DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7e and Grin3a

DIOPT Version :9

Sequence 1:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_001263284.1	Gene:	Grin3a / 242443	MGIID:	1933206	Length:	1135	Species:	Mus musculus

Alignment Length:	781	Identity:	147/781 - (18%)
Similarity:	252/781 - (32%)	Gaps:	290/781 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNISALLNSYYDLSGEQMNHINEFVARAVLHVVHHYILSVTPSLVLTLCCRSNHTCNFYNKMMST 65
            :||:|.|:|..||             .:.|.|....|.:.||::|:..|...:....|   .|||
Mouse   295 INITANLSSTKDL-------------LSFLQVQLENIRNSTPTMVMFGCDMGSIRQIF---EMST 343

  Fly    66 LF------REWGLAPLQIVNVLR--GVPWHPVPGRRHFNVIFTDSFAAFEEIRMEYYSREYNYNE 122
            .|      ..|.|...|.|..||  |:|...:...:....:|            |||.::
Mouse   344 QFGLSPPDLHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVF------------EYYVQD----- 391

  Fly   123 HYFIFLQAR----DRLLQGEMRLI----------------FDYCWR------YRLIHCSIQVQ-- 159
              .:.|.||    ..::|.|:.|:                ..|..|      :|.:..||:|:
Mouse   392 --AMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGS 454

  Fly   160 -----KSNGDILFYSYYPFGEHGCSDMEPQLINRYNGSMLVEPDLFP---RKLRNFFGCP----L 212
                 ::|..|....|.|.|:    .|..:|.:...|.::::..::|   ::.:..|..|    |
Mouse   455 TIVSSENNFFIWNLQYDPMGK----PMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFHHPNKLHL 515

  Fly   213 RCALWDVPPFLTLDEDQEEVLRVNG-------------------------------------GYE 240
            |.......||:...|..:|.|...|                                     ||.
Mouse   516 RVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGYC 580

  Fly   241 GRLLLALAEKMNFTI-----------AVRKVH-VNMRDEALEMLRRDEVDLTLGGIRQTVARGMV 293
            ..||..|||.|||..           |.:..| ..:..:.|.    ...::.:.......||..|
Mouse   581 IDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLS----GTANMAVTSFSINTARSQV 641

  Fly   294 ATSSHNYHQTREVFGVLASSYELSS-FDILFYPYRLQIWMGILGVV------------------- 338
            ...:..:..|.  .|:|..:.:.:: .....:|....:|:||...:
Mouse   642 IDFTSPFFSTS--LGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMT 704

  Fly   339 --------------ALSALIQLIVGRMLRER----MGSRFWLNLELVFVGMPLLECPRSHTARLY 385
                          ||:....|:.||....:    ...||.:||..:|    .:.|..::||.|.
Mouse   705 PKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIF----CMFCLSTYTANLA 765

  Fly   386 CVMLMMYTLIIRTIY---------------QGLLYHLIRTHQLNRWPQTIESLVQKNFTVVLTPI 435
            .||      :...||               ||..:..:|       ..:.|..|:::|     |.
Mouse   766 AVM------VGEKIYEELSGIHDPKLHHPSQGFRFGTVR-------ESSAEDYVRQSF-----PE 812

  Fly   436 VQEVLD--EIPS----VQHMRFRLLEANSELDPLYFLEANHQLRQHVTASALDIFIHFNRL---- 490
            :.|.:.  .:|:    ||:::         .||                ..||.||....|
Mouse   813 MHEYMRRYNVPATPDGVQYLK---------NDP----------------EKLDAFIMDKALLDYE 852

  Fly   491 ---SAD-KVHQRGE----QGSGAHFEIVPEDIISMQLTMYLAKHSFLIDQLNEEIMWMRSVGLLS 547
               .|| |:...|:    :|.|                :.|..:|.|...::|.|...:|.|.:.
Mouse   853 VSIDADCKLLTVGKPFAIEGYG----------------IGLPPNSPLTSNISELISQYKSHGFMD 901

  Fly   548 VWSRWELSESYLR----NEQSFQVLGTMEL-----YAIFLMVLVGLIVGLLVFILELVSMRSIYL 603
            |     |.:.:.:    .::||.|..|:::     ..:|:::.:|..:.:|..|.|.:..|.:..
Mouse   902 V-----LHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLP 961

  Fly   604 R 604
            |
Mouse   962 R 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	25/143 (17%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	51/240 (21%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	82/469 (17%)
		Lig_chan	676..942	CDD:278489	59/333 (18%)
		PPP2CB binding site. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	951..987		3/12 (25%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846522
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740