DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7e and GRIK3

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_000822.2	Gene:	GRIK3 / 2899	HGNCID:	4581	Length:	919	Species:	Homo sapiens

Alignment Length:	655	Identity:	129/655 - (19%)
Similarity:	218/655 - (33%)	Gaps:	220/655 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 AVLHVVHHYILSV----TPSL-VLTLCCRSNHTCNFYNKMMSTLFR-EW-GLAPLQIVNVLRGV- 84
            |:|:...| |:||    .|.: |.:|.|..:....|..:.|:.:.. :| ||....:.|...|:
Human   324 ALLYDAVH-IVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLR 387

  Fly    85 -------------------PWHPVPG--------RRHFNVIFTDSFAAFEEIRMEYYSREYNYNE 122
                               .|.|..|        .|..||  |||......|.....       |
Human   388 TDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNV--TDSLTNRSLIVTTVL-------E 443

  Fly   123 HYFIFLQARDRLLQGEMRLIFD-YCWRYRLIHCSIQVQKSNGDILFYSY----YPFGEHGCSDME 182
            ..|:..:..||.|.|..|  |: ||         |.:.|....||.:||    ...|::|..|.:
Human   444 EPFVMFRKSDRTLYGNDR--FEGYC---------IDLLKELAHILGFSYEIRLVEDGKYGAQDDK 497

  Fly   183 PQLINRYNGSMLVEPDLFPRKLRNFFGCPLRCALWDVPPFLTLDEDQEEVLRVNGGYEGRLLLAL 247
            .|    :|| |:.|                           .:|...:              ||:
Human   498 GQ----WNG-MVKE---------------------------LIDHKAD--------------LAV 516

  Fly   248 AEKMNFTIAVRKVHVNMRDEALEMLRRDEVDLTLGGIRQTVARGMVATSSHNYHQTR-EVFGVLA 311
            |.   .||    .||  |::|::.   .:..:|||          |:......:.|. .||..|
Human   517 AP---LTI----THV--REKAIDF---SKPFMTLG----------VSILYRKPNGTNPSVFSFL- 558

  Fly   312 SSYELSSFDILFYPYRLQIWMGI-LGVVALSALIQLIV---------------GRMLRER---MG 357
                        .|....|||.: |..:.:|.::.:|.               |..:.|.   :.
Human   559 ------------NPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLL 611

  Fly   358 SRFWLNL-ELVFVGMPLLECPRSHTARLYCVMLMMYTLIIRTIYQGLLYHLIRTHQLNRWPQTIE 421
            :.||..: .|:..|..|:  |::.:.|:...:...:||||.:.|...|...:...::.....:.:
Human   612 NSFWFGMGSLMQQGSELM--PKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSAD 674

  Fly   422 SLVQKNFTVVLTPIVQEVLDEIPSVQHMR------FRLLEANSELDPLYFLEANHQ-LRQHVTAS 479
            .|.::      |.|....:.:..::...:      |..:.|.....|...::.|.: :::.:||
Human   675 DLAKQ------TKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTA- 732

  Fly   480 ALDIFIHFNRLSADKVHQRG-----------EQGSGAHFEIVPEDIISMQLTMYLAKHSFLIDQL 533
              |..:.....:.:.|.||.           .:|.|         |.:...:.|..|.:..|.||
Human   733 --DYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYG---------IGTPMGSPYRDKITIAILQL 786

  Fly   534 NEE----IM---WMRSVGLLSVWSRWELSESYLRNEQSFQVLGTMELYAIFLMVLVGLIVGLLVF 591
            .||    ||   |.|..|...            ...:....||..::..||:::..||::.:||.
Human   787 QEEDKLHIMKEKWWRGSGCPE------------EENKEASALGIQKIGGIFIVLAAGLVLSVLVA 839

  Fly   592 ILELV 596
            :.|.|
Human   840 VGEFV 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	18/95 (19%)
GRIK3	NP_000822.2	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	20/93 (22%)
		ANF_receptor	55..398	CDD:279440	17/74 (23%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	91/486 (19%)
		Lig_chan	564..832	CDD:278489	53/299 (18%)
		Glutamate binding. /evidence=ECO:0000250	690..692		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156186
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740