DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7f and Grin3a

DIOPT Version :9

Sequence 1:	NP_001138177.1	Gene:	Ir7f / 7354418	FlyBaseID:	FBgn0259188	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_001263284.1	Gene:	Grin3a / 242443	MGIID:	1933206	Length:	1135	Species:	Mus musculus

Alignment Length:	667	Identity:	134/667 - (20%)
Similarity:	243/667 - (36%)	Gaps:	182/667 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SIYKSYLENSRIDMQGEDANLYVARAL--RLVIENVLAQLSTTL-VVTISTRHLGTAHWFEYMMN 81
            |:::.|:         :||...||||:  ..:|:..||.|.:|: .:.:.|.:|.:.   :|:..
Mouse   383 SVFEYYV---------QDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSG---QYLSR 435

  Fly    82 ILMDSWRMVAVQLLRIRPDLVV-------------NPVPGRKRVSLLMVDSYQG---LLDTNITA 130
            .|.::........::::...:|             :|: |:...:.|  .|:||   ::|:.|..
Mouse   436 FLANTTFRGLSGSIKVKGSTIVSSENNFFIWNLQYDPM-GKPMWTRL--GSWQGGRIVMDSGIWP 497

  Fly   131 SNA-----NFDDP-----------DYYFIFLQARDH--LIPKELQLILDHCLAHFWLHCNVMIQT 177
            ..|     :|..|           ::.|:|.:..|.  |.|.. ||.||
Mouse   498 EQAQRHKTHFHHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAG-QLCLD---------------- 545

  Fly   178 AQVEVLVYTYYPYTADACQKAYPIPVNTFDGRKWKASQMFPDKLSQMHGCPLTVLTWHQPPFVEL 242
                       |.|.|                    |.:.....|.:|....||
Mouse   546 -----------PMTND--------------------SSILDSLFSSLHSSNDTV----------- 568

  Fly   243 VWDPKHNRSRGSGFEIQLVEHLARRMNFSLELVNIALLRPNAYRLAEGSSEGPIEKLLQRNVNIS 307
               |...:....|:.|.|:|.||..|||..:|..:...:..|::  .|...|.:..||....|::
Mouse   569 ---PIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWK--NGHWTGLVGDLLSGTANMA 628

  Fly   308 MGYFRKTARRNQLLTTPMSYYSANLVAVLQLERYRIGSLALLVFPFELSVWMLLLLAL---LIHL 369
            :..|.....|:|::.....::|.:| .:|...|.....:...::|...::|:.:.:||   .|.|
Mouse   629 VTSFSINTARSQVIDFTSPFFSTSL-GILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFL 692

  Fly   370 GIH--------LPSARRGNEE-DGGGGLQV-VALLLG-AALARLPRSWRHRFIAAHW-LWASIPL 422
            .::        .|..|..|:. .....|.| .|||.| .|..:.|:.|..||:...| ::....|
Mouse   693 TLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCL 757

  Fly   423 RISYQSLLFHLIRLQLYNTPSFSLDQLL---AEGFQ-GICTANT-----QRLLLEMPQLAR---- 474
            .....:|...::..::|...|...|..|   ::||: |....::     ::...||.:..|
Mouse   758 STYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNV 822

  Fly   475 --DPDSIQSVDTPFDWDVLNVLTRNRNRKIFAVANQDVTLSFLHSSAHPNAFHVVKQPVNVEYAG 537
              .||.:|.:             :|...|:.|.......|.:..|.........|.:|..:|..|
Mouse   823 PATPDGVQYL-------------KNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYG 874

  Fly   538 MYMPKHSFLYEKMDDDIRRLDASGFIHA----WRRA------SFASVHRKEQVHMTSRRYINHAK 592
            :.:|.:|.|...:.:.|.:..:.||:..    |.:.      |||       |..|.:..|.|
Mouse   875 IGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFA-------VTETLQMGIKH-- 930

  Fly   593 LSGIYMVMA---GLYLL 606
            .||:::::.   ||.:|
Mouse   931 FSGLFVLLCIGFGLSIL 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7f	NP_001138177.1	Periplasmic_Binding_Protein_Type_2	231..>358	CDD:304360	26/126 (21%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	26/128 (20%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	92/473 (19%)
		Lig_chan	676..942	CDD:278489	60/287 (21%)
		PPP2CB binding site. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	951..987
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810