DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7e and GRIK5

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens

Alignment Length:	689	Identity:	116/689 - (16%)
Similarity:	218/689 - (31%)	Gaps:	243/689 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LNSYYDLSGEQMNHINEFVARAVLHVVHHYILSVTPSLVLTLCCRSNHTCNFYNKMMSTLFREWG 71
            ||..:..:.|...::...::.|::....|.::|....|               |:.     :|.|
Human   284 LNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVREL---------------NRS-----QEIG 328

  Fly    72 LAPL------------QIVNVLRGVPWHPVPGRRHFNVIFTDSFAAFEEIRMEYYSREYNYNEHY 124
            :.||            .::|.||.|.:..:.||..||                ...:..||.
Human   329 VKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFN----------------SKGQRTNYT--- 374

  Fly   125 FIFLQARDRLLQGEMRLIFDYCWRYRLIHCSIQVQKSNGDILFYSYYPFGEHGCSDMEPQLINRY 189
               |:..::..||               |..|.|..||..:..         ..:.::..|....
Human   375 ---LRILEKSRQG---------------HREIGVWYSNRTLAM---------NATTLDINLSQTL 412

  Fly   190 NGSMLVEPDLF--PRKLRNFFGCPLRCALWDVPPFLTLDEDQEEVLRVNGGYEG---RLLLALAE 249
            ....||...:.  |..:|.             |.|        :.|..|..:||   .:|..|||
Human   413 ANKTLVVTTILENPYVMRR-------------PNF--------QALSGNERFEGFCVDMLRELAE 456

  Fly   250 KMNFTIAVRKVHVNMRDEAL---------------EMLRRDEVDLTLGGIRQTVARGMVATSS-- 297
            .:.|...:|.|     ::.|               |::.|.:.||.:.....|..|..|...|
Human   457 LLRFRYRLRLV-----EDGLYGAPEPNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKP 516

  Fly   298 ---------HNYHQTREVFGVLASSYELSSFDILFYPYRLQIWM-GILGVVALSALIQLIVGRM- 351
                     :..|..|:      ..| .|..|    |:...:|: .:|..:|:|.:: .:..|:
Human   517 FMTLGISILYRVHMGRK------PGY-FSFLD----PFSPAVWLFMLLAYLAVSCVL-FLAARLS 569

  Fly   352 ----------LRER---------MGSRFWLNL-ELVFVGMPLLECPRSHTARLYCVMLMMYTLII 396
                      ||.|         :|:..|..: ..:..|..::  ||:.:.|....:...:||||
Human   570 PYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIM--PRALSTRCVSGVWWAFTLII 632

  Fly   397 RTIYQGLLYHLIRTHQLNRWPQTIESLVQKNFTVVLTPIVQEVLDEIPSVQHMRFRLLEANSELD 461
            .:.|...|...:...::.                  .|:  |..|::....::.:..:.|.|.:
Human   633 ISSYTANLAAFLTVQRME------------------VPV--ESADDLADQTNIEYGTIHAGSTM- 676

  Fly   462 PLYFLEANHQLRQ----HVTASALDIFI-------------------------HFNRLSADKVHQ 497
             .:|..:.:|..|    ::.:....:|:                         :..||:.:....
Human   677 -TFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQI 740

  Fly   498 RG---EQGSGAHFEIVPEDIISMQLTMYLAKHSFLIDQLNEEIMWMRSVGLLSVWSR--WELSES 557
            .|   .:|.|          |.|.|      .|...|::...|:.::....|.:..|  ||....
Human   741 GGLLDTKGYG----------IGMPL------GSPFRDEITLAILQLQENNRLEILKRKWWEGGRC 789

  Fly   558 YLRNEQSFQVLGTMELYAIFLMVLVGLIVGLLVFILELV 596
            ....:...:.||...:..||::::.|||:.:.|.::|.:
Human   790 PKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFI 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	24/123 (20%)
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	30/171 (18%)
		ANF_receptor	42..379	CDD:279440	23/136 (17%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	74/448 (17%)
		Lig_chan	546..816	CDD:278489	48/310 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156221
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840