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Protein Alignment Ir7e and Grin2a

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_036705.3	Gene:	Grin2a / 24409	RGDID:	2737	Length:	1464	Species:	Rattus norvegicus

Alignment Length:	756	Identity:	123/756 - (16%)
Similarity:	233/756 - (30%)	Gaps:	275/756 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 NKMMSTLFREWGLAPLQ----IVNVLRGVPWHP-------VPGRRHF------------------ 95
            :|..::.|.::|.:..|    ::.:::...||.       .||.|.|
  Rat   137 DKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYRDFISFIKTTVDNSFVGWDMQ 201

  Fly    96 NVIFTDSFAAFEEIRME-------------YYSREYNYNEHYFIFLQARD-------------RL 134
            |||..|:  :||:.:.:             |.|::    |...|..:||.             .|
  Rat   202 NVITLDT--SFEDAKTQVQLKKIHSSVILLYCSKD----EAVLILSEARSLGLTGYDFFWIVPSL 260

  Fly   135 LQGEMRLI---------------FDYCWRYRL--------IHCSIQVQKSNGDILFYSYYPFGEH 176
            :.|...||               :||....|:        ...|..::|       :||.|..:.
  Rat   261 VSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGLGILTTAASSMLEK-------FSYIPEAKA 318

  Fly   177 GC-----------------------------------------------SDMEPQLINRY-NGSM 193
            .|                                               .|.|.:.:.:: |.::
  Rat   319 SCYGQAEKPETPLHTLHQFMVNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENQTL 383

  Fly   194 LVEPDLFPRKLRNFFGCP-----LRCALWDVPPFLTLDE-DQEEVLRVNGGYEGRLLLALAEKMN 252
            .:...::|| .::|..|.     |.....:..||:.::: |......|......|..:.:....|
  Rat   384 SLRHAVWPR-YKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTN 447

  Fly   253 FTIAVRKVHVNMRDEALEMLRRD---EVDLTL---------------GGIRQTV-ARGMVATSSH 298
            ..:.|:|.......:.|:.|.|.   ..||.|               |.|.:.| .|.::|..|.
  Rat   448 EGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSL 512

  Fly   299 NYHQTREVFGVLASSYELSSFDILFY----------------------PYRLQIWMGILGVVALS 341
            ..::.|.         |:..|.:.|.                      |:...:|:.:..::.:.
  Rat   513 TINEERS---------EVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIV 568

  Fly   342 ALIQLIV---------GRMLRE---------RMGSRFWLNLELVFVGMPLLECPRSHTARLYCVM 388
            :.|.:.|         .|.|.:         .:|...||...|||.....::.|:..|:::...:
  Rat   569 SAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSV 633

  Fly   389 LMMYTLIIRTIY-QGLLYHLIRTHQLNRWPQTIESLVQKNF-------------TVVLTPIVQEV 439
            ...:.:|....| ..|...:|:...:::    :..|..|.|             ||......:.:
  Rat   634 WAFFAVIFLASYTANLAAFMIQEEFVDQ----VTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNI 694

  Fly   440 LDEIPSVQHMRFRLLEANSELDPLYFLEANHQLRQHVTASALDIFIH----FN-RLSADKVHQRG 499
            .:..|.:.....|..:...| |.|..|:          ...||.||:    .| :...|:..:..
  Rat   695 RNNYPYMHQYMTRFNQRGVE-DALVSLK----------TGKLDAFIYDAAVLNYKAGRDEGCKLV 748

  Fly   500 EQGSGAHFEIVPEDIISMQLTMY-----LAKHSFLIDQLNEEI--MWMRSVGLLSVWSRWELSES 557
            ..|||..|......|...:.:.:     ||...|:.|...||:  :|:..:
  Rat   749 TIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGI-------------- 799

  Fly   558 YLRNEQSFQVLGTM----ELYAIFLMVLVGLIVGLLVFILE 594
             ..||:: :|:.:.    .:..:|.|:...:.:.|:.||.|
  Rat   800 -CHNEKN-EVMSSQLDIDNMAGVFYMLAAAMALSLITFIWE 838

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.