DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7e and GRID2

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	XP_011530195.2	Gene:	GRID2 / 2895	HGNCID:	4576	Length:	1035	Species:	Homo sapiens

Alignment Length:	795	Identity:	132/795 - (16%)
Similarity:	228/795 - (28%)	Gaps:	331/795 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NISALLNSYYD-LSGEQMNHINEFVARAVL------------HVVH--------HYIL------- 38
            ||:.::.:.:| :..|::|...:.:.||:|            .||.        |:|:
Human   215 NINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIINEEIND 279

  Fly    39 ---------SV-----------TPSLVLTLCCRSNH-----TCN-----FYNKMMSTLF------ 67
                     |:           .|..:...|.|.||     .|:     ..|..:|.|:
Human   280 VDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVL 344

  Fly    68 ------------REW-GLAPLQIVNVLRGVPWHPVPGRRHFNVIFTDSFAAFEEIRMEYYSREYN 119
                        |:| .:|.|..:. ....||.  .||.....|.....:.... .:|:.....|
Human   345 LLANAFHKKLEDRKWHSMASLSCIR-KNSKPWQ--GGRSMLETIKKGGVSGLTG-ELEFGENGGN 405

  Fly   120 YNEHYFIF-----------LQARDRLL-QGEMRLIFDY--CWRYRLIHCSIQVQKSNGDILFYSY 170
            .|.|:.|.           ::..:|:. ||....|:..  ||.        .|...||.:
Human   406 PNVHFEILGTNYGEELGRGVRKNERIRPQGSTGKIWPQLGCWN--------PVTGLNGSL----- 457

  Fly   171 YPFGEHGCSDMEPQLINRYNG------SMLVEPDLF--------PRKLRNF-------------- 207
                      .:.:|.|...|      ::|.||.:.        |:|.:.|
Human   458 ----------TDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGF 512

  Fly   208 -----------FGCPLRCALW------------DVP-PFLTLDEDQEEVLRVNGGYEGRLLLALA 248
                       :|.|.....|            |:. ..||:..|:|.|:.....|
Human   513 NYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRY--------- 568

  Fly   249 EKMNFTIAVRKVHVNMRDEALEMLRRDEVDLTLGGIRQTVARGMVATSSHNYHQTREVFGVLASS 313
              |::::.|             :|||.|                         :|.::|..||
Human   569 --MDYSVGV-------------LLRRAE-------------------------KTVDMFACLA-- 591

  Fly   314 YELSSFDILFYPYRLQIWMGILGVVALSALIQLIVGRMLRERMGSRFWLNLELVFVGMPLLECPR 378
                       |:.|.:|..|.|.|.|..|:..::.           |||       .|.|:...
Human   592 -----------PFDLSLWACIAGTVLLVGLLVYLLN-----------WLN-------PPRLQMGS 627

  Fly   379 SHTARLYCVMLMMYTLIIRTIYQG--LLYHLIRTH-QLNRW---PQTIESLVQKNFTVVLT---- 433
            ..:..||..|..:|...::   ||  :.|..:.|. .:..|   ...:.|....|....||
Human   628 MTSTTLYNSMWFVYGSFVQ---QGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRI 689

  Fly   434 -PIVQEVLD-----EIP--------SVQHMRFRLLEANSELDPLY-----FLEANHQLRQHVTAS 479
             ..:|.:.|     |||        ..:|:|.:.|.. .|.|.:|     .:..::....:|..|
Human   690 ESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNP-FERDSMYSQMWRMINRSNGSENNVLES 753

  Fly   480 ALDI----------------------------FIHFNRLSADKVHQRGEQGSGAHFEIVPEDIIS 516
            ...|                            |.......||:.:....|....:.::..:.|:.
Human   754 QAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILE 818

  Fly   517 MQLT--MYLAKHSFLIDQLNEEIMWMRSVGLLSVWSRWELSESYLRNEQSFQVLGTMELYAIFLM 579
            :|..  |.:.||.           |....|...::|.       :..:|....|.......:|.:
Human   819 LQQNGDMDILKHK-----------WWPKNGQCDLYSS-------VDTKQKGGALDIKSFAGVFCI 865

  Fly   580 VLVGLIVGLLVFILE 594
            :..|:::...:.:||
Human   866 LAAGIVLSCFIAMLE 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	17/95 (18%)
GRID2	XP_011530195.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156078
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740