back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7e and GRIA4

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_000820.4	Gene:	GRIA4 / 2893	HGNCID:	4574	Length:	902	Species:	Homo sapiens

Alignment Length:	546	Identity:	95/546 - (17%)
Similarity:	172/546 - (31%)	Gaps:	153/546 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 GDILFYSYYPFGEHGCSDMEPQL-------------INRYNGSMLVEPDLF------PRKLRNFF 208
            ||.|.....|:|:.  .|||..|             .:.|...:....|:|      |||:..:.
Human   329 GDCLANPAAPWGQG--IDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWN 391

  Fly   209 GCPLRCALWDVPPFLTLDED------------------------QEEVLRVNGGYEGRLLLALAE 249
            .......:.|||   ||..|                        ..|:...|..|||..:...:|
Human   392 DMDKLVLIQDVP---TLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASE 453

  Fly   250 -----KMNFTIAV--------RKVHVNMRDEALEMLRRDEVDLTLGGIRQTVARGMVATSSHNYH 301
                 .:.:.||:        |.....:.:..:..|...:.::.:..:..|:.|..|...|..:.
Human   454 IAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFM 518

  Fly   302 QTREVFGVLASSYELSSFDILFY--PYRLQIWMGIL-GVVALSALIQLIVGRMLRERMGSRF--- 360
            ...  ..::....:.|...:..:  |...:|||.|: ..:.:|.::.|:          |||
Human   519 SLG--ISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLV----------SRFSPY 571

  Fly   361 ----------------------------WLNLELVFVGMPLLECPRSHTARLYCVMLMMYTLIIR 397
                                        |.:|. .|:.......|||.:.|:...:...:||||.
Human   572 EWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLG-AFMQQGCDISPRSLSGRIVGGVWWFFTLIII 635

  Fly   398 TIYQGLLYHLIRTHQLNRWPQTIESLVQKNFTVVLTPIVQEVLDEIPSVQHMRFRLLEANSELDP 462
            :.|...|...:...::....::.|.|.::      |.|....||...:.:..| |...|..|...
Human   636 SSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLDSGSTKEFFR-RSKIAVYEKMW 693

  Fly   463 LYFLEANHQLRQHVTA------------------SALDIFIHFNRLSADKVHQRGEQGSGAHFEI 509
            .|...|...:....||                  |.::.:|. .|...|.:...|...|..:...
Human   694 TYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIE-QRKPCDTMKVGGNLDSKGYGVA 757

  Fly   510 VPEDIISMQLTMYLAKHSFLIDQLNEEIMWMRSVGLL-SVWSRW-----ELSESYLRNEQSFQVL 568
            .|             |.|.|...:|..::.:...|:| .:.::|     |.......::.....|
Human   758 TP-------------KGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKTSAL 809

  Fly   569 GTMELYAIFLMVLVGLIVGLLVFILE 594
            ....:..:|.:::.||.:.:||.::|
Human   810 SLSNVAGVFYILVGGLGLAMLVALIE 835

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.