Protein Alignment Ir7e and gria4a

DIOPT Version :10

• Sequence 1: NP_001138176.1
• Gene: Ir7e / 7354417
• FlyBaseID: FBgn0259189
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_999971.1
• Gene: gria4a / 407735
• ZFINID: ZDB-GENE-020125-7
• Length: 898
• Species: Danio rerio
• Alignment Length: 733
• Identity: 122/733 - (16%)
• Similarity: 234/733 - (31%)
• Gaps: 234/733 - (31%)

  Fly    12 DLSGEQMNHINEFVARAVLHVV-HHYILS----VTPSLVLTLCCRSNHT----CNFYNKMMSTLF 67
            ||..|::.:|.|.:.....||. :|||::    ...||...:...:|.|    .:|...|:..|.
Zfish   207 DLEAERLQNILEQIVSVGKHVKGYHYIVANLGFKDISLERFMHGGANVTGFQLVDFSKPMVIKLM 271

  Fly    68 REW------------------------GLAPL---------QIVNVLR-----------GVPWHP 88
            :.|                        |:..:         |.:::.|           ..||:.
Zfish   272 QRWNKLDQREYPGSESPPRYTSSLTYDGVLVMAEAFRNLRRQKIDISRRGNAGDCLANPAAPWNQ 336

  Fly    89 -VPGRRHFNVIFTDSFAAFEEIRMEYYSREYNYNEHYFIFLQARDR------------LLQGEMR 140
             :...|....:.......  .|:.::|.|..||....|.......|            |:|.|:.
Zfish   337 GIDMERTLKQVRIQGLTG--NIQFDHYGRRVNYTMDVFELKSNGPRKIGYWNDLDKLVLVQNELS 399

  Fly   141 LIFDYCWRYRLIHCS-------IQVQKS----NGDILFYSYYPFGEHGCSDMEPQLIN----RYN 190
            :..|.....|.:..:       :.::|:    .|:..|..|       |.|:..::..    :|.
Zfish   400 MGNDSAMENRTVIVTTIMEGPYVMLKKNWEMYEGNEQFEGY-------CVDLASEVAKHIGIKYK 457

  Fly   191 GSMLVEPDLFPRKLRNFFGCPLRCALWDVPPFLTLDEDQEEVLRVNGGYEGRLLLALAEKMNFTI 255
            .|::::.....|                         |.|  .::..|..|.|:...||     |
Zfish   458 ISIVLDGKYGAR-------------------------DPE--TKIWNGMVGELVYGKAE-----I 490

  Fly   256 AVRKVHVNMRDEALEMLRRDEVDLTLGGIRQTVARGMVATSSHNYHQTREVFGVLASSYELSSFD 320
            ||..:       |:.::|.:.:|.:    :..::.|:.............||..|         |
Zfish   491 AVAPL-------AITLVREEVIDFS----KPFMSLGISIMIKKPQKSKPGVFSFL---------D 535

  Fly   321 ILFYPYRLQIWMGIL-GVVALSALIQLIVGRMLRERMGSRF------------------------ 360
            .|.|    :|||.|: ..:.:|.::.|:          |||
Zfish   536 PLAY----EIWMCIVFAYIGVSVVLFLV----------SRFSPYEWHTEEPEEGSDGPPSDQPPN 586

  Fly   361 --------WLNLELVFVGMPLLECPRSHTARLYCVMLMMYTLIIRTIYQGLLYHLIRTHQLNRWP 417
                    |.:|. .|:.......|||.:.|:...:...:||||.:.|...|...:...::....
Zfish   587 EFGIFNSLWFSLG-AFMQQGCDFTPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPI 650

  Fly   418 QTIESLVQKNFTVVLTPIVQEVLDEIPSVQHMRFRLLEANSEL-------DPLYF----LEANHQ 471
            ::.|.|.::      |.|....||...:.:..|...:....::       :|..|    .|...:
Zfish   651 ESAEDLAKQ------TEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFTKTTAEGVAR 709

  Fly   472 LRQ------HVTASALDIFIHFNRLSADKVHQRGEQGSGAHFEIVPEDIISMQLTMYLAKHSFLI 530
            :|:      .:..|.::.:.. .|...|.:...|...|..:....|             |.|.|.
Zfish   710 VRKSKGKYAFLLESTMNEYTE-QRKPCDTMKVGGNLDSKGYGVATP-------------KGSQLG 760

  Fly   531 DQLNEEIMWMRSVGLL-SVWSRWELSESYL------RNEQSFQVLGTMELYAIFLMVLVGLIVGL 588
            ..:|..::.:...|:| .:.::|...:...      ..::|.|.|....:..:|.:::.||.:.:
Zfish   761 TPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKSSQALSLSNVAGVFYILVGGLGLAM 825

  Fly   589 LVFILELVSMRSIYLRKL 606
            ||.::|.........:||
Zfish   826 LVALVEFCYKSRAEAKKL 843

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	Periplasmic_Binding_Protein_Type_2	218..>313	CDD:473866	17/94 (18%)
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..395	CDD:380611	32/189 (17%)
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	76/475 (16%)