DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7e and grin2aa

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	XP_021329529.1	Gene:	grin2aa / 563297	ZFINID:	ZDB-GENE-070424-129	Length:	1460	Species:	Danio rerio

Alignment Length:	779	Identity:	131/779 - (16%)
Similarity:	236/779 - (30%)	Gaps:	295/779 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 NKMMSTLFREWGLA----PLQIVNVLRGVPWH-------PVPGRRHFNVIF----TDSFAAFE-- 107
            :|.:.:.|.::|.:    .|.::|::....||       ..||.:.|..|.    .:||..::
Zfish   134 DKDVKSTFFQFGASIQQEALLMLNIMEEYDWHVFSIVTSKFPGYQDFIAILKTTVDNSFVGWDLQ 198

  Fly   108 --------------EIRME---------YYSREYNYNEHYFIFLQARDRLLQGEMRLIFDYCW-- 147
                          :|:::         |.|::    |..:|..:||...|.|     |.|.|
Zfish   199 HIITLDAVDGDSRTQIQLKKVQSPVVLLYCSKD----EAAYILEEARSLGLTG-----FGYIWIV 254

  Fly   148 ---------------------------------RYR-----LIHCSIQVQKSNGDILFYSYYPFG 174
                                             |.|     :...:..:.:..|||.......:|
Zfish   255 PSLTTGNPEITPDTFPSGMISVSYDDWDYPLEARVRDGLGIITTAAAAMLEEFGDIPEAKTSCYG 319

  Fly   175 EHGCSDMEPQLINRY------------------------------------------NGSMLVEP 197
            :...:.:.|..:::|                                          |.|:.::.
Zfish   320 QMEKTKLPPSALHKYMMNVTWDGKDLSFTEDGYQVHPKLVVIVLNKDREWEKMGKWENQSLTLKY 384

  Fly   198 DLFPRKLRNFFGCP------LRCALWDVPPFLTLDEDQEEVLRVNG------------------- 237
            .::||  .|.||..      |.....:..||:.:    |.|.|:.|
Zfish   385 PVWPR--FNSFGDAETDDNHLTIVTLEEKPFVIV----ENVERLTGTCMRNSVPCRKHIKDNTTE 443

  Fly   238 -----------GYEGRLLLALAEKMNFTIAV---------RKVHVNMRDEALEMLRRDEVDLTLG 282
                       |:...:|..:|..:.||..:         :|::........|::.:..| :.:|
Zfish   444 GGGTYIKKCCKGFCIDILKKIARNVKFTYDLYLVTNGKHGKKINNVWNGMVGEVVNKKAV-MAVG 507

  Fly   283 GIRQTVARGMVATSSHNYHQTREVFGVLASSYELSSFDILFYPYRLQIW----MGILGVVALSAL 343
            .:.....|..|...|..:.:|.....|..|:..:|....| .|:...:|    :.:|.|.|::..
Zfish   508 SLTINEERSEVIDFSVPFVETGISVMVSRSNGTVSPSAFL-EPFSASVWVMMFVMLLLVTAMAVF 571

  Fly   344 I-----QLIVGRMLRE---------RMGSRFWLNLELVFVGMPLLECPRSHTARLYCVMLMMYTL 394
            :     .|...|.|.:         .||...||...|||.....::.|:..|::....:...:.:
Zfish   572 MFEYISPLGFNRNLAQGKDPHGPSFTMGKAVWLLWGLVFNNSVPVQNPKGTTSKFIVSVWAFFAV 636

  Fly   395 IIRTIYQGLLYHLIRTHQLNRWPQTIESLVQKNFTVVLTPIVQEVLDEIPSVQHMRFRLLEANSE 459
            |....|...|...:                          |.:|.:|::..:...:|:  ...|.
Zfish   637 IFLASYTANLAAFM--------------------------IQEEFVDQVTGLSDKKFQ--SPYSY 673

  Fly   460 LDPLYF-------LEAN--------HQ--LRQHVT----------ASALDIFIH----FNRLSA- 492
            ..|..|       .|.|        ||  ::.|.|          ...||.||:    .|.::.
Zfish   674 SPPFRFGTVPNGSTERNIRKNYPDMHQYMVKYHQTGVNDALVSLKTGKLDAFIYDAAVLNYMAGR 738

  Fly   493 DKVHQRGEQGSGAHFEIVPEDIISMQLTMYLAKHSFLIDQLNEEIMWMRSVGL--LSVWSRWELS 555
            |:..:....|||..|......|                 .|.:..:|.|.|.|  |::....|:.
Zfish   739 DEGCKLVTIGSGYIFATTGYGI-----------------ALQKGSLWKRPVDLAILAIIGDGEME 786

  Fly   556 E---SYL-------RNEQSFQVLGTMELYAIFLMVLVGLIVGLLVFILE-LVSMRSIYLRKLFT 608
            |   .:|       :||.....|....:..:|.|:...:.:.|:.|:.| |...|   ||..||
Zfish   787 ELEAQWLTGICHNEKNEVMSSQLDVDNMAGVFYMLATAMGLSLITFVWEHLFYWR---LRYCFT 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	20/133 (15%)
grin2aa	XP_021329529.1	PBP1_iGluR_NMDA_NR2	33..389	CDD:107373	35/263 (13%)
		PBP2_iGluR_NMDA_Nr2	400..799	CDD:270436	77/449 (17%)
		NMDAR2_C	836..1460	CDD:313729	6/15 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591455
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740