DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7e and grid1b

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	XP_009304811.1	Gene:	grid1b / 557511	ZFINID:	ZDB-GENE-121214-84	Length:	1048	Species:	Danio rerio

Alignment Length:	717	Identity:	136/717 - (18%)
Similarity:	249/717 - (34%)	Gaps:	183/717 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NISALLNSYY-DLSGEQMNHINEFVARAVLHVVHHYILS-------VTPSLVLTLCCRSNHTCNF 58
            |||.:.:|.: .:..|::|...:.:.||:|      :||       :..::...|..:.:|....
Zfish   200 NISGVFSSLFTSMRTEELNRYRDTLRRAIL------LLSPRGAQVFIHQAVETNLASKDSHWVFV 258

  Fly    59 YNKMMSTLFREWGLAPLQIVNVLRGVPWHPVPGRRHFNVIFTDSFAAFEEIRMEYYSREYNYNEH 123
            ..::..|...|...:.|..:.|:|.:    .|       ::.||..:.........|...:..|.
Zfish   259 NEEISDTEILELAHSSLGRMTVVRQI----FP-------LWRDSSVSCMRNSHRISSLLCDPQEG 312

  Fly   124 YFIFLQARDRLLQGEM--------RLIFDYCWR-YRLIHCSIQVQKS----NGDILFYSYYPFGE 175
            |...|:..:..|...:        |.:.|..|. ...::|   ::||    ||
Zfish   313 YLQSLEVSNLYLYDSVLMLANAFYRKLEDRKWHSMASLNC---IRKSTKPWNG------------ 362

  Fly   176 HGCSDMEPQLINRYNG------------SMLVEPDLFPRKLRNFFGCPL-RCALWD--------- 218
             |.|.:|.....|..|            :..|:.::........||..: |.|.||
Zfish   363 -GWSMLETIQKGRITGLTGIMDFMENGSNSHVQFEILGTSFSETFGKDIKRLATWDSVHGLNGSL 426

  Fly   219 ------------VPPFLTLDED-----QEEVLRVNGGYEG---RLLLALAEKMNFTIAVRKVHVN 263
                        ....:||.||     .|.:|.....|:|   .:|.|||:.:.|...:.:|..:
Zfish   427 KESRIENGMQGVTVKVVTLLEDPFVMVAENILGQPKRYKGFSIDVLEALAKILGFKYDIYQVADS 491

  Fly   264 MRDEAL----------EMLRRDEVDLTLGGIRQTVARGMVATSSHNYHQTREVFGVLASSYE--L 316
            .....|          |::.: ..||.:..|..|..|..|...|..|....  .|:|....|  :
Zfish   492 KYGSQLSNGSWNGMIGELINK-RADLAVSAITITPERENVVDFSKRYMDYS--VGILHRKPEEKI 553

  Fly   317 SSFDILFYPYRLQIWMGILGVVALSALIQLIVGR--MLRER--------------MGSRFWLNLE 365
            :.|. ||.|:.|.:|..|...:.:..::..::.|  |||.:              :.|..|: :.
Zfish   554 NIFS-LFAPFDLAVWACIAAAIPVVGVLIFLLTRMQMLRSQNPPGAHHASSMSNSLHSAIWI-VY 616

  Fly   366 LVFVGMPLLECPRSHTARLYCVMLMMYTLIIRTIYQGLLYHLIRTHQLNRWPQTIESLVQKNFTV 430
            ..||.........|...|:......::|||:.:.|...|...:...:::...:|.:.|.::....
Zfish   617 GAFVQQGGDSVVGSVALRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNTIRTFQDLARQMDFA 681

  Fly   431 VLTPIVQEVLD----------EIPSVQHMRFRLLEANSELD-----PLYFLEANHQLRQHVTASA 480
            ..|.....|.|          |..|.....:|.:..|:..|     |   .|...:.::...|..
Zfish   682 YGTVRDSAVYDYFKAKGTNPLEQDSTYAELWRTISKNNGQDFSVSSP---SEGIRKAKKGPYAFL 743

  Fly   481 LDI-FIHFNRLSADKV------HQRGEQGSGAHFEIVPEDIISMQLTMYLAKH-SFLIDQLNEEI 537
            .|: .:.:..|:.|..      :....:|.|          |:||       | |...|.::::|
Zfish   744 WDMAVVEYAALTDDDCTITVSGNSMSSKGYG----------IAMQ-------HGSPYRDLISQKI 791

  Fly   538 MWMRSVGLLSV-----WSRWELSESYLRNEQSFQVLG-TMELYA---IFLMVLVGLIVGLLVFIL 593
            :.::..|.|.|     |.|  .....|.:..:.|..| :::|::   :|.::..||::..||..|
Zfish   792 LELQEKGDLDVLKQKWWPR--TGRCDLNSHSNAQPDGRSLKLHSFAGVFCILAAGLLLACLVAAL 854

  Fly   594 EL 595
            |:
Zfish   855 EM 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	27/133 (20%)
grid1b	XP_009304811.1	PBP1_iGluR_delta_1	25..424	CDD:107387	46/256 (18%)
		ANF_receptor	36..400	CDD:279440	40/232 (17%)
		Periplasmic_Binding_Protein_Type_2	437..809	CDD:304360	77/396 (19%)
		Lig_chan	565..840	CDD:278489	52/297 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591136
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740