Protein Alignment Ir7e and GRIN2A

DIOPT Version :9

• Sequence 1: NP_001138176.1
• Gene: Ir7e / 7354417
• FlyBaseID: FBgn0259189
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: XP_016878661.1
• Gene: GRIN2A / 2903
• HGNCID: 4585
• Length: 1516
• Species: Homo sapiens
• Alignment Length: 845
• Identity: 138/845 - (16%)
• Similarity: 263/845 - (31%)
• Gaps: 324/845 - (38%)

  Fly     1 MNISALLNSYYD-----------LSGEQMNHI-------NEFVARAVLHVVHHYILSVT-----P 42
            :|:.|||.:..|           :||.:::.:       .|.||:.:..:..|..:.:.     .
Human   119 VNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGA 183

  Fly    43 SLVLTLCCRSNHTCNFYNKMMSTLFREWGLAPLQ----IVNVLRGVPWHP-------VPGRRHF- 95
            |:::.            :|..::.|.::|.:..|    ::.:::...||.       .||.|.|
Human   184 SMIMA------------DKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFI 236

  Fly    96 -----------------NVIFTDSFAAFEEIRME-------------YYSREYNYNEHYFIFLQA 130
                             |||..|:  :||:.:.:             |.|::    |...|..:|
Human   237 SFVKTTVDNSFVGWDMQNVITLDT--SFEDAKTQVQLKKIHSSVILLYCSKD----EAVLILSEA 295

  Fly   131 RD-------------RLLQGEMRLI------------FDYCWRYRL---IHCSIQVQKSNGDILF 167
            |.             .|:.|...||            :| .|.|.|   :...|.:..:....:.
Human   296 RSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYD-DWDYSLEARVRDGIGILTTAASSML 359

  Fly   168 --YSYYPFGEHGC-SDME----------PQLIN-RYNGSML--------VEPDL----------- 199
              :||.|..:..| ..||          |.::| .::|..|        |.|.|
Human   360 EKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREW 424

  Fly   200 -----------------FPRKLRNFFGCP-----LRCALWDVPPFLTLDE-DQEEVLRVNGGYEG 241
                             :|| .::|..|.     |.....:..||:.::: |......|......
Human   425 EKVGKWENHTLSLRHAVWPR-YKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPC 488

  Fly   242 RLLLALAEKMNFTIAVRKVHVNMRDEALEMLRRD---EVDLTL---------------GGIRQTV 288
            |..:.:....|..:.|:|.......:.|:.|.|.   ..||.|               |.|.:.|
Human   489 RKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVV 553

  Fly   289 -ARGMVATSSHNYHQTREVFGVLASSYELSSFDILFY----------------------PYRLQI 330
             .|.::|..|...::.|.         |:..|.:.|.                      |:...:
Human   554 YQRAVMAVGSLTINEERS---------EVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASV 609

  Fly   331 WMGILGVVALSALIQLIV---------GRMLRE---------RMGSRFWLNLELVFVGMPLLECP 377
            |:.:..::.:.:.|.:.|         .|.|.:         .:|...||...|||.....::.|
Human   610 WVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNP 674

  Fly   378 RSHTARLYCVMLMMYTLIIRTIYQGLLYHLIRTHQLNRWPQTIESLVQKNFTVVLTPIVQEVLDE 442
            :..|:::...:...:.:|....|...|...:                          |.:|.:|:
Human   675 KGTTSKIMVSVWAFFAVIFLASYTANLAAFM--------------------------IQEEFVDQ 713

  Fly   443 IPSVQHMRFRLLEANSELDPLYF-----------LEANH-QLRQHVT---------------ASA 480
            :..:...:|:  ..:....|..|           :..|: .:.|::|               ...
Human   714 VTGLSDKKFQ--RPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGK 776

  Fly   481 LDIFIH----FN-RLSADKVHQRGEQGSGAHFEIVPEDIISMQLTMY-----LAKHSFLIDQLNE 535
            ||.||:    .| :...|:..:....|||..|......|...:.:.:     ||...|:.|...|
Human   777 LDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEME 841

  Fly   536 EI--MWMRSVGLLSVWSRWELSESYLRNEQSFQVLGTM----ELYAIFLMVLVGLIVGLLVFILE 594
            |:  :|:..:               ..||:: :|:.:.    .:..:|.|:...:.:.|:.||.|
Human   842 ELETLWLTGI---------------CHNEKN-EVMSSQLDIDNMAGVFYMLAAAMALSLITFIWE 890

  Fly   595  594
            Human   891  890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	21/114 (18%)
GRIN2A	XP_016878661.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156043
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740