DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7f and glr-6

DIOPT Version :9

Sequence 1:	NP_001138177.1	Gene:	Ir7f / 7354418	FlyBaseID:	FBgn0259188	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_741822.2	Gene:	glr-6 / 180955	WormBaseID:	WBGene00001617	Length:	844	Species:	Caenorhabditis elegans

Alignment Length:	738	Identity:	145/738 - (19%)
Similarity:	251/738 - (34%)	Gaps:	209/738 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SGYSIYKSYLEN-SRIDMQG--------EDANLYVARALRLVIE---------NVLAQLS--TTL 61
            |.|...|..:|. ||::...        :|:.:..|.|||...:         .||.:||  .||
Worm   157 SNYDAPKQLIETLSRLEKSPALLRAHTLDDSMMATALALRDTCDRNRCWPKKNRVLIELSPNETL 221

  Fly    62 VVTISTRHLGTAHWFEYMMNILMDSWRMVAVQLLRIRPDLVVNPVPGRKRVSLLMV--------- 117
            ....::..||.         |.:.:|.::..  |....|.:........|||||.|
Worm   222 TFFDASLKLGM---------ISVHNWFLITA--LDDLNDHLSQYTHNGMRVSLLTVSKEKWNQND 275

  Fly   118 ------DSYQGLLDTNITASNANFDDPDYYFIF------LQARDHLI--------PKELQLIL-- 160
                  |.||..|..  ..||......|:.|||      .||.|..|        .|:.:|.:
Worm   276 LAIKLPDMYQEYLAK--IPSNPRTPFKDFAFIFDSILLACQAGDRRIISCGDNEAVKKFKLPIVK 338

  Fly   161 ------------------DHCLAHFW--------LHCNVMIQTAQVEVLVYTYYPYTADACQKAY 199
                              |..| |.|        ||..:...|
Worm   339 PFKGLTGKISFNGTSDRSDSEL-HIWEMGITGAGLHTGIWKST---------------------- 380

  Fly   200 PIPVNTFDGRKWKASQ---MFPDKLSQMH---------GCPLTVLTWHQPPFV--ELVWDPKHNR 250
                       |:.|:   |....:...|         ...|.|.:.|:.|:|  :::.|   .|
Worm   381 -----------WEGSKELTMLAKNIPGTHEHYQASVRESRTLKVTSIHEKPYVIEKIMPD---GR 431

  Fly   251 SRGSGFEIQLVEHLARRMNFSLELVNIALLRPNAY-RLAEGSSE--GPIEKLLQRNVNISMGYFR 312
            .:..||.:.|::.||..::|:..|   .:::.|.| ....|:.|  |.|.::|:.:.::::....
Worm   432 IKHEGFCVDLLDKLAEMLHFNYTL---KIVKDNKYGERKNGTDEWDGMIGEILRGDADMAVAPIT 493

  Fly   313 KTARRNQLL--TTPMSYYSANLVAVLQLERYRIGSLALLVFPFELSVWML-----LLLALLIHLG 370
            .||.|.:::  |.|......::: :.|.......||...::|...|||..     ::.|||:.:.
Worm   494 VTATRLEVIDFTDPFLQLGISML-MRQPNPKSSSSLTRFLWPLSASVWTFSAIATVITALLVTVA 557

  Fly   371 IHL-PSARRGNEEDGGGGLQVVALLLGAALARLPRSWRHRFIAAHWLWASIPLRISYQSLLFHLI 434
            ..| |.......:.......:|.:||.|......::...|.|:|.|...::.|...|.:....|:
Worm   558 AVLSPKESTAEFKIQNSVWYLVCILLRAGSGYNCQAGATRLISAVWWSFTLVLIAQYTANFAALL 622

  Fly   435 RLQLYNTPSFSLDQL---LAEGFQGICTANTQ-----------RLLLEMPQLARDPDSIQSVDTP 485
            .:...:.|..|.::|   ....|..|...:|.           |.|.|..|.| :|.:....:..
Worm   623 TVDRKSMPFNSFEELGNQTEYNFGSILGGSTMQFFKYSRIETFRRLWERMQSA-EPSAFVGTNHE 686

  Fly   486 FDWDVLNVLTRNRNRKIFAVANQDVTLSFLHSSAHPNAFHVVKQPVNVEYAG----------MYM 540
            ....|||      .:.:|.:  :..||.:           .|.|..|:...|          :.:
Worm   687 GVNRVLN------EKYVFLM--ESATLDY-----------QVTQNCNLTRVGNVVLGSNGYSIAL 732

  Fly   541 PKHSFLYEKMDDDIRRLDASGFI----HAWRRASFASVHRKEQVHMTSRRYINHAKLSGIYMVMA 601
            ||.|...||:...|..|:..|.|    :.|.:.|.......|...:.:.  :....:.|:::::|
Worm   733 PKGSKWREKLTRQILDLNEKGIILMLKNNWWKKSQQECQSSEPEDLQTA--LGAENVYGLFLLLA 795

  Fly   602 ---GLYLLAGLLFAGEVLLRQRN 621
               |:.:|..:|.....:..::|
Worm   796 LGSGIGVLCAVLEHTHFIFFEKN 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7f	NP_001138177.1	Periplasmic_Binding_Protein_Type_2	231..>358	CDD:304360	30/133 (23%)
glr-6	NP_741822.2	PBP1_iGluR_non_NMDA-like	21..394	CDD:380591	55/283 (19%)
glr-6	NP_741822.2	PBP2_iGluR_Kainate	409..764	CDD:270432	81/381 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910