DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7f and grin2ca

DIOPT Version :9

Sequence 1:	NP_001138177.1	Gene:	Ir7f / 7354418	FlyBaseID:	FBgn0259188	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_001352716.1	Gene:	grin2ca / 100003342	ZFINID:	ZDB-GENE-070822-3	Length:	1400	Species:	Danio rerio

Alignment Length:	747	Identity:	138/747 - (18%)
Similarity:	257/747 - (34%)	Gaps:	227/747 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GYSIY----KSYLENS----------RIDMQGEDANLYVARALRLVIENVLAQLSTTLVVTIS-- 66
            ||..|    :|:::.|          ..||..:..|...||.|   ::.:.||:   |:|..|
Zfish   183 GYDTYVDYIRSFIDTSYFLWELQDTLTFDMSADGMNDLRARRL---LQQIDAQV---LLVYCSHD 241

  Fly    67 --------TRHLGTAH----WF------------------EYMMNILMDSWRMVAVQLLRIRPDL 101
                    .|.:|...    ||                  ..:::|:.|.|:|.....:|....:
Zfish   242 EAQYLFSMAREVGLVGPGYIWFIPSLAVGNPNIAPPDSFPVGLISIITDRWKMSLRNRVRDGVAI 306

  Fly   102 VVNPVPGRKRVSLLMVDSYQGLLDTNITAS---------NANFDDPDYYFIFLQARDHLI-PKEL 156
            ||..|...::....:.|.:...|.....||         |.::::.|:.|   .:..:|: |..:
Zfish   307 VVKGVESFRKQRGFIPDGHMDCLSPIRPASNGTLYRHMLNVSWENTDFSF---NSDGYLVNPSMI 368

  Fly   157 QLILDHCLAHFWLHCNVMIQTAQVEVLVYTYYPYTADACQKAYPIPVNTFDGRKWKASQMFPDKL 221
            .:.||.  ...|....                .|.:...|..||:         |.....|.:.:
Zfish   369 IITLDR--GRQWDKVG----------------NYESGILQMRYPV---------WPRYGTFLEPV 406

  Fly   222 S-QMHGCPLTVLTWHQPPF--VELVWDP--------------KHNRSRG-------------SGF 256
            | ..|   |||.|..:.||  ||.| ||              :.|::..             .||
Zfish   407 SDNRH---LTVATLEERPFVIVEAV-DPVTGTCLSNTVPCRRQSNKTETIVGHTEPYTKLCCKGF 467

  Fly   257 EIQLVEHLARRMNFSLELVNIALLRPNAYRLAEGSSEGPIEKLLQRNVNISMGYFRKTARRNQLL 321
            .|.:::.|:|.:.||.:|..:.  .....:|..|...|.|.::..:..::::|.......|::::
Zfish   468 CIDILKKLSRNIKFSYDLYLVT--NGKHGKLVRGIWNGMIGEVFYKRADMAIGSLTINEERSEII 530

  Fly   322 TTPMSYYSANLVAVLQLERYRIGSLALLVFPFELSVWMLLLLALLIHLGI--------------- 371
            ...:.:....:..::......:...|.|. |:..:||:::.:..|..:.:
Zfish   531 DFSVPFVETGISVMVARSNGTVSPSAFLE-PYSPAVWVMMFVMCLTVVAVTVFVFEYCSPVGYNR 594

  Fly   372 HLPSARRGNEEDGGGGL----QVVALLLGAAL-----ARLPRSWRHRFIAAHWLWASIPLRISY- 426
            .|.||:     |.||..    :.|.||.|...     ...|:....:.:...|.:.::....||
Zfish   595 SLVSAK-----DPGGPTFTIGKSVWLLWGIVFNNSVPIENPKGTTSKIMVLVWAFFAVIFLASYT 654

  Fly   427 QSLLFHLIRLQLYNTPSFSLDQLLAE--------GFQGICTANTQR-LLLEMPQLARD------- 475
            .:|...:|:.|..:|.|...|:...:        .|..:...:|:| :....|::...
Zfish   655 ANLAAFMIQEQYIDTVSGLSDKKFQKPQDQYPPFRFGTVPNGSTERNIRSNYPEMHSHMVKYNQK 719

  Fly   476 --PDSIQSVDTP------FDWDVLNV---------LTRNRNRKIFAVANQDVTLSFLHSSAHPNA 523
              .|::.|:.|.      :|..|||.         |....:.|:||.....:.|.  ..|..
Zfish   720 GVEDALNSLKTGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIALQ--KESRW--- 779

  Fly   524 FHVVKQPVNVEYAGMYMPKHSFLYEKMDDDIRRLDASGFIHAWRRASFASVHRKEQVHMTSRRYI 588
                |:|:::          :.|....|.|.::|..     .|    ...:.|.|:..:.|.: :
Zfish   780 ----KRPIDL----------ALLQFLADGDTQKLQT-----VW----LTGICRNEKKEVMSSK-L 820

  Fly   589 NHAKLSGIY---MVMAGLYLLAGLLFAGEVLL 617
            :...::|::   :|..||.|   |:||.|.||
Zfish   821 DIDNMAGVFYMLLVAMGLSL---LVFAWEHLL 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7f	NP_001138177.1	Periplasmic_Binding_Protein_Type_2	231..>358	CDD:304360	27/155 (17%)
grin2ca	NP_001352716.1	PBP1_iGluR_NMDA_NR2	38..398	CDD:107373	45/250 (18%)
		PBP2_iGluR_NMDA_Nr2	409..810	CDD:270436	77/440 (18%)
		NMDAR2_C	847..>938	CDD:313729	2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900