Protein Alignment Ir7f and Grin2a

DIOPT Version :9

• Sequence 1: NP_001138177.1
• Gene: Ir7f / 7354418
• FlyBaseID: FBgn0259188
• Length: 621
• Species: Drosophila melanogaster
• Sequence 2: NP_032196.2
• Gene: Grin2a / 14811
• MGIID: 95820
• Length: 1464
• Species: Mus musculus
• Alignment Length: 814
• Identity: 133/814 - (16%)
• Similarity: 246/814 - (30%)
• Gaps: 329/814 - (40%)

  Fly    50 IENVLAQLSTTLVVTISTRHLG----------TAHWFEYMMNILMDSWRMVAVQLLRIRPD---- 100
            :..:|..:|:...:.|...|.|          |:.:|::..:|     :..|..:|:|..|
Mouse   109 VAQMLDFISSQTFIPILGIHGGASMIMADKDPTSTFFQFGASI-----QQQATVMLKIMQDYDWH 168

  Fly   101 ---LVVNPVPG-RKRVSLLMV---DSYQGLLDTNITASNANFDDP-------------------- 138
               ||....|| |..:|.:..   :|:.|....|:...:.:|:|.
Mouse   169 VFSLVTTIFPGYRDFISFIKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSK 233

  Fly   139 ------------------DYYFI---FLQARDHLIPKELQLILDHCLAHFW---LHCNV-----M 174
                              |:::|   .:.....|||||....|.......|   |...|     :
Mouse   234 DEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGLGI 298

  Fly   175 IQTAQVEVL-VYTYYPYTADAC-----------QKAYPIPVN-TFDG------------------ 208
            :.||...:| .::|.|....:|           ...:...|| |:||
Mouse   299 LTTAASSMLEKFSYIPEAKASCYGQTEKPETPLHTLHQFMVNVTWDGKDLSFTEEGYQVHPRLVV 363

  Fly   209 ------RKW-KASQMFPDKLSQMHG----------CP-----LTVLTWHQPPF--VELVWDP--- 246
                  |:| |..:.....||..|.          |.     |:::|..:.||  ||.: ||
Mouse   364 IVLNKDREWEKVGKWENQTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDI-DPLTE 427

  Fly   247 -------------KHNRSRG---------SGFEIQLVEHLARRMNFSLELVNIALLRPNAYRLAE 289
                         |.|.|..         .||.|.:::.|:|.:.|:.:|          |.:..
Mouse   428 TCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDL----------YLVTN 482

  Fly   290 GSS--------EGPIEKLLQRNVNISMGYFRKTARRNQLLTTPMSYYSANLVAVLQLERYRIGSL 346
            |..        .|.|.:::.:...:::|.......|::::...:.:....:..::......:...
Mouse   483 GKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPS 547

  Fly   347 ALLVFPFELSVWMLLLLALLIHLGI-----------------------HLPSARRGNEEDGGGGL 388
            |.|. ||..|||:::.:.|||...|                       |.||...|
Mouse   548 AFLE-PFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIG--------- 602

  Fly   389 QVVALLLGAAL-----ARLPRSWRHRFIAAHWLWASIPLRISYQSLLFHLIRLQLYNTPSFSLDQ 448
            :.:.||.|...     .:.|:....:.:.:.|.:.::....||.:           |..:|.:.:
Mouse   603 KAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTA-----------NLAAFMIQE 656

  Fly   449 LLAEGFQGICTANTQRLLLEMPQLARDPDSIQSVDTPFDWDVLNVLTRNRNRKIFAVANQDVTLS 513
            ...:...|:.....||           |   .....||.:..:...:..||     :.|
Mouse   657 EFVDQVTGLSDKKFQR-----------P---HDYSPPFRFGTVPNGSTERN-----IRN------ 696

  Fly   514 FLHSSAHPNAFHVVKQPVNVEYAGMYMPK------------------HSFLYEK--------MDD 552
                              |..|...||.|                  .:|:|:.        .|:
Mouse   697 ------------------NYPYMHQYMTKFNQRGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDE 743

  Fly   553 DIRRLD-ASGFIHA-------------WRRASFASV---------------------HRKEQVHM 582
            ..:.:. .||:|.|             |:|....::                     |.::...|
Mouse   744 GCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVM 808

  Fly   583 TSRRYINHAKLSGIYMVMAGLYLLAGLLFAGEVL 616
            :|:..|::  ::|::.::|....|:.:.|..|.|
Mouse   809 SSQLDIDN--MAGVFYMLAAAMALSLITFIWEHL 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7f	NP_001138177.1	Periplasmic_Binding_Protein_Type_2	231..>358	CDD:304360	28/161 (17%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..392	CDD:107373	51/287 (18%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	71/473 (15%)
		HisJ	<458..>541	CDD:223904	13/92 (14%)
		Lig_chan	556..828	CDD:278489	49/336 (15%)
		NMDAR2_C	839..1464	CDD:287527	1/2 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910