DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7e and grin2bb

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_001121809.1	Gene:	grin2bb / 559976	ZFINID:	ZDB-GENE-061207-27	Length:	1770	Species:	Danio rerio

Alignment Length:	408	Identity:	70/408 - (17%)
Similarity:	143/408 - (35%)	Gaps:	104/408 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 RVNGGYEGRLLLALAEKMNFTIAVRKVHVNMRDEALEMLRRDEVDLTLGGIRQTVARGMVATSSH 298
            ::||.:.|         |...:.::..|:.:....:...|.:.:|.::..| :|....||:.|:
Zfish   568 KINGTWNG---------MVGEVVLKNAHMAVGSLTINEERSEVIDFSVPFI-ETGISVMVSRSN- 621

  Fly   299 NYHQTREVFGVLASSYELSSFDILFYPYRLQIWMGILGVVALSALIQLIV---------GRMLRE 354
                     |.::.|..|.       |:...:|:.:..::.:.:.:.:.|         .|.|.:
Zfish   622 ---------GTVSPSAFLE-------PFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLAD 670

  Fly   355 ---------RMGSRFWLNLELVFVGMPLLECPRSHTARLYCVMLMMYTLIIRTIY-QGLLYHLIR 409
                     .:|...||...|||.....::.|:..|:::...:...:.:|....| ..|...:|:
Zfish   671 GREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQ 735

  Fly   410 THQLNRWPQTIESLVQKNFTVVLTPIVQEVLDEIP-----------SVQHMRFRLLEANSELDPL 463
            ...:::    :..|..|.|        |...|..|           :.:::|....|.:|.:...
Zfish   736 EEYVDQ----VTGLSDKKF--------QHPNDFSPPFRFGTVPNGSTERNIRNNYKEMHSYMTSF 788

  Fly   464 YFLEANHQLRQHVTASALDIFIH----FNRLSA-DKVHQRGEQGSGAHFEIVPEDIISMQLTMYL 523
            :....|..|.. :.:..||.||:    .|.::. |:..:....|||..|......|
Zfish   789 HQKNVNEALHS-LKSGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGYIFATTGYGI--------- 843

  Fly   524 AKHSFLIDQLNEEIMWMRSVGL--LSVWSRWELSESYL----------RNEQSFQVLGTMELYAI 576
                    .:.::..|.|:|.|  |.::...|:.|...          :||.....|....:..:
Zfish   844 --------AIQKDSGWKRAVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDVDNMAGV 900

  Fly   577 FLMVLVGLIVGLLVFILE 594
            |.|:...:.:.|:.||.|
Zfish   901 FYMLGAAMALSLITFIAE 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	13/78 (17%)
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..470	CDD:107373
		ANF_receptor	138..442	CDD:279440
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	61/370 (16%)
		Lig_chan	636..908	CDD:278489	50/301 (17%)
		NMDAR2_C	919..1770	CDD:287527	70/408 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591417
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740