DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7f and GRIN3A

DIOPT Version :9

Sequence 1:	NP_001138177.1	Gene:	Ir7f / 7354418	FlyBaseID:	FBgn0259188	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_597702.2	Gene:	GRIN3A / 116443	HGNCID:	16767	Length:	1115	Species:	Homo sapiens

Alignment Length:	661	Identity:	131/661 - (19%)
Similarity:	233/661 - (35%)	Gaps:	170/661 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SIYKSYLENSRIDMQGEDANLYVARAL--RLVIENVLAQLSTTL-VVTISTRHLGTAHWFEYMMN 81
            |:::.|:         :||...||||:  ..:|:..||.:.:|: .:.:.|.:|.:..:
Human   383 SVFEHYV---------QDAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTSGQY------ 432

  Fly    82 ILMDSWRMVAVQLLRIRPDLVVNPVPGRKRVSLLMVDSYQGLLDTNITASNANFDDPDYYFIFLQ 146
                        |.|...:.....:.|..||.           .:.|.:|..||      ||:..
Human   433 ------------LSRFLANTTFRGLSGSIRVK-----------GSTIVSSENNF------FIWNL 468

  Fly   147 ARDHLIPKELQLILDHCLAHFWLHCNVMIQTAQVEVLVYTYYPYTADACQKAYPIPVNTFDGRKW 211
            ..|.: .|.:...|..     |       |..:: |:.|..:|..|                ::.
Human   469 QHDPM-GKPMWTRLGS-----W-------QGGKI-VMDYGIWPEQA----------------QRH 503

  Fly   212 KASQMFPDKLSQMHGCPLTVLTWHQPPFV--------------ELVWDPKHNRSRG--------- 253
            |.....|.||.      |.|:|..:.|||              :|..||..|.|..
Human   504 KTHFQHPSKLH------LRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLH 562

  Fly   254 --------------SGFEIQLVEHLARRMNFSLELVNIALLRPNAYRLAEGSSEGPIEKLLQRNV 304
                          .|:.|.|:|.:|..|||..:|..:...:..|::  .|...|.:..||:...
Human   563 SSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWK--NGHWTGLVGDLLRGTA 625

  Fly   305 NISMGYFRKTARRNQLLTTPMSYYSANLVAVLQLERYRIGSLALLVFPFELSVWMLLLLALLI-- 367
            ::::..|.....|:|::.....::|.:| .:|...|.....:...::|...::|:.:.:||.|
Human   626 HMAVTSFSINTARSQVIDFTSPFFSTSL-GILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITA 689

  Fly   368 ----------HLGIHLPSARRGNEEDGGGGLQV-VALLLGAALA-RLPRSWRHRFIAAHW-LWAS 419
                      ..|:......|.........|.: .|||.|..:| :.|:.|..||:...| ::..
Human   690 VFLTLYEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCM 754

  Fly   420 IPLRISYQSLLFHLIRLQLYNTPSFSLDQLLAEGFQGICTANTQRLLLE------MPQLARDPDS 478
            ..|.....:|...::..::|...|...|..|....||......:....|      .|::   .:.
Human   755 FCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEM---HEY 816

  Fly   479 IQSVDTPFDWDVLNVLTRNRNRKIFAVANQDVTLSFLHSSAHPNAFHVVKQPVNVEYAGMYMPKH 543
            ::..:.|...|.:..| :|...|:.|.......|.:..|.........|.:|..:|..|:.:|.:
Human   817 MRRYNVPATPDGVEYL-KNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPN 880

  Fly   544 SFLYEKMDDDIRRLDASGF---IH-AWRRA------SFASVHRKEQVHMTSRRYINHAKLSGIYM 598
            |.|...:.:.|.:..:.||   :| .|.|.      |||       |..|.:..|.|  .||:::
Human   881 SPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFA-------VTETLQMGIKH--FSGLFV 936

  Fly   599 VMA---GLYLL 606
            ::.   ||.:|
Human   937 LLCIGFGLSIL 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7f	NP_001138177.1	Periplasmic_Binding_Protein_Type_2	231..>358	CDD:304360	32/163 (20%)
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	32/171 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..118
		ANF_receptor	127..469	CDD:279440	25/129 (19%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	81/408 (20%)
		Lig_chan	676..942	CDD:278489	57/278 (21%)
		PPP2CB binding site. /evidence=ECO:0000250	951..987
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1062..1095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810