DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7f and Grik3

DIOPT Version :9

Sequence 1:	NP_001138177.1	Gene:	Ir7f / 7354418	FlyBaseID:	FBgn0259188	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_001074566.1	Gene:	Grik3 / 14807	MGIID:	95816	Length:	919	Species:	Mus musculus

Alignment Length:	463	Identity:	87/463 - (18%)
Similarity:	168/463 - (36%)	Gaps:	99/463 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 PDKLSQMHGCPLTVLTWHQPPFVELVWDPK--HNRSRGSGFEIQLVEHLARRMNFSLELVNIALL 280
            |:....:....|.|.|..:.|||......:  :...|..|:.|.|::.||..:.||.|   |.|:
Mouse   425 PNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYE---IRLV 486

  Fly   281 RPNAYRLAE--GSSEGPIEKLLQRNVNISMGYFRKTARRNQLLTTPMSYYSANLVAVLQLERYRI 343
            ....|...:  |...|.:::|:....::::.....|..|.:.:.....:.:..:..:.:......
Mouse   487 EDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTN 551

  Fly   344 GSLALLVFPFELSVWMLLLLALLIHLGIH---LPSARRGNEE--DG---GGGLQVV----ALL-- 394
            .|:...:.|....:||.:|||   :||:.   ...||....|  |.   ..|.:||    .||
Mouse   552 PSVFSFLNPLSPDIWMYVLLA---YLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNS 613

  Fly   395 ----LGAALAR----LPRSWRHRFIAAHWLWASIPLRISYQSLLFHLIRLQLYNTPSFSLDQLLA 451
                :|:.:.:    :|::...|.|...|.:.::.:..||.:.|...:.::...:|..|.|.|
Mouse   614 FWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDL-- 676

  Fly   452 EGFQGICTANTQRLLLEMPQLARDPDSI----QSVDTPFD--WDVL----NVLTRNRNRKIFAVA 506
                      .::..:|...: :|..::    :|..:.|:  |..:    :.|.:|....|....
Mouse   677 ----------AKQTKIEYGAV-KDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTL 730

  Fly   507 NQDVTLSFLHSSAHPNAFHVVKQPVNVEYA-------------------GMYMPKHSFLYEKMDD 552
            ..|..|              :.:...:||.                   |:..|..|...:|:..
Mouse   731 TADYAL--------------LMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITI 781

  Fly   553 DIRRLDASGFIHA-----WRRASFASVHRKEQVHMTSRRYINHAKLSGIYMVMAGLYLLAGLLFA 612
            .|.:|.....:|.     ||.:.......||      ...:...|:.||::|:|...:|:.|:..
Mouse   782 AILQLQEEDKLHIMKEKWWRGSGCPEEENKE------ASALGIQKIGGIFIVLAAGLVLSVLVAV 840

  Fly   613 GEVLLRQR 620
            ||.:.:.|
Mouse   841 GEFIYKLR 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7f	NP_001138177.1	Periplasmic_Binding_Protein_Type_2	231..>358	CDD:304360	24/130 (18%)
Grik3	NP_001074566.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	72/400 (18%)
		Glutamate binding. /evidence=ECO:0000250	690..692		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810