DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir7f and Grin1

DIOPT Version :10

Sequence 1:NP_001138177.1 Gene:Ir7f / 7354418 FlyBaseID:FBgn0259188 Length:621 Species:Drosophila melanogaster
Sequence 2:NP_001359487.1 Gene:Grin1 / 14810 MGIID:95819 Length:959 Species:Mus musculus


Alignment Length:739 Identity:136/739 - (18%)
Similarity:231/739 - (31%) Gaps:292/739 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 ENVLAQL-------STTLVVTISTRHLGTAHWFEYMMNILMDSW------RMVAVQLLRIRPDLV 102
            :||.|.|       :..::::.|.....|.:....|:|:....:      |.::...||..||.:
Mouse   223 KNVTALLMEARDLEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGI 287

  Fly   103 VNPVPGRKRVSLLMVDSYQGLLDTNITASNANFDDPDYYFIFLQARDHLIPKELQLILD---HCL 164
            :                  ||  ..|...|.:....|...:..||...|:.||  .|.|   .|:
Mouse   288 I------------------GL--QLINGKNESAHISDAVGVVAQAVHELLEKE--NITDPPRGCV 330

  Fly   165 --AHFW----LHCNVMIQ-------TAQVEVLVYTYYPYTADACQKAYPIPVNTFDGRK------ 210
              .:.|    |...|::.       |.:||        :..|..:|.....:.....||      
Mouse   331 GNTNIWKTGPLFKRVLMSSKYADGVTGRVE--------FNEDGDRKFANYSIMNLQNRKLVQVGI 387

  Fly   211 --------------WKASQMFPDKLSQMHGCPLTVLTWHQPPFV--------------------- 240
                          |...:....:..|| ...|.::|.||.|||                     
Mouse   388 YNGTHVIPNDRKIIWPGGETEKPRGYQM-STRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDP 451

  Fly   241 --ELVWDPKHNRSRGS----------GFEIQLVEHLARRMNFSLELVNIALLRPNAYRLAEGSSE 293
              :::....::.|.||          ||.:.|:..|||.|||:.|:..:|..:.........|::
Mouse   452 VKKVICTGPNDTSPGSPRHTVPQCCYGFCVDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNK 516

  Fly   294 ----GPIEKLLQRNVNISMGYFRKTARRNQLL--TTPMSYYSANLVAVLQLERYRIGSLALLVFP 352
                |.:.:||....::.:........|.|.:  :.|..|....::...::.|..:.|   .:.|
Mouse   517 KEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDS---FMQP 578

  Fly   353 FELSVWMLLLLALLIHLGIHL------------PSAR-----RGNEEDGGGGLQVVALLLGAAL- 399
            |:.::|      ||:.|.:|:            |..|     ...|||        ||.|.:|: 
Mouse   579 FQSTLW------LLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEED--------ALTLSSAMW 629

  Fly   400 ------------ARLPRSWRHRFIAAHWLWASIPLRISYQSLLFHLIRLQLYNTPSFSLDQLLAE 452
                        ...|||:..|.:...|...::.:..||                          
Mouse   630 FSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASY-------------------------- 668

  Fly   453 GFQGICTANTQRLLLEMPQLARDPDSIQSVDTPFDWDVLNVLTRNRN---RKIFAVANQ-DVTLS 513
                  |||....|:    |.|..:.|..::.|          |.||   :.|:|...| .|.:.
Mouse   669 ------TANLAAFLV----LDRPEERITGINDP----------RLRNPSDKFIYATVKQSSVDIY 713

  Fly   514 FLHSSAHPNAFHVVKQPVNVEYAGMY--MPKHSFLYEKMDDDIR-----RLDA------------ 559
            |..               .||.:.||  |.||:  ||...:.|:     :|.|            
Mouse   714 FRR---------------QVELSTMYRHMEKHN--YESAAEAIQAVRDNKLHAFIWDSAVLEFEA 761

  Fly   560 ---------------SGF------IHAWRRASFASVHRK------EQVHMTSRRY---------- 587
                           |||      ...|::....|:.:.      |.:..|..||          
Mouse   762 SQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAP 826

  Fly   588 --INHAKLSGIYMVMAGLYLLAGL 609
              :....::|::|::|| .::||:
Mouse   827 ATLTFENMAGVFMLVAG-GIVAGI 849

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir7fNP_001138177.1 Periplasmic_Binding_Protein_Type_2 231..>358 CDD:473866 32/165 (19%)
Grin1NP_001359487.1 PBP1_iGluR_NMDA_NR1 25..404 CDD:380602 37/210 (18%)
PBP2_iGluR_NMDA_Nr1 416..820 CDD:270437 91/483 (19%)
CaM_bdg_C0 856..884 CDD:402271
Blue background indicates that the domain is not in the aligned region.

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