138177.1	Gene:	Ir7f / 7354418	FlyBaseID:	FBgn0259188	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_036704.1	Gene:	Grik4 / 24406	RGDID:	2734	Length:	956	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	96/525 - (18%)
Similarity:	186/525 - (35%)	Gaps:	120/525 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 AHFWLH-CNVMIQTAQVEVLVYT-YYPYTADACQKAYPIPVNTFDGR------KWKA-------S 214
            |..|.| .::|.....||:...| :..:.:...:..|.:.:..|...      :|..       |
  Rat   338 AQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDS 402

  Fly   215 QMFPDKLS-QMHGCPLTVLTWHQPPFVELVWDPK--HNRSRGSGFEIQLVEHLAR--RMNFSLEL 274
            :::...:| .:....|.|.|..:.|::.|..:.:  ....|..||.:.:::.||.  |.|:.:.|
  Rat   403 RLYASNISDSLFNTTLVVTTILENPYLMLKGNHQDMEGNDRYEGFCVDMLKELAEILRFNYKIRL 467

  Fly   275 VNIALLRPNAYRL--AEGSSEGPIEKLLQRNVNISMGYFRKTARRNQLLTTPMSYYSANLVAVLQ 337
            |.     ...|.:  |.|:..|.:.:|:.|..::::.....||.|.:::.....:.:..:..:.:
  Rat   468 VG-----DGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYR 527

  Fly   338 LERYRIGSLALLVFPFELSVWMLLLLALLIHLGIHLPSARRGNEE--------DGGGGLQVVALL 394
            :...|.......:.||...||:.:|||.|....:....||....|        .|...|.|....
  Rat   528 VHMGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYS 592

  Fly   395 LGAAL------------ARLPRSWRHRFIAAHWLWA-SIPLRISYQSLLFHLIRLQLYNTPSFSL 446
            ||.:|            ...||:...|.::..| || ::.:..||.:.|...:.:|....|..|:
  Rat   593 LGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVW-WAFTLIIISSYTANLAAFLTVQRMEVPIESV 656

  Fly   447 DQLLAEG---------------FQGICTANTQRLLLEMPQLARDPDSIQSVDTPFDWDVLNVLTR 496
            |.|..:.               ||.......||:                      |:.:    .
  Rat   657 DDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRM----------------------WNYM----Y 695

  Fly   497 NRNRKIFAVANQDVTLSFLHSSAHPNAFHVVKQPVNVEYA------------------GMYMPKH 543
            ::...:|..:.::.....|:|    |...:::..:|..|.                  |:.||..
  Rat   696 SKQPSVFVKSTEEGIARVLNS----NYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVG 756

  Fly   544 SFLYEKMDDDIRRLDASGFIHAWRRASF-ASVHRKEQVHMTSRRYINHAKLSGIYMVMAGLYLLA 607
            |...::.|..|.:|..:..:...:|..: .....||:.|..  :.:....:.||::|     |:.
  Rat   757 SVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEEDHRA--KGLGMENIGGIFVV-----LIC 814

  Fly   608 GLLFA 612
            ||:.|
  Rat   815 GLIVA 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7f	NP_001138177.1	Periplasmic_Binding_Protein_Type_2	231..>358	CDD:304360	25/132 (19%)
Grik4	NP_036704.1	Periplasmic_Binding_Protein_type1	24..402	CDD:415822	10/63 (16%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	74/405 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810