DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7e and Grin2c

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_036707.3	Gene:	Grin2c / 24411	RGDID:	2739	Length:	1250	Species:	Rattus norvegicus

Alignment Length:	416	Identity:	83/416 - (19%)
Similarity:	142/416 - (34%)	Gaps:	120/416 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 RVNGGYEGRLLLALAEKMNFTIAVRKVHVNMRDEALEML-----RRDEVDLTLGGIRQTVARGMV 293
            ||.|.:.|              .:.:|:....|.|:..|     |.:.:|.::..: :|....||
  Rat   499 RVRGVWNG--------------MIGEVYYKRADMAIGSLTINEERSEIIDFSVPFV-ETGISVMV 548

  Fly   294 ATSSHNYHQTREVFGVLASSYELSSFDILFYPYRLQIWMGI----LGVVALSALI---------- 344
            :.|:          |.::.|..|.       ||...:|:.:    |.|||::..:
  Rat   549 SRSN----------GTVSPSAFLE-------PYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYN 596

  Fly   345 -QLIVGRM---LRERMGSRFWLNLELVFVGMPLLECPRSHTARLYCVMLMMYTLIIRTIYQGLLY 405
             .|..|:.   ....:|...||...|||.....:|.||..|:::..::...:.:|....|...|.
  Rat   597 QNLTKGKKPGGPSFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLA 661

  Fly   406 HLIRTHQLNRWPQTIESLVQKNFTVVLTPIVQEVLDEIPSVQHMRF---------RLLEANSELD 461
            ..:...|   :..|:..|..|.|        |...|:.|.   .||         |.:.:|....
  Rat   662 AFMIQEQ---YIDTVSGLSDKKF--------QRPQDQYPP---FRFGTVPNGSTERNIRSNYRDM 712

  Fly   462 PLYFLEANHQLRQHVTAS----ALDIFIH----FNRLSA-DKVHQRGEQGSGAHFEIVPEDIISM 517
            ..:.::.|.:..:....|    .||.||:    .|.::. |:..:....|||..|...... |:|
  Rat   713 HTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYG-IAM 776

  Fly   518 QLTMYLAKHSFLIDQLNEEIMWMRSVGLL--------------SVWSRWELSESYLRNEQSFQVL 568
            |                ::..|.|::.|.              :||........  :||.....|
  Rat   777 Q----------------KDSHWKRAIDLALLQLLGDGETQKLETVWLSGICQNE--KNEVMSSKL 823

  Fly   569 GTMELYAIFLMVLVGLIVGLLVFILE 594
            ....:..:|.|:||.:.:.||||..|
  Rat   824 DIDNMAGVFYMLLVAMGLALLVFAWE 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	15/83 (18%)
Grin2c	NP_036707.3	PBP1_iGluR_NMDA_NR2	41..397	CDD:380601
		PBP2_iGluR_NMDA_Nr2	413..813	CDD:270436	71/376 (19%)
		NMDAR2_C	850..>925	CDD:402274	83/416 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350138
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740