DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7f and nmr-2

DIOPT Version :9

Sequence 1:	NP_001138177.1	Gene:	Ir7f / 7354418	FlyBaseID:	FBgn0259188	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_001256640.1	Gene:	nmr-2 / 180002	WormBaseID:	WBGene00003775	Length:	990	Species:	Caenorhabditis elegans

Alignment Length:	732	Identity:	130/732 - (17%)
Similarity:	234/732 - (31%)	Gaps:	245/732 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LVIENVLAQLSTTLVVTISTRHLGTAHWFEYMMNILMDSWRMVAVQLLRIRPDLVVNPVPGRKRV 112
            |.:.:|....:..:::..:....||.......|:::.:.:..:..|.::.....|..|
Worm   246 LKLADVKKNQAKIILLYANAAQAGTIFSHAEKMDMIGEKYLWIGTQSVKGTQTTVKAP------- 303

  Fly   113 SLLMVDSYQGLLDTNI-TASNANFDDPDYYFIFLQARDHLIPKELQL---ILDHCLAH------F 167
                  :..|:|..|. |.|||.|          ..||.::|..:||   :....|..      |
Worm   304 ------AQAGMLCVNFHTVSNAMF----------APRDDILPLIIQLAPKLFGAALLQLRPNEMF 352

  Fly   168 WLHCNVMIQTAQVEVLVYTY-------YPYTADACQKAYPIPVN--------TFD---------- 207
            .|..||..::...:    .|       |.:...|..|..|..|:        ||:
Worm   353 SLKSNVSCKSEDGD----PYWDNGKYIYEHMKAAFVKGNPFHVDDGHDSFFYTFEKTGRLRNSIL 413

  Fly   208 ----------GRK-WKASQMFP-------------DKLSQMHGCP----LTVLTWHQPPFVELV- 243
                      |.| |:...:|.             :|.:...|..    :.|:|.|:|||:.:.
Worm   414 QISNLRTNSKGEKTWEKVGIFTNNELKMADVQWPGEKANPPQGAADKFHVKVVTLHEPPFIAVSD 478

  Fly   244 WDPKHNRSRG-----------------------------SGFEIQLVEHLARRMNFSLELVNIAL 279
            .||...:..|                             ||:.:.|:..||..:.|:..|..:
Worm   479 VDPDTQKCPGNQGSICDWGDVEYTDGAGVKKNRTLLKCCSGYCVDLLNKLANDIGFTYTLYKV-- 541

  Fly   280 LRPNAYRL-AEGSSEGPIEKLLQRNVNISMGYFRKTARRNQLLTTPMSYYSANLVAVLQLERYRI 343
             |...:.| .|....|.|..|:....::.:...:..:.|.:.:...:.:....:..::::   |.
Worm   542 -RDEKWGLKTENGWNGLIADLMHNKADMCVTSLKLNSERARDIDFSLPFLDTGISIIVKI---RS 602

  Fly   344 GSLALLVF--PFELSVWMLLLLALLIHLGIHLPSARRGNEEDGGGGLQVVALLLGAALARLPRSW 406
            |.|:...|  |||.|.|:::|. :.||:                           ||::.....|
Worm   603 GVLSPTAFLEPFEYSTWVIILF-VCIHV---------------------------AAISIFLFEW 639

  Fly   407 --------------RHRF--IAAHWL-WAS---------IPLRISYQSLL------FHLIRLQLY 439
                          .|:|  ..::|| ||:         :| :.:...|:      |.|..|.:|
Worm   640 VSPYSFNMQKYPPPEHKFSLFRSYWLVWATLFSASVSTDVP-KSTVSRLMALVWAAFGLTFLAVY 703

  Fly   440 --NTPSFSLDQLLAEGFQGICTANTQRLLLEMPQLARDPDSIQSVD-------TPFDWDVLNVLT 495
              |..:|.:.::......||     ...:|..|...:.|....:||       ...:|..::...
Worm   704 TANLAAFMITRVQYYDLSGI-----HDPMLNFPHDQKPPFRFGTVDGGNTHETMKRNWHKMHEYV 763

  Fly   496 R-------NRNRKIFAVANQD--------VTLSFLHSSAHPNAFHVVKQPVNVEYAGMYMPK--- 542
            :       |.:..|.||.|::        |.|.:........|...|.:..::...|:..||
Worm   764 KHNKYFRMNISAGIEAVKNEELDAFIYDAVVLDYWAGKDANCALMTVGKWASMTGYGIGFPKNSP 828

  Fly   543 ------HSFLYEKMDDDIRRLDASGFIHAW-RRASFASVHRKEQVHMTSRRYINHAKLSGIYMVM 600
                  |..|..:...|:.||.     :.| ..|.....|.:.|          .|.| ||...:
Worm   829 HTSLVNHYMLQYQQKGDLERLQ-----NFWLTGACTPDSHSQTQ----------SAPL-GIENFL 877

  Fly   601 AGLYLLAGLLFAGEVLL 617
            :...||||.:....::|
Worm   878 SAFVLLAGGIIVSVIVL 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7f	NP_001138177.1	Periplasmic_Binding_Protein_Type_2	231..>358	CDD:304360	31/159 (19%)
nmr-2	NP_001256640.1	rSAM_ocin_1	<54..>108	CDD:274893
		Periplasmic_Binding_Protein_type1	102..443	CDD:385651	38/223 (17%)
		Periplasmic_Binding_Protein_Type_2	460..860	CDD:389745	79/444 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910