DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7e and Gria4

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_001106655.1	Gene:	Gria4 / 29629	RGDID:	61863	Length:	902	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	95/546 - (17%)
Similarity:	173/546 - (31%)	Gaps:	153/546 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 GDILFYSYYPFGEHGCSDMEPQL-------------INRYNGSMLVEPDLF------PRKLRNFF 208
            ||.|.....|:|:.  .|||..|             .:.|...:....|:|      |||:..:.
  Rat   329 GDCLANPAAPWGQG--IDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWN 391

  Fly   209 GCPLRCALWDVPPFLTLDED------------------------QEEVLRVNGGYEGRLLLALAE 249
            .......:.|:|   ||..|                        ..|:...|..|||..:...:|
  Rat   392 DMDKLVLIQDMP---TLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASE 453

  Fly   250 -----KMNFTIAV--------RKVHVNMRDEALEMLRRDEVDLTLGGIRQTVARGMVATSSHNYH 301
                 .:.:.||:        |.....:.:..:..|...:.::.:..:..|:.|..|...|..:.
  Rat   454 IAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFM 518

  Fly   302 QTREVFGVLASSYELSSFDILFY--PYRLQIWMGIL-GVVALSALIQLIVGRMLRERMGSRF--- 360
            ...  ..::....:.|...:..:  |...:|||.|: ..:.:|.::.|:          |||
  Rat   519 SLG--ISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLV----------SRFSPY 571

  Fly   361 ----------------------------WLNLELVFVGMPLLECPRSHTARLYCVMLMMYTLIIR 397
                                        |.:|. .|:.......|||.:.|:...:...:||||.
  Rat   572 EWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLG-AFMQQGCDISPRSLSGRIVGGVWWFFTLIII 635

  Fly   398 TIYQGLLYHLIRTHQLNRWPQTIESLVQKNFTVVLTPIVQEVLDEIPSVQHMRFRLLEANSELDP 462
            :.|...|...:...::....::.|.|.::      |.|....||...:.:..| |...|..|...
  Rat   636 SSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLDSGSTKEFFR-RSKIAVYEKMW 693

  Fly   463 LYFLEANHQLRQHVTA------------------SALDIFIHFNRLSADKVHQRGEQGSGAHFEI 509
            .|...|...:....||                  |.::.:|. .|...|.:...|...|..:...
  Rat   694 TYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIE-QRKPCDTMKVGGNLDSKGYGVA 757

  Fly   510 VPEDIISMQLTMYLAKHSFLIDQLNEEIMWMRSVGLL-SVWSRW-----ELSESYLRNEQSFQVL 568
            .|             |.|.|.:.:|..::.:...||| .:.::|     |.......::.....|
  Rat   758 TP-------------KGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSAL 809

  Fly   569 GTMELYAIFLMVLVGLIVGLLVFILE 594
            ....:..:|.:::.||.:.:||.::|
  Rat   810 SLSNVAGVFYILVGGLGLAMLVALIE 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	19/131 (15%)
Gria4	NP_001106655.1	PBP1_iGluR_AMPA_GluR4	28..398	CDD:107383	15/70 (21%)
		ANF_receptor	39..380	CDD:279440	12/52 (23%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	67/414 (16%)
		Lig_chan	546..825	CDD:278489	54/310 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350117
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740