DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7e and gria4a

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_999971.1	Gene:	gria4a / 407735	ZFINID:	ZDB-GENE-020125-7	Length:	898	Species:	Danio rerio

Alignment Length:	733	Identity:	122/733 - (16%)
Similarity:	234/733 - (31%)	Gaps:	234/733 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DLSGEQMNHINEFVARAVLHVV-HHYILS----VTPSLVLTLCCRSNHT----CNFYNKMMSTLF 67
            ||..|::.:|.|.:.....||. :|||::    ...||...:...:|.|    .:|...|:..|.
Zfish   207 DLEAERLQNILEQIVSVGKHVKGYHYIVANLGFKDISLERFMHGGANVTGFQLVDFSKPMVIKLM 271

  Fly    68 REW------------------------GLAPL---------QIVNVLR-----------GVPWHP 88
            :.|                        |:..:         |.:::.|           ..||:.
Zfish   272 QRWNKLDQREYPGSESPPRYTSSLTYDGVLVMAEAFRNLRRQKIDISRRGNAGDCLANPAAPWNQ 336

  Fly    89 -VPGRRHFNVIFTDSFAAFEEIRMEYYSREYNYNEHYFIFLQARDR------------LLQGEMR 140
             :...|....:.......  .|:.::|.|..||....|.......|            |:|.|:.
Zfish   337 GIDMERTLKQVRIQGLTG--NIQFDHYGRRVNYTMDVFELKSNGPRKIGYWNDLDKLVLVQNELS 399

  Fly   141 LIFDYCWRYRLIHCS-------IQVQKS----NGDILFYSYYPFGEHGCSDMEPQLIN----RYN 190
            :..|.....|.:..:       :.::|:    .|:..|..|       |.|:..::..    :|.
Zfish   400 MGNDSAMENRTVIVTTIMEGPYVMLKKNWEMYEGNEQFEGY-------CVDLASEVAKHIGIKYK 457

  Fly   191 GSMLVEPDLFPRKLRNFFGCPLRCALWDVPPFLTLDEDQEEVLRVNGGYEGRLLLALAEKMNFTI 255
            .|::::.....|                         |.|  .::..|..|.|:...||     |
Zfish   458 ISIVLDGKYGAR-------------------------DPE--TKIWNGMVGELVYGKAE-----I 490

  Fly   256 AVRKVHVNMRDEALEMLRRDEVDLTLGGIRQTVARGMVATSSHNYHQTREVFGVLASSYELSSFD 320
            ||..:       |:.::|.:.:|.:    :..::.|:.............||..|         |
Zfish   491 AVAPL-------AITLVREEVIDFS----KPFMSLGISIMIKKPQKSKPGVFSFL---------D 535

  Fly   321 ILFYPYRLQIWMGIL-GVVALSALIQLIVGRMLRERMGSRF------------------------ 360
            .|.|    :|||.|: ..:.:|.::.|:          |||
Zfish   536 PLAY----EIWMCIVFAYIGVSVVLFLV----------SRFSPYEWHTEEPEEGSDGPPSDQPPN 586

  Fly   361 --------WLNLELVFVGMPLLECPRSHTARLYCVMLMMYTLIIRTIYQGLLYHLIRTHQLNRWP 417
                    |.:|. .|:.......|||.:.|:...:...:||||.:.|...|...:...::....
Zfish   587 EFGIFNSLWFSLG-AFMQQGCDFTPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPI 650

  Fly   418 QTIESLVQKNFTVVLTPIVQEVLDEIPSVQHMRFRLLEANSEL-------DPLYF----LEANHQ 471
            ::.|.|.::      |.|....||...:.:..|...:....::       :|..|    .|...:
Zfish   651 ESAEDLAKQ------TEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFTKTTAEGVAR 709

  Fly   472 LRQ------HVTASALDIFIHFNRLSADKVHQRGEQGSGAHFEIVPEDIISMQLTMYLAKHSFLI 530
            :|:      .:..|.::.:.. .|...|.:...|...|..:....|             |.|.|.
Zfish   710 VRKSKGKYAFLLESTMNEYTE-QRKPCDTMKVGGNLDSKGYGVATP-------------KGSQLG 760

  Fly   531 DQLNEEIMWMRSVGLL-SVWSRWELSESYL------RNEQSFQVLGTMELYAIFLMVLVGLIVGL 588
            ..:|..::.:...|:| .:.::|...:...      ..::|.|.|....:..:|.:::.||.:.:
Zfish   761 TPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKSSQALSLSNVAGVFYILVGGLGLAM 825

  Fly   589 LVFILELVSMRSIYLRKL 606
            ||.::|.........:||
Zfish   826 LVALVEFCYKSRAEAKKL 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	17/94 (18%)
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..393	CDD:107383	31/187 (17%)
		ANF_receptor	34..375	CDD:279440	30/169 (18%)
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	76/475 (16%)
		Lig_chan	540..821	CDD:278489	50/311 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591680
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840