DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir7e and Gria1

DIOPT Version :9

Sequence 1:NP_001138176.1 Gene:Ir7e / 7354417 FlyBaseID:FBgn0259189 Length:608 Species:Drosophila melanogaster
Sequence 2:NP_113796.1 Gene:Gria1 / 50592 RGDID:621531 Length:907 Species:Rattus norvegicus


Alignment Length:858 Identity:125/858 - (14%)
Similarity:243/858 - (28%) Gaps:391/858 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 ILSVTPSLVLTLCCRSNHTCNFYNKMMSTLFREWGLAPLQIVNVLRG----------VPWHPVPG 91
            |::::.|..:|.     ..|:.::|.:..:|   |....:.||:|..          .|..||..
  Rat    61 IVNISDSFEMTY-----RFCSQFSKGVYAIF---GFYERRTVNMLTSFCGALHVCFITPSFPVDT 117

  Fly    92 RRHFNVIFTDSFAAFEEIRMEYYSREYNYNEHY----FIFLQARDR---LLQGEMRLIFDYCWR- 148
            ...|.:          ::|.|......:..:||    |:::...||   :||..:....:..|: 
  Rat   118 SNQFVL----------QLRPELQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQV 172

  Fly   149 ------------YRLIHCSIQVQKSN---------------GDILFYSYYPFGEH------GCSD 180
                        ||::...::.:|..               |.|:.......|.|      |..|
  Rat   173 TAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMD 237

  Fly   181 MEPQLINRY-------NGSMLVE-PDLFPRKLRNFFGCPLRCALWDVPPFLTLDEDQEEVLRVNG 237
            ::   :|::       .|..||. .|..|.::..         .|..       .|..:..||:.
  Rat   238 ID---LNKFKESGANVTGFQLVNYTDTIPARIMQ---------QWRT-------SDSRDHTRVDW 283

  Fly   238 GYEGRLLLALAEKMNFTIAVRKVHVNMRDEALEMLRRDEVDLTLGG------------------- 283
                       ::..:|.|:....|.:..||.:.|||..:|::..|                   
  Rat   284 -----------KRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDI 337

  Fly   284 ---IRQTVARGMVATSSHN---------------------------------------------- 299
               ::|....|:......|                                              
  Rat   338 QRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNS 402

  Fly   300 --YHQTREVFGVLASSY---------------------ELSSFDI---LFYPYRLQI-------- 330
              .::|..|..:|...|                     ||:: :|   :.|.|||:|        
  Rat   403 SVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAA-EIAKHVGYSYRLEIVSDGKYGA 466

  Fly   331 -------WMGILGVVALSALIQLIVGR-----------MLRER---------------------- 355
                   |.|::|        :|:.||           ::||.                      
  Rat   467 RDPDTKAWNGMVG--------ELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQK 523

  Fly   356 -----------MGSRFWLNLELVFVGMPLL----------------------------------- 374
                       :....|:.:...::|:.::                                   
  Rat   524 SKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIF 588

  Fly   375 -------------EC---PRSHTARLYCVMLMMYTLIIRTIYQGLLYHLIRTHQLNRWPQTIESL 423
                         .|   |||.:.|:...:...:||||.:.|...|...:          |:|.:
  Rat   589 NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFL----------TVERM 643

  Fly   424 VQKNFTVVLTPIVQEVLDEIPSVQHMRFRLLEANS---------------------ELDPLYFLE 467
            |        :||  |..:::.....:.:..|||.|                     ..:|..|:.
  Rat   644 V--------SPI--ESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVR 698

  Fly   468 ANHQ----LRQ------HVTASALDIFIHFNRLSADKVHQRGEQGSGAHFEIVPEDIISMQLTMY 522
            ...:    :|:      ::..|.::.:|. .|...|.:...|...|..:....|           
  Rat   699 TTEEGMIRVRKSKGKYAYLLESTMNEYIE-QRKPCDTMKVGGNLDSKGYGIATP----------- 751

  Fly   523 LAKHSFLIDQLNEEIMWMRSVGLL-SVWSRW-----ELSESYLRNEQSFQVLGTMELYAIFLMVL 581
              |.|.|.:.:|..::.:...||| .:.::|     |.......::.....|....:..:|.:::
  Rat   752 --KGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILI 814

  Fly   582 VGLIVGLLVFILE 594
            .||.:.:||.::|
  Rat   815 GGLGLAMLVALIE 827

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir7eNP_001138176.1 PBPb 218..>313 CDD:214497 19/164 (12%)
Gria1NP_113796.1 PBP1_iGluR_AMPA_GluR1 26..392 CDD:380613 56/378 (15%)
PBP2_iGluR_AMPA_GluR1 406..787 CDD:270447 61/423 (14%)
Glutamate binding. /evidence=ECO:0000250 492..494 0/1 (0%)