DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7e and Ir8a

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster

Alignment Length:	717	Identity:	135/717 - (18%)
Similarity:	247/717 - (34%)	Gaps:	206/717 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 MNHINEFVARAVLH---VVHHYILSVTPSLVL------TLC----------CRSNHTCNFYNKMM 63
            ||.|.|.|.:|.|.   :..|::...|...|.      .||          |||....:.|....
  Fly   195 MNGIFEKVQKADLFQRPLEWHFVFLDTRDRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSG 259

  Fly    64 STLFREWGLAPLQIVNVLRGV-------PWHPVPGRRHFNVIFTD--SFAAFEEIRMEYYSREYN 119
            .|:.|      ..::||||.:       |.:|:       .|:.|  :.|:..|:.......:||
  Fly   260 FTMQR------AMLLNVLRSLINAAQVSPGYPL-------AIYQDCNATASSSEVSDPLEKDDYN 311

  Fly   120 YNE--HYFIFLQARDRLLQGEMRLIFDYCWRYRLIHCSIQVQKSNGDILF-----YSYYPFGEHG 177
            :.:  |:..||                 .:...|.|...|.|.....:.|     ..||......
  Fly   312 WLDMVHWSNFL-----------------AYAPPLPHIQDQFQSPVPGLTFAVNISAGYYSSEHEA 359

  Fly   178 CSDM-------EPQLINRYNGSMLVEPDLFPRKLRNFFGCPLRCALWDVPP--FLTLDEDQEEVL 233
            .:|:       |.:|:|.     .:.|      .|.||    |....:..|  :|..:|...|::
  Fly   360 KTDLAAWSSVGEMRLLNE-----TISP------ARRFF----RIGTAESIPWSYLRREEGTGELI 409

  Fly   234 RVNGG---YEG---RLLLALAEKMNFTIAVRKVHVNMRDEALEM---------LRRDEVDLTLGG 283
            |...|   :||   ..::.|::|:||...:....|....|..|:         |.|.|.|..:..
  Fly   410 RDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAA 474

  Fly   284 IRQTVARGMVATSSHNYHQTREVFGVLASSYELSSFDI----------LF---YPYRLQIWMGIL 335
            ::.             |.:..||...|...||.:...|          ||   ...||::|:.|:
  Fly   475 LKM-------------YSEREEVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVWLSIV 526

  Fly   336 GVVALSALIQLIVGR--------------------MLRERMGSRFWLNLELVFVGMPLLECPRSH 380
            ..:..:|::...:.:                    .|||    .||..| ..|......|.|::.
  Fly   527 AALVGTAIMIWFMDKYSPYSSRNNRQAYPYACREFTLRE----SFWFAL-TSFTPQGGGEAPKAI 586

  Fly   381 TARLYCVMLMMYTLIIRTIYQGLLYHLIRTHQLNRWPQTIESLVQK---NFTVVLTPIVQEVLDE 442
            :.|:......::.:::...:...|...:...::....|::|.|.::   |:|||......:....
  Fly   587 SGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVN 651

  Fly   443 IPSVQHMRFRL---LEANSELDPLYFLEANHQLRQ---HV---------TASALDIFIHFN-RLS 491
            :...:...:|:   |..|:..|...|...::.:::   |:         .|.|.:.|.:.: ..:
  Fly   652 MKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDAHEN 716

  Fly   492 ADK--VHQRGEQGSGAHFEI--------VPEDIISMQLTMYLAKHSFLIDQLNEEIMWMRSVGLL 546
            ||.  :|...|    ..:||        |.|........:.:.:.|.|.|:|:..|:.::.....
  Fly   717 ADYAFIHDSAE----IKYEITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFF 777

  Fly   547 -----SVWSRWELSESYLRNEQ---SFQVLGTMELYAIFLMVLVGLIVGLLVFILELVSMRSIYL 603
                 ..|::..|....|..:|   :.:.||     .:|:..|.||::.::.     :.|..:|.
  Fly   778 EELKAKYWNQSNLPNCPLSEDQEGITLESLG-----GVFIATLFGLVLAMMT-----LGMEVLYY 832

  Fly   604 RK 605
            :|
  Fly   833 KK 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	23/111 (21%)
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	77/428 (18%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	51/311 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810