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Protein Alignment Ir7e and GRIK2

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	721	Identity:	129/721 - (17%)
Similarity:	230/721 - (31%)	Gaps:	220/721 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YDLSGEQMNHI-NEFVARAVLHVVHHYI--------LSVTPSLVLTLCCRSNHTCNFYNKMMSTL 66
            :|.|.|....| .:.:|..::...:|||        |.|.|.....:........|..|..:|::
Human   228 FDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSI 292

  Fly    67 FREWGLAPLQIVNVLRGVPWHPVPGRRHFNVIFTDSFAAFEEIRMEYYSREYNYNEHYFIFLQAR 131
            ..:|.:..||       .|..|..|       ..|.|...:...|      |:......:.:|..
Human   293 IEKWSMERLQ-------APPKPDSG-------LLDGFMTTDAALM------YDAVHVVSVAVQQF 337

  Fly   132 DRLLQGEMRLIFDYCWRYRLIHCSIQVQKSN-----GDILFYSYYPFGEHGCSDMEPQLINRYNG 191
            .::....::......||:.....|: :::::     |.|.|                   |:.||
Human   338 PQMTVSSLQCNRHKPWRFGTRFMSL-IKEAHWEGLTGRITF-------------------NKTNG 382

  Fly   192 SMLVEPDLFPRKLRNFFGCPL---------RCALWDVPPFLTLDEDQ------------------ 229
                        ||..|...:         :...||....|.:.|.|
Human   383 ------------LRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIV 435

  Fly   230 --------------EEVLRVNGGYEG---RLLLALAEKMNFTIAVRKVH---VNMRDEA------ 268
                          ::.|..|..:||   .||..|:..:.||..:|.|.   ...:|:|
Human   436 TTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNG 500

  Fly   269 -LEMLRRDEVDLTLGGIRQTVARGMVATSSHNYHQTREVFGVLASS--YELSS------FDILFY 324
             :..|...:.||.:..:..|..|..|...|       :.|..|..|  |...:      |..| .
Human   501 MVRELIDHKADLAVAPLAITYVREKVIDFS-------KPFMTLGISILYRKPNGTNPGVFSFL-N 557

  Fly   325 PYRLQIWMGILGVVALSALIQLIVGRML-------------------RERMGSRFWLNL-ELVFV 369
            |....|||.||......:.:..::.|..                   ...:.:.||..: .|:..
Human   558 PLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQ 622

  Fly   370 GMPLLECPRSHTARLYCVMLMMYTLIIRTIYQGLLYHLIRTHQLNRWPQTIESLVQKNFTVVLTP 434
            |..|:  |::.:.|:...:...:||||.:.|...|...:...::.....:.:.|.::      |.
Human   623 GSELM--PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ------TK 679

  Fly   435 IVQEVLDEIPSVQHMRFRLLEANSELDPLY----------FLEANHQLRQHVTASALDIFIHFNR 489
            |....:::..:   |.|......|..|.::          .:::|.:..|.|..|  |.......
Human   680 IEYGAVEDGAT---MTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTS--DYAFLMES 739

  Fly   490 LSADKVHQRG-----------EQGSGAHFEIVPEDIISMQLTMYLAKHSFLIDQLNEEIMWMRSV 543
            .:.:.|.||.           .:|.|         :.:...:.|..|.:..|.||.||
Human   740 TTIEFVTQRNCNLTQIGGLIDSKGYG---------VGTPMGSPYRDKITIAILQLQEE------- 788

  Fly   544 GLLSVWSRWELSESYLR-----NEQSFQ--VLGTMELYAIFLMVLVGLIVGLLVFILELV--SMR 599
            |.|.:     :.|.:.|     .|:|.:  .||...:..||:::..||::.:.|.:.|.:  |.:
Human   789 GKLHM-----MKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKK 848

  Fly   600 SIYLRK 605
            :..|.|
Human   849 NAQLEK 854

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.