DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7e and GluRIID

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster

Alignment Length:	443	Identity:	91/443 - (20%)
Similarity:	171/443 - (38%)	Gaps:	110/443 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 PFLTLDEDQEEVLRVN--GGYEGRLLLALAEKMNFTIAVR---------KVHVNMRDEALEMLRR 274
            |:.:|.|..:.::..|  .||...|:..||:|:.|....|         ....|.....|:.:..
  Fly   430 PYASLVESIDTLIGNNQFQGYGVDLIKELADKLGFNFTFRDGGNDYGSFNKTTNSTSGMLKEIVE 494

  Fly   275 DEVDLTLGGIRQTVARGMVATSSHNYHQTREVFGVLASSY--------ELSSFDILFYPYRLQIW 331
            ...||.:..:..|..|..|...|..:..    .|: |..|        .|.||   ..|:..::|
  Fly   495 GRADLAITDLTITSEREEVIDFSIPFMN----LGI-AILYVKPQKAPPALFSF---MDPFSSEVW 551

  Fly   332 MGILGVVALS-ALIQLIVGRML-------------RERMGSRFWLNLELVFVGMPLLE-----CP 377
            : .||:..|. :|...|:||:.             .|.:.::|.:|..|.|....||:     .|
  Fly   552 L-YLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEELENQFTINNSLWFTTGALLQQGSEIAP 615

  Fly   378 RSHTARLYCVMLMMYTLIIRTIYQGLLYHLIRTHQLNRWPQTIESLVQKNFTVVLTPI--VQEVL 440
            ::.:.|....:...:|||:.:.|...|...:          |||:        ..:||  |:::.
  Fly   616 KALSTRTISAIWWFFTLIMVSSYTANLAAFL----------TIEN--------PTSPINSVKDLA 662

  Fly   441 DEIPSVQHMRFRL-----LEANSELDPLYFLEANHQLRQHVTASALDIFIHFNRLSADKVHQRGE 500
            |....||:...|.     ..:.|| :|:| ::.|..|..|.     ::.:..|:...|||.
  Fly   663 DNKDDVQYGAKRTGSTRNFFSTSE-EPIY-IKMNEYLNAHP-----EMLMENNQQGVDKVK---- 716

  Fly   501 QGSGAHFEIVPED-------IISMQLT------------MYLAKHSFLIDQLNEEIMWMRSVGLL 546
              ||..:..:.|.       :....||            :.:.|:....|:.|:.::.::..|:|
  Fly   717 --SGTKYAFLMESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVL 779

  Fly   547 S-VWSRW--ELSE---SYLRNEQSFQVLGTMELYAIFLMVLVGLIVGLLVFIL 593
            : :.::|  |:..   |...::.....||...|..|::::::|.|:.:::.||
  Fly   780 ARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISIL 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	22/102 (22%)
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377
		ANF_receptor	46..380	CDD:279440
		PBP2_iGluR_Kainate	417..788	CDD:270432	81/397 (20%)
		Lig_chan	549..819	CDD:278489	60/301 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462847
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740