DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7e and grik1a

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	XP_009303592.1	Gene:	grik1a / 798001	ZFINID:	ZDB-GENE-030131-6502	Length:	919	Species:	Danio rerio

Alignment Length:	450	Identity:	89/450 - (19%)
Similarity:	151/450 - (33%)	Gaps:	140/450 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 EEVLRVNGGYEG---RLLLALAEKMNFTIAVRKV------HVNMRDEALEMLRR--DEV-DLTLG 282
            ::||..|..:||   .||..|:..:.||..|:.|      ..|.:.|...|:|.  |.: ||.:.
Zfish   466 DKVLYGNDRFEGYCLDLLKELSNILGFTYEVKLVTDGKYGAQNDKGEWNGMVRELIDHIADLAVA 530

  Fly   283 GIRQTVARGMVATSSHNYHQTREVFGVLASS--YELSS------FDILFYPYRLQIWMGI-LGVV 338
            .:..|..|..|...|       :.|..|..|  |...:      |..| .|....|||.: |..:
Zfish   531 PLTITYVREKVIDFS-------KPFMTLGISILYRKPNGTNPGVFSFL-NPLTPDIWMYVLLACL 587

  Fly   339 ALSALIQLIVGRMLRERMGSRF----WLN-----------------LELVFVGMPLLE------C 376
            .:|.::.:|          :||    |.|                 |..::.|:..|.      .
Zfish   588 GVSCVLFVI----------ARFTPYEWYNPHPCNPSSEVVENNFTLLNSLWFGVAALMRQGSELM 642

  Fly   377 PRSHTARLYCVMLMMYTLIIRTIYQGLLYHLIRTHQLNRWPQTIESL----------VQKNFTVV 431
            |::.:.|:...:...:||||.:.|...|...:...:::....:.:.|          |:...|:.
Zfish   643 PKALSTRILGGIWWFFTLIIISSYTANLAAFLTVERMDSPIDSADDLAKQTRIEYGAVRDGSTMT 707

  Fly   432 L---------------------TPIVQEVLDEIPSVQHMRFRLLEANSELDPLYFLEANHQLRQH 475
            .                     |.:|:...|.|..|....:.||..::.::  |..:.|..|.|
Zfish   708 FFKKSKISTYEKMWAFMSSRKNTALVKNSKDGITRVLTTDYALLMESTSIE--YITQRNCNLTQ- 769

  Fly   476 VTASALDIFIHFNRLSADKVHQRGEQGSGAHFEIVPEDIISMQLTMYLAKHSFLIDQLNEEIMWM 540
             ....:|                 .:|.|....|.         :.|..|.:..|.||.||
Zfish   770 -VGGLID-----------------SKGYGVGTPIG---------SPYRDKVTIAILQLQEE---- 803

  Fly   541 RSVGLLSV----WSRWELSESYLRNEQSFQVLGTMELYAIFLMVLVGLIVGLLVFILELV 596
               |.|.:    |  |..:.....:.:....||...:..||:::..||::.:.|.|.|.:
Zfish   804 ---GKLHMMKEKW--WRGNGCPEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFI 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	25/94 (27%)
grik1a	XP_009303592.1	Periplasmic_Binding_Protein_Type_1	37..432	CDD:299141
		ANF_receptor	57..398	CDD:279440
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:304360	79/405 (20%)
		Lig_chan	577..846	CDD:278489	54/317 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591602
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740